- Guide to PHARMACOLOGY
Synonyms: compound 32 [PMID: 26861551]
Compound class: Synthetic organic
Comment: GSK2245035 is reported as a selective Toll-like receptor 7 (TLR7) agonist, with potential clinical action as an intranasally administered anti-asthmatic . It is Example 22 claimed in patent WO2010018133 .
The TLR7- IFNα pathway is a novel pathway being investigated for pharmacological intervention in allergic asthma.
|No information available.|
|Summary of Clinical Use|
|GSK2245035 has completed Phase 2 clinical trials in patients with asthma and allergic rhinitis. Results from early clinical evaluation in trials for allergic rhinitis, NCT01480271 (Phase 1) and NCT01607372 (Phase 2), are reported in , and results from NCT02446613 reported in .|
|Mechanism Of Action and Pharmacodynamic Effects|
|Application of TLR agonists directly to the primary site of allergen exposure in the upper airways is a recent development in the search for novel treatments for respiratory allergies  (e.g. TLR7 selective agonist AZD8848  and TLR8 selective agonist VTX-1463).|