Synonyms: compound 32 [PMID: 26861551]
Compound class:
Synthetic organic
Comment: GSK2245035 is reported as a selective Toll-like receptor 7 (TLR7) agonist, with potential clinical action as an intranasally administered anti-asthmatic [2]. It is Example 22 claimed in patent WO2010018133 [3].
The TLR7- IFNα pathway is a novel pathway being investigated for pharmacological intervention in allergic asthma. |
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Immunopharmacology Comments |
GSK2245035 is a highly selective TLR7 agonist that preferentially stimulates the induction of type I interferons. |
Immunopharmacology Disease | |||
Disease | X-Refs | Comment | References |
Asthma |
Disease Ontology:
DOID:2841 OMIM: 600807 |
Experimental compound with clinical potential in asthma. | |
Allergic rhinitis |
Disease Ontology:
DOID:4481 |
Phase 2 clinical candidate for allergic rhinitis- administered intranasally. | 4 |