- Guide to PHARMACOLOGY
Compound class: Synthetic organic
Comment: Allyl isothiocyanate is a spicy component of wasabi. It acts as a transient receptor potential (TRP) cation channel activator.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A. (2004)
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin.
Neuron, 41 (6): 849-57. [PMID:15046718]
2. Hinman A, Chuang HH, Bautista DM, Julius D. (2006)
TRP channel activation by reversible covalent modification.
Proc Natl Acad Sci USA, 103 (51): 19564-8. [PMID:17164327]
3. Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Högestätt ED, Meng ID, Julius D. (2004)
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1.
Nature, 427 (6971): 260-5. [PMID:14712238]