- Guide to PHARMACOLOGY
Ligand id: 4800
View more information in the IUPHAR Pharmacology Education Project: pyrimethamine
Molecular properties generated using the CDK
|Guide to Malaria Pharmacology Comments|
|Pyrimethamine was developed at the beginning of the 1950s and was part of the work that led to the 1988 Nobel Prize in Physiology or Medicine being awarded to Gertrude Elion and George Hitchings for their discoveries of "important principles for drug treatment" . Resistance to the antifolate class of antimalarial drugs, including pyrimethamine, emerged soon after their clinical introduction and arisies from mutations in PfDHFR-TS .
Potential Target/Mechanism Of Action: Pyrimethamine inhibits Plasmodium dihydrofolate reductase-thymidylate synthase (DHFR-TS).