- Guide to PHARMACOLOGY
Molecular properties generated using the CDK
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Guide to Malaria Pharmacology Comments|
|The use of halofuginone as an antimalarial medicine is precluded by intolerable side-effects and it is used instead as an antiprotozoal agent in veterinary medicine.
Potential Target/Mechanism Of Action: halofuginone activates the amino acid response pathway by direct inhibition of the PfPRS activity of glutamyl-prolyl tRNA synthetase (EPRS) .