primaquine

Ligand id: 9952

Name: primaquine

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 60.17
Molecular weight 259.17
XLogP 2.09
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Primaquine has a broad spectrum of antimalarial activity and has a number of uses: primary prophylaxis against all Plasmodium species, terminal prophylaxis for P. vivax and P. ovale exposure, and as a radical cure (in combination with an effective blood stage schizonticide) after P. vivax or P. ovale clinical disease [2]. In addition, a recent WHO policy update, recommends the use of primaquine as a gametocytocide to reduce P. falciparum malaria transmission from human to mosquito host.
Testing for glucose-6-phosphate dehydrogenase (G6PD) deficiency is required before administration because primaquine causes haemolysis in genetically sensitive individuals [3].
Pharmacokinetics
Elimination
Primaquine has a terminal half-life for elimination in the 2-12 hour range [2].
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