Synonyms: TCMDC-123889
Compound class:
Synthetic organic
Comment: MMV019313 is a drug-like compound that was chosen as one of the chemotypes included in the MMV Malaria Box [3]. It is the first non-bisphosphonate inhibitor of P. falciparum bifunctional farnesyl/geranylgeranyl diphosphate synthase (PfFPPS/GGPPS) to be described and is highly selective for the Plasmodium target [1].
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. ![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Guide to Malaria Pharmacology Comments |
MMV019313 has been used to inform the development of a series of novel thiazole-containing amides that are potent and selective inhibitors of PfFPPS/GGPPS, with the most promising candidate AIM-1290 demonstrating an improved in vitro ADME profile [2]. Potential Target/Mechanism Of Action: the molecular target of MMV019313 is P. falciparum bifunctional farnesyl/geranylgeranyl diphosphate synthase (PfFPPS/GGPPS) with molecular docking studies indicating that MMV019313 binds to a new, selective small-molecule binding site [1]. |