ricolinostat   Click here for help

GtoPdb Ligand ID: 7010

Synonyms: ACY-1215
PDB Ligand
Compound class: Synthetic organic
Comment: Rocilinostat is an investigational HDAC6 inhibitor [2]. But note that it exhibits only ~10-fold enzymic selectivity against the class I isoform, HDAC1.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 13
Topological polar surface area 107.45
Molecular weight 433.21
XLogP 3.74
No. Lipinski's rules broken 1
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Canonical SMILES ONC(=O)CCCCCCNC(=O)c1cnc(nc1)N(c1ccccc1)c1ccccc1
Isomeric SMILES ONC(=O)CCCCCCNC(=O)c1cnc(nc1)N(c1ccccc1)c1ccccc1
InChI InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30)
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Summary of Clinical Use Click here for help
Click here to link to ClinicalTrials.gov's full list of ricolinostat studies.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Rocilinostat inhibits HDAC6 >10 fold more potently than any other HDAC isozyme [2]. Selective inhibition of the class II HDAC isoforms, such as HDAC6, is believed to have the potential to circumvent the reported toxicity associated with inhibition of the class I isoforms [1].