denufosol   Click here for help

GtoPdb Ligand ID: 1737

Synonyms: dCp4U | INS37217 | Up4dC
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 23
Hydrogen bond donors 9
Rotatable bonds 14
Topological polar surface area 429.51
Molecular weight 773.01
XLogP -6.56
No. Lipinski's rules broken 3
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Canonical SMILES Nc1ccn(c(=O)n1)C1OC(C(C1)O)COP(=O)(OP(=O)(OP(=O)(OP(=O)(OCC1OC(C(C1O)O)n1ccc(=O)[nH]c1=O)O)O)O)O
Isomeric SMILES Nc1ccn(c(=O)n1)[C@@H]1O[C@@H]([C@H](C1)O)COP(=O)(OP(=O)(OP(=O)(OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1ccc(=O)[nH]c1=O)O)O)O)O
InChI InChI=1S/C18H27N5O21P4/c19-11-1-3-22(17(28)20-11)13-5-8(24)9(40-13)6-38-45(30,31)42-47(34,35)44-48(36,37)43-46(32,33)39-7-10-14(26)15(27)16(41-10)23-4-2-12(25)21-18(23)29/h1-4,8-10,13-16,24,26-27H,5-7H2,(H,30,31)(H,32,33)(H,34,35)(H,36,37)(H2,19,20,28)(H,21,25,29)/t8-,9+,10+,13+,14+,15+,16+/m0/s1
1. Lazarowski ER, Watt WC, Stutts MJ, Brown HA, Boucher RC, Harden TK. (1996)
Enzymatic synthesis of UTP gamma S, a potent hydrolysis resistant agonist of P2U-purinoceptors.
Br J Pharmacol, 117 (1): 203-9. [PMID:8825364]
2. Pendergast W, Yerxa BR, Douglass 3rd JG, Shaver SR, Dougherty RW, Redick CC, Sims IF, Rideout JL. (2001)
Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates.
Bioorg Med Chem Lett, 11 (2): 157-60. [PMID:11206448]
3. Yerxa BR, Sabater JR, Davis CW, Stutts MJ, Lang-Furr M, Picher M, Jones AC, Cowlen M, Dougherty R, Boyer J et al.. (2002)
Pharmacology of INS37217 [P(1)-(uridine 5')-P(4)- (2'-deoxycytidine 5')tetraphosphate, tetrasodium salt], a next-generation P2Y(2) receptor agonist for the treatment of cystic fibrosis.
J Pharmacol Exp Ther, 302 (3): 871-80. [PMID:12183642]