cladosporin

Ligand id: 10247

Name: cladosporin

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 75.99
Molecular weight 292.13
XLogP 2.56
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Guide to Malaria Pharmacology Comments
Although cladosporin exhibits potent antimalarial activity, poor oral bioavailability has precluded the compound from further advancement in the antimalarial drug development pipeline. A recent SAR study has identified a simplified cladosporin analogue (compound 28) that has higher antimalarial potency and improved metabolic stability [2].

Potential Target/Mechanism Of Action: Postgenomic methods indicate that cladosporin inhibits protein synthesis by directly targeting P. falciparum lysine--tRNA ligase (PfKRS1) [1].