- Guide to PHARMACOLOGY
Synonyms: Anplag® | LS-187,118 | MCI-9042
sarpogrelate is an approved drug
Compound class: Synthetic organic
Comment: Sarpogrelate is a 5-HT2A/ 5-HT2B receptor antagonist which blocks serotonin-induced platelet aggregation.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Muntasir HA, Hossain M, Bhuiyan MA, Komiyama T, Nakamura T, Ozaki M, Nagatomo T. (2007)
Identification of a key amino acid of the human 5-HT(2B) serotonin receptor important for sarpogrelate binding.
J Pharmacol Sci, 104 (3): 274-7. [PMID:17609583]
2. Nishio H, Inoue A, Nakata Y. (1996)
Binding affinity of sarpogrelate, a new antiplatelet agent, and its metabolite for serotonin receptor subtypes.
Arch Int Pharmacodyn Ther, 331 (2): 189-202. [PMID:8937629]
3. Pertz H, Elz S. (1995)
In-vitro pharmacology of sarpogrelate and the enantiomers of its major metabolite: 5-HT2A receptor specificity, stereoselectivity and modulation of ritanserin-induced depression of 5-HT contractions in rat tail artery.
J Pharm Pharmacol, 47 (4): 310-6. [PMID:7791029]
4. Rashid M, Manivet P, Nishio H, Pratuangdejkul J, Rajab M, Ishiguro M, Launay JM, Nagatomo T. (2003)
Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT2 antagonist, to human 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes by molecular modeling.
Life Sci, 73 (2): 193-207. [PMID:12738034]