esmolol   Click here for help

GtoPdb Ligand ID: 7178

Synonyms: Brevibloc® | SL-8052
Approved drug
esmolol is an approved drug (FDA (1986))
Compound class: Synthetic organic
Comment: Esmolol is a β-blocker.
Marketed formulations may contain esmolol hydrochloride (PubChem CID 104769).
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View more information in the IUPHAR Pharmacology Education Project: esmolol

2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 67.79
Molecular weight 295.18
XLogP 1.68
No. Lipinski's rules broken 0
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Canonical SMILES COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O
Isomeric SMILES COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O
InChI InChI=1S/C16H25NO4/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3
No information available.
Summary of Clinical Use Click here for help
Esmolol is indicated for the treatment of acute supraventricular tachycardia, atrial fibrillation or atrial flutter.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Esmolol anatgonises β1-adrenoceptors in the sympathetic system. This prevents the receptors from processing signals from endogenous epinephrine and norepinephrine resulting in decreased force of heart contractions and lowered heart rate. See the DrugBank link for further details.
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