MMV019313   Click here for help

GtoPdb Ligand ID: 11456

Synonyms: TCMDC-123889
Antimalarial Ligand
Compound class: Synthetic organic
Comment: MMV019313 is a drug-like compound that was chosen as one of the chemotypes included in the MMV Malaria Box [3]. It is the first non-bisphosphonate inhibitor of P. falciparum bifunctional farnesyl/geranylgeranyl diphosphate synthase (PfFPPS/GGPPS) to be described and is highly selective for the Plasmodium target [1].

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 82.58
Molecular weight 397.18
XLogP 4.11
No. Lipinski's rules broken 0
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Canonical SMILES O=C(c1cc2c(s1)c1ccccc1n(c2=O)C)NCCCN1CCCCCC1
Isomeric SMILES O=C(c1cc2c(s1)c1ccccc1n(c2=O)C)NCCCN1CCCCCC1
InChI InChI=1S/C22H27N3O2S/c1-24-18-10-5-4-9-16(18)20-17(22(24)27)15-19(28-20)21(26)23-11-8-14-25-12-6-2-3-7-13-25/h4-5,9-10,15H,2-3,6-8,11-14H2,1H3,(H,23,26)
Guide to Malaria Pharmacology Comments
MMV019313 has been used to inform the development of a series of novel thiazole-containing amides that are potent and selective inhibitors of PfFPPS/GGPPS, with the most promising candidate AIM-1290 demonstrating an improved in vitro ADME profile [2].

Potential Target/Mechanism Of Action: the molecular target of MMV019313 is P. falciparum bifunctional farnesyl/geranylgeranyl diphosphate synthase (PfFPPS/GGPPS) with molecular docking studies indicating that MMV019313 binds to a new, selective small-molecule binding site [1].