esmolol [Ligand Id: 7178] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL768 (ASL-8052-001, Esmolol) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| GtoPdb | - | - | 6.9 | pKi | - | - | - |
National Toxicology Program: Dept of Health and Human Services.. DrugMatrix; J Pharmacol Exp Ther (2016) 359: 73-81 [PMID:27451411] |
| ChEMBL | DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) | B | 6.94 | pKi | 113.7 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) | B | 6.71 | pIC50 | 197 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Beta-1 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73] | ||||||||
| ChEMBL | Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation | B | 7 | pKd | 100 | nM | Kd | J Med Chem (1982) 25: 1408-1412 [PMID:6130154] |
| ChEMBL | Activity at beta-1 adrenergic receptor | B | 7 | pKd | 100 | nM | Kd | J Med Chem (1992) 35: 4676-4682 [PMID:1361581] |
| Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4] | ||||||||
| ChEMBL | Ability to block Beta-2 adrenergic receptor in guinea pig trachea preparation | B | 5.2 | pKd | 6309.57 | nM | Kd | J Med Chem (1982) 25: 1408-1412 [PMID:6130154] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
