[3H](+)-isradipine   Click here for help

GtoPdb Ligand ID: 2733

Synonyms: (+)-[3H]isradipine | (+)-[3H]O5-methyl O3-propan-2-yl 4-(2,1,3-benzoxadiazol-7-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate | 3H-(+)-PN 200-110
 Ligand is labelled  Ligand is radioactive
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 103.55
Molecular weight 371.15
XLogP 4.95
No. Lipinski's rules broken 0
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Canonical SMILES COC(=O)C1=C(C)NC(=C(C1c1cccc2c1non2)C(=O)OC(C)C)C
Isomeric SMILES COC(=O)C1=C(C)NC(=C([C@H]1c1cccc2c1non2)C(=O)OC(C)C)C
InChI InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3/t16-/m0/s1
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Biochemical characterization of plasma membrane isolated from human skeletal muscle.
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alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages.
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Increase of voltage-sensitive calcium channels and calcium accumulation in skeletal muscles of streptozocin-induced diabetic rats.
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Regional expression and functional characterization of the L-type Ca2+-channel in myocardium from patients with end-stage heart failure and in non-failing human hearts.
J Mol Cell Cardiol, 31 (1): 283-96. [PMID:10072735]
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Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels.
J Clin Invest, 113 (10): 1430-9. [PMID:15146240]