sarpogrelate   Click here for help

GtoPdb Ligand ID: 210

Synonyms: Anplag® | LS-187,118 | MCI-9042
Approved drug
sarpogrelate is an approved drug
Compound class: Synthetic organic
Comment: Sarpogrelate is a 5-HT2A/ 5-HT2B receptor antagonist which blocks serotonin-induced platelet aggregation.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 14
Topological polar surface area 85.3
Molecular weight 429.22
XLogP 3.28
No. Lipinski's rules broken 1
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Canonical SMILES COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C
Isomeric SMILES COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C
InChI InChI=1S/C24H31NO6/c1-25(2)16-21(31-24(28)14-13-23(26)27)17-30-22-10-5-4-8-19(22)12-11-18-7-6-9-20(15-18)29-3/h4-10,15,21H,11-14,16-17H2,1-3H3,(H,26,27)
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Summary of Clinical Use Click here for help
May be used to reduce the risk of pathological thrombosis (clotting) in small and medium arteries and veins in many diseases including diabetes mellitus, Buerger's disease, Raynaud's disease, coronary artery disease, angina pectoris, and atherosclerosis. There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency websites. Individual national approval agencies may have granted marketing authorisation (principally South Korea and Japan).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
This drug blocks serotonin-induced platelet aggregation by antagonising the 5-HT2A and 5-HT2B receptors [1-3].