gemfibrozil   Click here for help

GtoPdb Ligand ID: 3439

Synonyms: CI-719 | Gen-Fibro® | Jezil®
Approved drug PDB Ligand
gemfibrozil is an approved drug (FDA (1993))
Compound class: Synthetic organic
Comment: Gemfibrozil is a fibric acid antilipemic agent, pharmacologically similar to clofibrate.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 46.53
Molecular weight 250.16
XLogP 3.35
No. Lipinski's rules broken 0
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Canonical SMILES Cc1ccc(c(c1)OCCCC(C(=O)O)(C)C)C
Isomeric SMILES Cc1ccc(c(c1)OCCCC(C(=O)O)(C)C)C
InChI InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
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Summary of Clinical Use Click here for help
Gemfibrozil is used to treat adults with high serum triglyceride levels.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Gemfibrozil is a peroxisome proliferator-activated receptor alpha (PPARα) agonist. Activation of PPARα causes increased transcription/translation of lipoprotein lipase which in turn leads to increased triglyceride clearance.