Synonyms: CIPsMBP | Skelid® | SR-41319 | tiludronate
tiludronic acid is an approved drug
Compound class:
Synthetic organic
Comment: Tiludronic acid belongs to the same non-nitrogenous bisphosphonate drug family as etidronic acid and clodronic acid (PubChem CID 25419). Marketed formulations contain tiludronate disodium (PubChem CID 60936).
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖![]() View more information in the IUPHAR Pharmacology Education Project: tiludronic acid |
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No information available. |
Mechanism Of Action and Pharmacodynamic Effects ![]() |
Bisphosphonates bind to hydroxyapatite in calcified bone matrix and inhibit the activity of enzymes that utilize pyrophosphate. Non-nitrogenous bisphosphonates such as tiludronic acid are metabolised in osteoclasts to compounds that form non-functional ATP molecules. This non-functional ATP then competes with active ATP in energy metabolism within the cell. The effect is reduced energy metabolism which drives the osteoclasts into apoptotic cell death. The net drug-induced effect is inhibition of osteoclast-driven bone resorption [1]. |