cilnidipine [Ligand Id: 7767] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL452076 (Atelec, Cilnidipine, Cinalong, FRC-8653, Siscard) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936] | ||||||||
| ChEMBL | Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in Xenopus oocyte heterologically expressing alpha-1C subunit | F | 4.9 | pIC50 | 12700 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
| ChEMBL | Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in Xenopus oocyte heterologically expressing alpha-1C subunit | F | 5.28 | pIC50 | 5300 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
| Cav2.2/Voltage-gated N-type calcium channel alpha-1B subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4478] [GtoPdb: 533] [UniProtKB: Q00975] | ||||||||
| ChEMBL | Inhibition of human N type calcium channel Cav2.2 endogenously expressed in SH-SY5Y cells assessed as calcium influx by FRIPR assay | B | 4.59 | pIC50 | 26000 | nM | IC50 | Bioorg Med Chem (2020) 28: 115655-115655 [PMID:32828422] |
| ChEMBL | Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging assay | B | 4.59 | pIC50 | 26000 | nM | IC50 | RSC Med Chem (2022) 13: 183-195 [PMID:35308021] |
| ChEMBL | Inhibitory activity against N-type calcium channel by calcium influx into IMR32 cells | F | 5.8 | pIC50 | 1600 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 798-802 [PMID:16309909] |
| Cav2.2 in Rat [GtoPdb: 533] [UniProtKB: Q02294] | ||||||||
| GtoPdb | - | - | 6.7 | pIC50 | - | - | - | J Pharmacol Exp Ther (1997) 280: 1184-91 [PMID:9067302] |
| Cav3.2/Voltage-gated T-type calcium channel alpha-1H subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1859] [GtoPdb: 536] [UniProtKB: O95180] | ||||||||
| ChEMBL | Inhibition of human T type calcium channel Cav3.2 expressed in HEK-293T cells assessed as calcium influx by FRIPR assay | B | 4.62 | pIC50 | 24000 | nM | IC50 | Bioorg Med Chem (2020) 28: 115655-115655 [PMID:32828422] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
