- Guide to PHARMACOLOGY
Synonyms: ABDP | BPH 1 | Fosamax® | MK-217
alendronate is an approved drug (FDA (1995), EMA (2005))
Compound class: Synthetic organic
Comment: Alendronate is a bisphosphonate drug.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: alendronate
1. Bergstrom JD, Bostedor RG, Masarachia PJ, Reszka AA, Rodan G. (2000)
Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase.
Arch. Biochem. Biophys., 373 (1): 231-41. [PMID:10620343]
2. Dunford JE, Thompson K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, Ebetino FH, Rogers MJ. (2001)
Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.
J. Pharmacol. Exp. Ther., 296 (2): 235-42. [PMID:11160603]