ChEMBL ligand: CHEMBL870 (Acide alendronique, Acido alendronico, Alendronate, Alendronic acid, Alendronic Acid, Binosto, Fosamax)
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] There should be some charts here, you may need to enable JavaScript!
Farnesyl pyrophosphate synthase in Leishmania donovani [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7] Farnesyl pyrophosphate synthase in Leishmania major [ChEMBL: CHEMBL2150832] [UniProtKB: Q4QBL1] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21	B	6.41	pKi	393.1	nM	Ki	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL	Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand	B	7.04	pKi	91	nM	Ki	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	B	7.35	pKi	44.2	nM	Ki	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21	B	5.65	pIC50	2249	nM	IC50	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL	Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M)	B	6.02	pIC50	954.99	nM	IC50	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL	Inhibitory activity against farnesyl Pyrophosphate Synthase was determined	B	6.02	pIC50	950	nM	IC50	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL	Inhibition of human recombinant FPP synthase expressed in Escherichia coli S100 using FPP and IPP as substrates preincubated for 15 mins followed by substrate addition measured after 60 mins by scintillation counting analysis	B	6.34	pIC50	460	nM	IC50	J Med Chem (2021) 64: 9677-9710 [PMID:34236862]
GtoPdb	-	-	6.34	pIC50	460	nM	IC50	Arch Biochem Biophys (2000) 373: 231-41 [PMID:10620343]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	B	6.59	pIC50	260	nM	IC50	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
GtoPdb	In vitro inhibition of recombinant human protein expressed in E coli.	-	7.3	pIC50	50	nM	IC50	J Pharmacol Exp Ther (2001) 296: 235-42 [PMID:11160603]
ChEMBL	Inhibitory activity against the human recombinant FPPSase (Farnesyl diphosphate) enzyme	B	7.3	pIC50	50	nM	IC50	J Med Chem (2002) 45: 2185-2196 [PMID:12014956]
ChEMBL	Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation counting	B	7.3	pIC50	50	nM	IC50	J Med Chem (2011) 54: 5955-5980 [PMID:21780776]
Farnesyl pyrophosphate synthase in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7]
ChEMBL	Binding affinity towards Farnesyl diphosphate synthase from leishmania major	B	7.02	pKi	95	nM	Ki	J Med Chem (2005) 48: 2957-2963 [PMID:15828834]
Farnesyl pyrophosphate synthase in Leishmania major (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2150832] [UniProtKB: Q4QBL1]
ChEMBL	Inhibition of recombinant Leishmania major FPPS expressed in Escherichia coli BL21(DE3) using GPP and [14C]IPP as substrate incubated for 15 mins by scintillation counting method	B	7.04	pKi	91	nM	Ki	Bioorg Med Chem Lett (2020) 30: 127577-127577 [PMID:32979487]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]