disopyramide   Click here for help

GtoPdb Ligand ID: 7167

Synonyms: Norpace® | Rythmodan® | SC-13957 | SC-7031
Approved drug
disopyramide is an approved drug (FDA (1977))
Compound class: Synthetic organic
Comment: Marketed formulations may containdisopyramide phosphate (PubChem CID 30928).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 60.21
Molecular weight 339.23
XLogP 4.62
No. Lipinski's rules broken 0
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Canonical SMILES CC(N(C(C)C)CCC(c1ccccn1)(c1ccccc1)C(=N)O)C
Isomeric SMILES CC(N(C(C)C)CCC(c1ccccn1)(c1ccccc1)C(=N)O)C
InChI InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25)
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kv11.1 Hs Channel blocker Inhibition 4.0 pIC50 - 1
pIC50 4.0 (IC50 9.12x10-5 M) [1]