benzquinamide   Click here for help

GtoPdb Ligand ID: 7124

Synonyms: P-2647 | Quantril®
Approved drug
benzquinamide is an approved drug
Compound class: Synthetic organic
Comment: Benzquinamide is a largely discontinued antiemetic drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 68.31
Molecular weight 404.23
XLogP 1.69
No. Lipinski's rules broken 0
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Canonical SMILES CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC
Isomeric SMILES CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC
InChI InChI=1S/C22H32N2O5/c1-6-23(7-2)22(26)17-13-24-9-8-15-10-20(27-4)21(28-5)11-16(15)18(24)12-19(17)29-14(3)25/h10-11,17-19H,6-9,12-13H2,1-5H3
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Summary of Clinical Use Click here for help
Primarily used as an antiemetic following anesthesia. Use has been discontinued in some countries and there is no information regarding current approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Appears to antagonise muscarinic acetycholine receptors and also histamine H1 receptors.