perospirone   Click here for help

GtoPdb Ligand ID: 7556

Synonyms: Lullan® (Japan)
Approved drug
perospirone is an approved drug
Compound class: Synthetic organic
Comment: Perospirone is an azapirone class atypical (second generation) antipsychotic. A higher incidence of extrapyramidal side-effects is associated with perospirone use than with other atypical antipsychotics, but fewer than reported with typical (first generation) antipsychotics.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 84.99
Molecular weight 426.21
XLogP 3.7
No. Lipinski's rules broken 0
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Canonical SMILES O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)C2C1CCCC2
Isomeric SMILES O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2
InChI InChI=1S/C23H30N4O2S/c28-22-17-7-1-2-8-18(17)23(29)27(22)12-6-5-11-25-13-15-26(16-14-25)21-19-9-3-4-10-20(19)30-24-21/h3-4,9-10,17-18H,1-2,5-8,11-16H2/t17-,18+
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Summary of Clinical Use Click here for help
Used to treat schizophrenia. However, there is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency (EMA) websites. Individual national approval agencies may have granted marketing authorisation. The international drug listing on the FDA website only lists China and Japan as countries where this drug may be used.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
This drug has multifunctional activity. It has been reported as an antagonist at dopamine D1, D2 and D3 receptors, serotonin 5-HT2 and 5-HT3 receptors, α1-adrenoceptors and a partial agonist at the 5-HT1A receptor. The combined effect of this is to improve psychotic symptoms.