peptide 5A 
GtoPdb Ligand ID: 10588
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Compound class:
Peptide or derivative
Comment: Peptide 5A is an apoA-I-mimetic that has been reported to reduce atherosclerosis [1], acute vascular inflammation, and oxidative stress in experimental animal models. It has subsequently been identified as an antagonistic ligand for the scavenger receptor CD36 and experimental evidence indicates that CD36 is its main pharmacological target [2].
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| Bioactivity Comments |
| Peptide 5A slows chronic kidney disease progression and renal fibrosis in mouse models, and the disease-modifying effects are associated with decreased expression of inflammation and inflammasome-associated genes in renal tissue [2]. |
| Selectivity at other protein targets | ||||||||||||||||||||||||||||||||||
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