Ligand id: 10410

Name: MK-4815

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 46.25
Molecular weight 235.19
XLogP 4.8
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Guide to Malaria Pharmacology Comments
MK-4815 was identified by a phenotypic whole cell high-throughput screen of the Merck proprietary compound collection and considered to have potential as a therapy for acute P. falciparum malaria [2], although it has not progressed beyond preclinical testing due to a narrow safety window [1].

Potential Target/Mechanism Of Action: As the precise MOA of MK-4815 is not yet known, we do not have a molecular target for this compound.