- Guide to PHARMACOLOGY
Synonyms: compound 3a [PMID: 30344903]
Compound class: Synthetic organic
Comment: Lys01 was developed for use as an antimalarial agent  and is also reported to be a potent inhibitor of autophagy .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. McAfee Q, Zhang Z, Samanta A, Levi SM, Ma XH, Piao S, Lynch JP, Uehara T, Sepulveda AR, Davis LE et al.. (2012)
Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency.
Proc Natl Acad Sci USA, 109 (21): 8253-8. [PMID:22566612]
2. Sakata Y, Yabunaka K, Kobayashi Y, Omiya H, Umezawa N, Kim HS, Wataya Y, Tomita Y, Hisamatsu Y, Kato N et al.. (2018)
Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme.
ACS Med Chem Lett, 9 (10): 980-985. [PMID:30344903]