Compound class:
Synthetic organic
Comment: CDRI-97/78 is a novel trioxane peroxide with promising antimalarial activity [2]. It is a simplified analogue of artemisinin and retains the crucial endoperoxide bridge.
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References |
1. Shafiq N, Rajagopalan S, Kushwaha HN, Mittal N, Chandurkar N, Bhalla A, Kaur S, Pandhi P, Puri GD, Achuthan S et al.. (2014)
Single Ascending Dose Safety and Pharmacokinetics of CDRI-97/78: First-in-Human Study of a Novel Antimalarial Drug. Malar Res Treat, 2014: 372521. [PMID:24800100] |
2. Singh C, Puri SK. (2001)
Substituted 1,2,4-trioxanes as antimalarial agents and a process of producing the substituted 1,2,4-trioxanes. Patent number: US6316493B1. Assignee: Council of Scientific and Industrial Research. Priority date: 28/12/1999. Publication date: 13/11/2001. |