primaquine

Ligand id: 9952

Name: primaquine

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 60.17
Molecular weight 259.17
XLogP 2.09
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Whole organism assay data
Key to terms and symbols Click on species/strain names for details Click column headers to sort
MOA/likely target Sp. Assay description Type Action Value Parameter Concentration range (M) Reference
Unknown MOA Pf7G8 Parasite growth inhibition assay - - 6.4 pIC50 - 1
pIC50 6.4 (IC50 4.413x10-7 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Unknown MOA PfV1/S Parasite growth inhibition assay - - 6.3 pIC50 - 1
pIC50 6.3 (IC50 5.427x10-7 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Unknown MOA Pc Parasite liver stage assay - - 6.1 – 6.4 pIC50 - 4
pIC50 6.4 (IC50 3.7x10-7 M) P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of schizonts at 10µM [4]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
pIC50 6.1 (IC50 8.4x10-7 M) P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of hypnozoites at 10µM [4]
Lifecycle stages: Plasmodium dormant liver stage (hypnozoite)
Unknown MOA PfK1 Parasite growth inhibition assay - - 6.3 pIC50 - 1
pIC50 6.3 (IC50 5.57x10-7 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Unknown MOA PfTM90C2A Parasite growth inhibition assay - - 6.2 pIC50 - 1
pIC50 6.2 (IC50 6.297x10-7 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Unknown MOA PfW2 Parasite growth inhibition assay - - 6.2 pIC50 - 1
pIC50 6.2 (IC50 6.757x10-7 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Unknown MOA PfNF54 Parasite growth inhibition assay - - 5.9 pIC50 - 1
pIC50 5.9 (IC50 1.191x10-6 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Unknown MOA PfD6 Parasite growth inhibition assay - - 5.8 pIC50 - 1
pIC50 5.8 (IC50 1.518x10-6 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)