acetazolamide   Click here for help

GtoPdb Ligand ID: 6792

Synonyms: Diamox®
Approved drug PDB Ligand
acetazolamide is an approved drug (FDA (1995))
Compound class: Synthetic organic
Comment: Carbonic anhydrase inhibitor
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 151.66
Molecular weight 221.99
XLogP -0.98
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CC(=O)Nc1nnc(s1)S(=O)(=O)N
Isomeric SMILES CC(=O)Nc1nnc(s1)S(=O)(=O)N
InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
InChI Key BZKPWHYZMXOIDC-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
Used to treat certain types of glaucoma, epilepsy, or edema (fluid buildup) in combination with other medicines. Decreases fluid build-up/pressure in the eyeball (glaucoma) and acts as a diuretic in the kidneys, increasing fluid removel. Antiepileptic effect is believed to be due to inhibition of carbonic anhydrase in the brain which results in increased inhibition of transneuronal signal transduction, via increased chloride current.
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