disopyramide   Click here for help

GtoPdb Ligand ID: 7167

Synonyms: Norpace® | Rythmodan® | SC-13957 | SC-7031
Approved drug
disopyramide is an approved drug (FDA (1977))
Compound class: Synthetic organic
Comment: Marketed formulations may containdisopyramide phosphate (PubChem CID 30928).
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View more information in the IUPHAR Pharmacology Education Project: disopyramide

2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 60.21
Molecular weight 339.23
XLogP 4.62
No. Lipinski's rules broken 0
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Canonical SMILES CC(N(C(C)C)CCC(c1ccccn1)(c1ccccc1)C(=N)O)C
Isomeric SMILES CC(N(C(C)C)CCC(c1ccccn1)(c1ccccc1)C(=N)O)C
InChI InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25)
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Summary of Clinical Use Click here for help
Used to treat cardiac arrhythmias.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
This drug stabilises the cardiac membrane by binding to sodium channels, and decreasing permeability to Na+ ions. This blocks initiation and conductance of nerve impulses. CHEMBL report that this drug acts by blocking sodium channel α subunits (genes SNC1A-SNC11A are listed in this database in the Voltage-gated sodium channels section).
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