(+)-SJ733

Ligand id: 9723

Name: (+)-SJ733

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 86.09
Molecular weight 468.12
XLogP 3.8
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Guide to Malaria Pharmacology Comments
(+)-SJ733 is equally potent against all developmental forms of the asexual blood stage parasite and also has potential for transmission blockade [1]. The compound was under clinical development as the fast clearance component of a single-exposure radical cure and prophylaxis (SERCaP) antimalarial drug but was found was found to have lower concentrations in humans than expected[2]. A back-up series, that has been informed by is being developed by the University of Kentucky that has been informed .

Potential Target/Mechanism Of Action: Evidence from genetic experiments indicates that Plasmodium non-SERCA-type Ca2+-transporting P-ATPase (PfATP4) may be the relevant molecular target [1]. Further information about possible mechanistic insights is provided under the Clinical data tab.
Target Candidate Profiles
Profile Intended Use Target Stage Comment References
TCP-5 transmission reduction gametocytes 1
TCP-1 reduce parasite burden asexual blood stages 1