perospirone [Ligand Id: 7556] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1472975 (Perospirone)
  • 5-HT2A receptor in Rat [GtoPdb: 6] [UniProtKB: P14842]
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  • D2 receptor in Human [GtoPdb: 215] [UniProtKB: P14416]
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  • D3 receptor in Human [GtoPdb: 216] [UniProtKB: P35462]
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  • D4 receptor in Human [GtoPdb: 217] [UniProtKB: P21917]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT2A receptor in Rat [GtoPdb: 6] [UniProtKB: P14842]
GtoPdb - - 4.74 pKi 18000 nM Ki Proc Natl Acad Sci USA (1975) 72: 4376-80 [PMID:1060115]
D2 receptor in Human [GtoPdb: 215] [UniProtKB: P14416]
GtoPdb - - 9.22 pKi 0.6 nM Ki Proc Natl Acad Sci USA (1975) 72: 4376-80 [PMID:1060115]
D3 receptor in Human [GtoPdb: 216] [UniProtKB: P35462]
GtoPdb - - 9.55 pKi 0.28 nM Ki Eur J Pharmacol (1992) 225: 331-7 [PMID:1354163]
D4 receptor in Human [GtoPdb: 217] [UniProtKB: P21917]
GtoPdb - - 10.05 pKi 0.09 nM Ki Mol Psychiatry (1998) 3: 123-34 [PMID:9577836]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]