Ligand id: 10153

Name: halofuginone

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 84.22
Molecular weight 413.01
XLogP 2.81
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Guide to Malaria Pharmacology Comments
The use of halofuginone as an antimalarial medicine is precluded by intolerable side-effects and it is used instead as an antiprotozoal agent in veterinary medicine.

Potential Target/Mechanism Of Action: halofuginone activates the amino acid response pathway by direct inhibition of the PfPRS activity of glutamyl-prolyl tRNA synthetase (EPRS) [2].