cilnidipine   Click here for help

GtoPdb Ligand ID: 7767

Synonyms: FRC-8653
Approved drug
cilnidipine is an approved drug
Compound class: Synthetic organic
Comment: Cilnidipine is a calcium channel blocking antihypertensive drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 12
Topological polar surface area 117
Molecular weight 492.19
XLogP 5.43
No. Lipinski's rules broken 2
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Canonical SMILES COCCOC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCC=Cc1ccccc1)C
Isomeric SMILES COCCOC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OC/C=C/c1ccccc1)C
InChI InChI=1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+
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Summary of Clinical Use Click here for help
Cilnidipine is to treat hypertension. According to the website this compound has marketing approval in Japan (AtelecTN, CinalongTN), China (JiuyueTN), South Korea (CinalongTN) and India (CilacarTN).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Cilnidipine blocks activity of N-type and L-type calcium channels. This causes dilateion of both arterioles and venules to bring about a reducetion in blood pressure.