peptide 5A

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Ligands
peptide 5A

GtoPdb Ligand ID: 10588

Compound class: Peptide or derivative

Comment: Peptide 5A is an apoA-I-mimetic that has been reported to reduce atherosclerosis [1], acute vascular inflammation, and oxidative stress in experimental animal models. It has subsequently been identified as an antagonistic ligand for the scavenger receptor CD36 and experimental evidence indicates that CD36 is its main pharmacological target [2].

References
1. Amar MJ, D'Souza W, Turner S, Demosky S, Sviridov D, Stonik J, Luchoomun J, Voogt J, Hellerstein M, Sviridov D et al.. (2010) 5A apolipoprotein mimetic peptide promotes cholesterol efflux and reduces atherosclerosis in mice. J Pharmacol Exp Ther, 334 (2): 634-41. [PMID:20484557]
2. Souza AC, Bocharov AV, Baranova IN, Vishnyakova TG, Huang YG, Wilkins KJ, Hu X, Street JM, Alvarez-Prats A, Mullick AE et al.. (2016) Antagonism of scavenger receptor CD36 by 5A peptide prevents chronic kidney disease progression in mice independent of blood pressure regulation. Kidney Int, 89 (4): 809-22. [PMID:26994575]

References

1. Amar MJ, D'Souza W, Turner S, Demosky S, Sviridov D, Stonik J, Luchoomun J, Voogt J, Hellerstein M, Sviridov D et al.. (2010)
5A apolipoprotein mimetic peptide promotes cholesterol efflux and reduces atherosclerosis in mice.
J Pharmacol Exp Ther, 334 (2): 634-41. [PMID:20484557]

2. Souza AC, Bocharov AV, Baranova IN, Vishnyakova TG, Huang YG, Wilkins KJ, Hu X, Street JM, Alvarez-Prats A, Mullick AE et al.. (2016)
Antagonism of scavenger receptor CD36 by 5A peptide prevents chronic kidney disease progression in mice independent of blood pressure regulation.
Kidney Int, 89 (4): 809-22. [PMID:26994575]