- Guide to PHARMACOLOGY
Synonyms: receptor activator of nuclear factor κB ligand | osteoclast differentiation factor (ODF) | osteoprotegerin ligand | TNFSF11
Compound class: Endogenous peptide in human, mouse or rat
Comment: RANK ligand (TNFSF11) is a member of the tumor necrosis factor (TNF) cytokine family. It can exist in both membrane-bound and soluble forms. It is a key factor for osteoclast differentiation and activation. Osteoprotegerin acts as a decoy receptor for RANK ligand.
|RANK ligand acts as a dentritic cell survival factor and is involved in regulation of the T cell-dependent immune response.|
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