- Guide to PHARMACOLOGY
Compound class: Synthetic organic
Comment: BRD7929 is an advanced analogue from a bicyclic azetidine series of antimalarial compounds .
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Guide to Malaria Pharmacology Comments|
|BRD7929 was synthesized during optimization of BRD3444, the hit compound identified from a phenotypic screen of a Diversity-orientated synthesis library .
Potential Target/Mechanism Of Action: Correlation of purified cFRS IC50 values against parasite growth inhibition assays for a range of analogues, together with genetic evidence, indicate that PfcFRS is the relevant molecular target of this bicyclic azetidine series .