ChEMBL ligand: CHEMBL20 (Acetamox, Acetazolamida, Acetazolamide, Acetazolamidum, Atenezo, Defiltran, Diamox, Diamox sr, Didoc, Diuriwas, Donmox, Edemox, Eytazox, Glaupax, L 579486, Nephramide, NSC-145177, Phonurit)
AGAP002992-PA in Anopheles gambiae [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56] There should be some charts here, you may need to enable JavaScript!
Alpha carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02] There should be some charts here, you may need to enable JavaScript!
Astrosclerin-3 in Astrosclera willeyana [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1] There should be some charts here, you may need to enable JavaScript!
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase in Mycobacterium tuberculosis [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9] Carbonic anhydrase in Methanosarcina thermophila [ChEMBL: CHEMBL3932] [UniProtKB: P40881] Carbonic anhydrase in Flaveria bidentis [ChEMBL: CHEMBL2401609] [UniProtKB: P46510] Carbonic anhydrase in Dicentrarchus labrax [ChEMBL: CHEMBL1795125] [UniProtKB: Q2PCB5] Carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24] Carbonic anhydrase in Methanobacterium thermoautotrophicum [ChEMBL: CHEMBL3926] [UniProtKB: Q50565] Carbonic anhydrase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) [ChEMBL: CHEMBL3596083] [UniProtKB: Q9HVB9] Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71] Carbonic anhydrase in Candida glabrata CBS 138 [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6] Carbonic anhydrase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5931] [UniProtKB: P53615] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 1 in Drosophila melanogaster [ChEMBL: CHEMBL2331046] [UniProtKB: Q9V396] Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) [ChEMBL: CHEMBL4211] [UniProtKB: O24855] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 15 in Mouse [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 2, isoform A in Drosophila melanogaster [ChEMBL: CHEMBL2331045] [UniProtKB: Q9VTU8] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 3 in Bovine [ChEMBL: CHEMBL1944498] [UniProtKB: Q3SZX4] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] Carbonic anhydrase II in Bovine [ChEMBL: CHEMBL2283] [UniProtKB: P00921] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase III in Human [ChEMBL: CHEMBL2885] [UniProtKB: P07451] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] Carbonic anhydrase IV in Bovine [ChEMBL: CHEMBL281] [UniProtKB: Q95323] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase-related protein 2 in Human [ChEMBL: CHEMBL2420] [UniProtKB: O75493] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase VB in Human [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase VI in Human [ChEMBL: CHEMBL3025] [UniProtKB: P23280] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] carbonic anhydrase 7/Carbonic anhydrase VII in Mouse [ChEMBL: CHEMBL2216] [GtoPdb: 2749] [UniProtKB: Q9ERQ8] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 13/Carbonic anhydrase XIII in Human [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1] carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] There should be some charts here, you may need to enable JavaScript!
Delta carbonic anhydrase in Thalassiosira weissflogii [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1] There should be some charts here, you may need to enable JavaScript!
Endochitinase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL1293195] [UniProtKB: P29029] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis [ChEMBL: CHEMBL5767] [UniProtKB: P96878] There should be some charts here, you may need to enable JavaScript!
Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56]
ChEMBL	Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.56	pKi	27.3	nM	Ki	Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523]
Alpha carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02]
ChEMBL	Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL	Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1]
ChEMBL	Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	B	7.29	pKi	51	nM	Ki	Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172]
ChEMBL	Inhibition of Astrosclera willeyana recombinant GST-tagged astrosclerin 3 expressed in Escherichia coli BL21-DE3-RIPL cells preincubated for 15 mins measured for 10 to 100 secs by stopped flow CO2 hydration assay	B	7.29	pKi	51	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1314-1316 [PMID:22227210]
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3]
ChEMBL	Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay	B	8.35	pKi	4.5	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
Carbonic anhydrase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9]
ChEMBL	Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay	B	8.05	pKi	9	nM	Ki	Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301]
Carbonic anhydrase in Methanosarcina thermophila (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3932] [UniProtKB: P40881]
ChEMBL	Inhibitory activity against alpha carbonic anhydrase (Co-Cam) from Methanosarcina thermophila	B	5.84	pKi	1430	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibition of Methanosarcina thermophila recombinant gamma-CA by CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL	Inhibition of archaeon Methanosarcina thermophila gamma-CA after 15 mins by stopped-flow/Co2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2015) 23: 4405-4409 [PMID:26145820]
ChEMBL	Inhibition of Methanosarcina thermophila gamma carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2016) 24: 3413-3417 [PMID:27283786]
ChEMBL	Inhibition of Methanosarcina thermophila recombinant carbonic anhydrase gamma assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2017) 25: 575-580 [PMID:27914949]
ChEMBL	Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila	B	7.22	pKi	60	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
Carbonic anhydrase in Flaveria bidentis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2401609] [UniProtKB: P46510]
ChEMBL	Inhibition of Flaveria bidentis recombinant CA by CO2 hydration assay	B	7.57	pKi	27	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL	Inhibition of Flaveria bidentis carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.57	pKi	27	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6706-6710 [PMID:24210500]
ChEMBL	Inhibition of Flaveria bidentis carbonic anhydrase-1 by CO2 hydration reaction based colorimetric stopped-flow method	B	7.57	pKi	27	nM	Ki	Bioorg Med Chem (2015) 23: 4831-4838 [PMID:26068018]
ChEMBL	Inhibition of Flaveria bidentis carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.57	pKi	27	nM	Ki	Bioorg Med Chem (2016) 24: 3413-3417 [PMID:27283786]
Carbonic anhydrase in Dicentrarchus labrax (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795125] [UniProtKB: Q2PCB5]
ChEMBL	Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assay	B	5.24	pKi	5720	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522]
Carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24]
ChEMBL	Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
Carbonic anhydrase in Methanobacterium thermoautotrophicum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3926] [UniProtKB: Q50565]
ChEMBL	Inhibitory activity against beta carbonic anhydrase (Cab) from Methanobacterium thermoautotrophicum	B	4.92	pKi	12100	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibition of Methanobacterium thermoautotrophicum carbonic anhydrase by stopped flow CO2 hydration method	B	4.92	pKi	12100	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of Methanothermobacter thermautotrophicus carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay	B	4.92	pKi	12100	nM	Ki	Bioorg Med Chem (2011) 19: 243-248 [PMID:21163660]
ChEMBL	Inhibition of Methanobacterium thermoautotrophicum beta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	B	4.92	pKi	12100	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6706-6710 [PMID:24210500]
Carbonic anhydrase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3596083] [UniProtKB: Q9HVB9]
ChEMBL	Inhibition of Pseudomonas aeruginosa PAO1 type-2 beta-carbonic anhydrase psCA3 expressed in Escherichia coli Tuner BL21 (DE3) cells pre-incubated for 15 mins at pH 8.3 and 293K by CO2 hydration reaction based colorimetric stopped-flow method	B	7.12	pKi	75.9	nM	Ki	Bioorg Med Chem (2015) 23: 4831-4838 [PMID:26068018]
Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71]
ChEMBL	Inhibition of recombinant Candida albicans beta carbonic anhydrase NCE103 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.88	pKi	132	nM	Ki	Bioorg Med Chem (2016) 24: 1648-1652 [PMID:26951893]
ChEMBL	Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay	B	6.88	pKi	132	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	inhibition of Candida albicans recombinant Nce103 after 15 mins by stopped-flow CO2 hydration assay	B	6.88	pKi	132	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2508-2511 [PMID:20299219]
ChEMBL	Inhibition of Candida albicans recombinant Carbonic anhydrase pre-incubated for 15 mins by CO2 hydration stopped-flow assay	B	6.88	pKi	132	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2642-2645 [PMID:19375309]
ChEMBL	Inhibition of Candida albicans carbonic anhydrase preincubated for 15 mins at pH 8.3 by stopped flow CO2 hydration method	B	6.88	pKi	132	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	6.88	pKi	132	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL	Inhibition of Candida albicans recombinant Nce103 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay	B	6.89	pKi	130	nM	Ki	J Med Chem (2011) 54: 1682-1692 [PMID:21332115]
Carbonic anhydrase in Candida glabrata CBS 138 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6]
ChEMBL	Inhibition of Candida glabrata carbonic anhydrase by stopped flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4802-4805 [PMID:19574046]
ChEMBL	Inhibition of Candida glabrata CgNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	7.96	pKi	11	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL	Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2013) 23: 2647-2652 [PMID:23511020]
ChEMBL	Inhibition of recombinant Candida glabrata beta carbonic anhydrase NCE103 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2016) 24: 1648-1652 [PMID:26951893]
ChEMBL	Inhibition of Candida glabrata Nce103 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.96	pKi	11	nM	Ki	ACS Med Chem Lett (2017) 8: 1194-1198 [PMID:29152053]
Carbonic anhydrase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5931] [UniProtKB: P53615]
ChEMBL	Inhibition of Saccharomyces cerevisiae carbonic anhydrase by oxygen-18 isotope exchange assay	B	4.8	pKi	16000	nM	Ki	Bioorg Med Chem Lett (2008) 18: 6327-6331 [PMID:18993072]
ChEMBL	Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay	B	7.08	pKi	82.6	nM	Ki	Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL	Inhibition of Saccharomyces cerevisiae beta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.09	pKi	82	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1626-1630 [PMID:23414801]
ChEMBL	Inhibition of Saccharomyces cerevisiae carbonic anhydrase SceCA preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.09	pKi	82	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6706-6710 [PMID:24210500]
ChEMBL	Inhibition of Saccharomyces cerevisiae carbonic anhydrase by CO2 hydration reaction based colorimetric stopped-flow method	B	7.09	pKi	82	nM	Ki	Bioorg Med Chem (2015) 23: 4831-4838 [PMID:26068018]
Carbonic anhydrase 1 in Drosophila melanogaster (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331046] [UniProtKB: Q9V396]
ChEMBL	Inhibition of Drosophila melanogaster recombinant carbonic anhydrase-1 expressed in Escherichia coli BL21 (DE3) preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.97	pKi	106	nM	Ki	Bioorg Med Chem (2013) 21: 1516-1521 [PMID:22989910]
Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4211] [UniProtKB: O24855]
ChEMBL	Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay	B	7.68	pKi	21	nM	Ki	J Med Chem (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL	Inhibition of Helicobacter pylori recombinant CA	B	7.7	pKi	20	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077]
Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23]
ChEMBL	Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay	B	7.14	pKi	72	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3593-3596 [PMID:18501600]
ChEMBL	Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay	B	7.14	pKi	72	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration assay	B	7.14	pKi	72	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of mouse recombinant CA15 by stopped flow CO2 hydrase assay	B	7.14	pKi	72	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of full length mouse carbonic anhydrase 15 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.14	pKi	72	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of mouse recombinant carbonic anhydrase 15 after 15 mins by stopped-flow CO2 hydration assay	B	7.14	pKi	72	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration method	B	7.14	pKi	72	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of mouse CA15 by stopped-flow CO2 hydrase assay	B	7.14	pKi	72	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7]
ChEMBL	Inhibition of Cryptococcus neoformans Can2 assessed as CO2 hydrase activity by stopped-flow assay	B	7.98	pKi	10.5	nM	Ki	Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL	Inhibition of Cryptococcus neoformans var. grubii beta-carbonic anhydrase incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.98	pKi	10.5	nM	Ki	Bioorg Med Chem (2015) 23: 4181-4187 [PMID:26145821]
ChEMBL	Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	7.98	pKi	10.5	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL	Inhibition of Cryptococcus neoformans recombinant Can2 by CO2 hydration assay	B	7.98	pKi	10.5	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL	Inhibition of Cryptococcus neoformans carbonic anhydrase Can2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.98	pKi	10.5	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6706-6710 [PMID:24210500]
ChEMBL	Inhibition of Cryptococcus neoformans beta-carbonic anhydrase Can2	B	7.98	pKi	10.5	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1127-1132 [PMID:24461298]
ChEMBL	Inhibition of Cryptococcus neoformans Can2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	8	pKi	10	nM	Ki	ACS Med Chem Lett (2017) 8: 1194-1198 [PMID:29152053]
ChEMBL	Inhibition of Cryptococcus neoformans beta carbonic anhydrase Can2 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique	B	8	pKi	10	nM	Ki	Bioorg Med Chem Lett (2012) 22: 5801-5806 [PMID:22901388]
ChEMBL	Inhibition of Cryptococcus neoformans recombinant Can2 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay	B	8	pKi	10	nM	Ki	J Med Chem (2011) 54: 1682-1692 [PMID:21332115]
Carbonic anhydrase 2, isoform A in Drosophila melanogaster (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331045] [UniProtKB: Q9VTU8]
ChEMBL	Inhibition of Drosophila melanogaster recombinant carbonic anhydrase-2 expressed in Escherichia coli BL21 (DE3) preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.11	pKi	78	nM	Ki	Bioorg Med Chem (2013) 21: 1516-1521 [PMID:22989910]
Carbonic anhydrase 3 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944498] [UniProtKB: Q3SZX4]
ChEMBL	Inhibition of bovine carbonic anhydrase 3 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	4.08	pKi	83400	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6]
ChEMBL	Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay	B	8.37	pKi	4.3	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 1 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	5.62	pKd	2400	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assay	B	5.85	pKd	1400	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by thermal shift assay	B	5.85	pKd	1400	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 1 by thermal shift assay	B	5.85	pKd	1400	nM	Kd	Bioorg Med Chem (2010) 18: 7413-7421 [PMID:20889345]
ChEMBL	Inhibition of human carbonic anhydrase 1 at pH7 and 37 degC by fluorescent thermal shift assay	B	5.85	pKd	1400	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 1 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	5.96	pKd	1100	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human carbonic anhydrase 1 at pH7 and 37 degC by isothermal titration calorimetry	B	6.09	pKd	810	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 1 by isothermal titration calorimetry assay	B	6.11	pKd	780	nM	Kd	Bioorg Med Chem (2010) 18: 7413-7421 [PMID:20889345]
ChEMBL	Inhibition of human carbonic anhydrase 1 at pH7 and 25 degC by stopped-flow kinetic inhibition assay	B	6.54	pKd	290	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as inhibition constant incubated for 1 hr prior to testing by phenol red based stopped-flow CO2 hydration assay	B	3.6	pKi	250000	nM	Ki	Bioorg Med Chem (2022) 67: 116805-116805 [PMID:35635929]
ChEMBL	Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	4.44	pKi	36200	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
ChEMBL	Inhibition of human erythrocytes esterase activity of carbonic anhydrase-1 using 4-nitrophenylacetate as substrate after 3 mins by Lineweaver-Burk plot analysis	B	4.44	pKi	36200	nM	Ki	Bioorg Med Chem (2013) 21: 1379-1385 [PMID:23394864]
ChEMBL	Inhibition of human erythrocyte CA1 esterase activity using 4-nitrophenyl acetate substrate	B	4.44	pKi	36200	nM	Ki	Bioorg Med Chem (2009) 17: 3207-3211 [PMID:19231207]
ChEMBL	Inhibition of human carbonic anhydrase 1 esterase activity using 4-nitrophenylacetate as substrate	B	4.44	pKi	36200	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL	Inhibition of human erythrocytes CA1 using 4-nitrophenylacetate as substrate by esterase assay	B	4.44	pKi	36200	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3261-3263 [PMID:26073005]
ChEMBL	Inhibition of human carbonic anhydrase 1 by Lineweaver-Burke plot analysis	B	5.2	pKi	6300	nM	Ki	Eur J Med Chem (2010) 45: 4769-4773 [PMID:20724038]
ChEMBL	Inhibition of human carbonic anhydrase 1 by Lineweaver-Burke plot	B	5.46	pKi	3500	nM	Ki	Bioorg Med Chem (2009) 17: 3295-3301 [PMID:19362844]
ChEMBL	Inhibition of human carbonic anhydrase 1 using 4-NPA as substrate measured for 3 mins by spectrophotometry	B	5.81	pKi	1532.01	nM	Ki	Bioorg Med Chem Lett (2020) 30: 126874-126874 [PMID:31859159]
ChEMBL	Inhibition of human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2004) 14: 225-229 [PMID:14684332]
ChEMBL	Inhibitory activity against human carbonic anhydrase I.	B	6.05	pKi	900	nM	Ki	J Med Chem (2003) 46: 5471-5477 [PMID:14640555]
ChEMBL	Inhibitory activity against human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5775-5780 [PMID:15501039]
ChEMBL	In vitro inhibitory activity against human carbonic anhydrase I (hCAI)	B	6.05	pKi	900	nM	Ki	J Med Chem (2004) 47: 2796-2804 [PMID:15139757]
ChEMBL	Inhibitory activity against human cloned Carbonic anhydrase I by the CO2 hydration method	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4872-4876 [PMID:16165351]
ChEMBL	Inhibitory activity against Human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2002) 45: 1466-1476 [PMID:11906288]
ChEMBL	Inhibition against human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2004) 14: 231-234 [PMID:14684333]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 6 hrs by Lineweaver-Burk plot analysis	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2515-2520 [PMID:21420862]
ChEMBL	Inhibition of human recombinant carbonic anhydrase I (CA1)	B	6.05	pKi	900	nM	Ki	J Med Chem (2000) 43: 4542-4551 [PMID:11087579]
ChEMBL	Inhibitory activity against human cloned isoenzyme carbonic anhydrase I (hCA I), by esterase method.	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2003) 13: 837-840 [PMID:12617903]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5781-5786 [PMID:15501040]
ChEMBL	Inhibition of human CA1	B	6.05	pKi	900	nM	Ki	J Med Chem (2006) 49: 2743-2749 [PMID:16640335]
ChEMBL	Inhibitory activity against cytosolic human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration assay	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration method	B	6.05	pKi	900	nM	Ki	J Med Chem (2006) 49: 6539-6548 [PMID:17064072]
ChEMBL	Inhibition of cloned isozyme, human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2001) 11: 575-582 [PMID:11229775]
ChEMBL	Inhibitory potency against human cloned Carbonic anhydrase I expressed in Escherichia coli strain BL21	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2005) 15: 367-372 [PMID:15603956]
ChEMBL	Inhibitory effect on human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2002) 45: 312-320 [PMID:11784136]
ChEMBL	Inhibition of human recombinant isozyme CA1 by CO2 hydration method	B	6.05	pKi	900	nM	Ki	J Med Chem (2007) 50: 1651-1657 [PMID:17343373]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2000) 43: 4884-4892 [PMID:11123998]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase I (CA1)	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration stopped-flow assay	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3475-3480 [PMID:18513964]
ChEMBL	Inhibition constant against human (cloned) isozyme (hCA I) by the CO2 hydration method	B	6.05	pKi	900	nM	Ki	J Med Chem (2005) 48: 4834-4841 [PMID:16033263]
ChEMBL	Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem (2009) 17: 553-557 [PMID:19097911]
ChEMBL	Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378]
ChEMBL	Inhibitory activity against human Carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2004) 47: 5224-5229 [PMID:15456265]
ChEMBL	Inhibition of human recombinant carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2003) 46: 2197-2204 [PMID:12747791]
ChEMBL	Inhibitory constant against human Carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325]
ChEMBL	Inhibition of cloned human cytosolic isozyme Carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2004) 47: 1272-1279 [PMID:14971907]
ChEMBL	Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay	B	6.32	pKi	481	nM	Ki	J Med Chem (2009) 52: 4063-4067 [PMID:19438226]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 using 4-nitrophenyl acetate as substrate assessed as inhibition constant by spectrophotometric analysis	B	6.35	pKi	451.8	nM	Ki	Bioorg Med Chem (2023) 77: 117111-117111 [PMID:36463726]
ChEMBL	Binding affinity to carbonic anhydrase 1 (unknown origin) assessed as inhibition constant	B	6.36	pKi	436.2	nM	Ki	Eur J Med Chem (2022) 233: 114242-114242 [PMID:35276424]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometry based esterase assay	B	6.36	pKi	434.55	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of esterase activity of human carbonic anhydrase 2 by Lineweaver-Burke plot analysis	B	6.43	pKi	370	nM	Ki	Bioorg Med Chem (2010) 18: 4468-4474 [PMID:20554206]
ChEMBL	Inhibition of human CA1 using 4-nitrophenylacetate as substrate preincubated for 10 mins by spectrophotometric esterase assay	B	6.47	pKi	342	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.51	pKi	310	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human cloned CA1 after 15 mins by stopped-flow CO2 hydration assay	B	6.51	pKi	310	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration method	B	6.51	pKi	310	nM	Ki	Bioorg Med Chem (2007) 15: 2298-2311 [PMID:17276072]
ChEMBL	Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.51	pKi	310	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human erythrocyte CA1 b using 4-nitrophenyl acetate as substrate by Lineweaver-Burk plot analysis	B	6.54	pKi	289	nM	Ki	Eur J Med Chem (2020) 198: 112392-112392 [PMID:32388113]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant using p-Nitrophenylacetate as substrate by SDS-PAGE analysis	B	6.55	pKi	282.1	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human CA1	B	6.55	pKi	278.8	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of human CA1	B	6.55	pKi	278.76	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of cytosolic carbonic anhydrase 1 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	252.2	nM	Ki	Eur J Med Chem (2013) 66: 372-379 [PMID:23827177]
GtoPdb	-	-	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6 [PMID:15546717]; Bioorg Med Chem Lett (2005) 15: 963-9 [PMID:15686894]; Bioorg Med Chem Lett (2010) 20: 4376-81 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped flow carbon dioxide hydrase assay	B	6.6	pKi	250.2	nM	Ki	J Med Chem (2016) 59: 10692-10704 [PMID:27933963]
ChEMBL	Inhibition of human cloned CA1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 6421-6432 [PMID:19827837]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301]
ChEMBL	Inhibition of human recombinant CA1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5825-5828 [PMID:19751975]
ChEMBL	Inhibition of human CA1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of human recombinant carbonic anhydrase1 after 15 mins by stopped flow carbon dioxide hydrase assay method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2178-2182 [PMID:20211561]
ChEMBL	Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2010) 53: 2913-2926 [PMID:20201556]
ChEMBL	Inhibition of full length human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human carbonic anhydrase 1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3623-3627 [PMID:20478708]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2010) 18: 4873-4878 [PMID:20598552]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of wild type human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) after 15 mins by CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2010) 18: 5498-5503 [PMID:20624682]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2010) 18: 5081-5089 [PMID:20580561]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 243-248 [PMID:21163660]
ChEMBL	Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL	Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 min by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 15 mins by Lineweaver-Burk plot	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of human recombinant alpha-carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2011) 54: 1682-1692 [PMID:21332115]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2521-2526 [PMID:21402476]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay at pH 8.3	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3591-3595 [PMID:21570835]
ChEMBL	Inhibition of human CA1 by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3216-3221 [PMID:21549597]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3170-3173 [PMID:19435663]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2011) 54: 3977-3981 [PMID:21506569]
ChEMBL	Inhibition of human full length cytosolic isoform of carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2975-2979 [PMID:21470859]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 3732-3738 [PMID:21620713]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human recombinant CA1 by CO2 hydration based stopped flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2011) 54: 6905-6918 [PMID:21851094]
ChEMBL	Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration activity by stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5892-5896 [PMID:21852133]
ChEMBL	Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2012) 20: 2392-2404 [PMID:22370338]
ChEMBL	Inhibition of human CA1 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2012) 55: 1721-1730 [PMID:22276570]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	6.6	pKi	250	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL	Inhibition of human recombinant full length CA1-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2012) 55: 3891-3899 [PMID:22443141]
ChEMBL	Inhibition of human CA1 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2012) 22: 5801-5806 [PMID:22901388]
ChEMBL	Inhibition of full length human CA1 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2012) 22: 7142-7145 [PMID:23072866]
ChEMBL	Inhibition of human recombinant wild type CA1 by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 256-260 [PMID:23200251]
ChEMBL	Inhibition of full length human recombinant CA1 cytosolic isoform after 6 hrs by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 293-300 [PMID:23241068]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 1761-1771 [PMID:23391336]
ChEMBL	Inhibition of human CA1 by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 715-719 [PMID:23265898]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-1-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 1386-1391 [PMID:23352754]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 10 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 1451-1464 [PMID:23168081]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase-1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1626-1630 [PMID:23414801]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 1396-1403 [PMID:23290254]
ChEMBL	Inhibition of human carbonic anhydrase-1 cytosolic isoform after 15 mins by Stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 2314-2318 [PMID:23490152]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029]
ChEMBL	Inhibition of recombinant human CA1 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 4691-4700 [PMID:23647428]
ChEMBL	Inhibition of human carbonic anhydrase-1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 2925-2931 [PMID:23623256]
ChEMBL	Inhibition of human recombinant CA1 by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins to 6 hrs by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 5773-5781 [PMID:23815159]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 3949-3957 [PMID:23706268]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 after 6 hrs by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 4502-4510 [PMID:23769167]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 10 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 5228-5232 [PMID:23842519]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 5130-5138 [PMID:23859774]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 5799-5805 [PMID:23910989]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of full length human cytosolic carbonic anhydrase-1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 8512-8520 [PMID:24128000]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6706-6710 [PMID:24210500]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6759-6763 [PMID:24189056]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 9623-9634 [PMID:24200125]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human CA1 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human carbonic anhydrase 1 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 141-147 [PMID:24332658]
ChEMBL	Inhibition of human CA1 cytosolic isoform after 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1127-1132 [PMID:24461298]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 after 6 hrs by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 1522-1528 [PMID:24513186]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 1873-1882 [PMID:24560737]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
ChEMBL	Inhibition of human carbonic anhydrase 1-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 76: 284-290 [PMID:24589484]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 1821-1831 [PMID:24560739]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1-mediated CO2 hydration after 6 hrs by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1256-1260 [PMID:24518190]
ChEMBL	Inhibition of human recombinant cytosolic human carbonic anhydrase-1 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1776-1779 [PMID:24589511]
ChEMBL	Inhibition of human carbonic anhydrase 1-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 2643-2647 [PMID:24713308]
ChEMBL	Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL	Inhibition of human cloned cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 3684-3695 [PMID:24878360]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydrase assay method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 6945-6952 [PMID:25456084]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4006-4010 [PMID:25011913]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2014) 5: 793-796 [PMID:25050167]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2014) 5: 826-830 [PMID:25050173]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 84: 240-246 [PMID:25019479]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase Assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2014) 5: 927-930 [PMID:25147616]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 5185-5189 [PMID:25442309]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2014) 57: 9152-9167 [PMID:25310626]
ChEMBL	Inhibition of human CA-1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2014) 57: 9673-9686 [PMID:25358036]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4389-4396 [PMID:25168745]
ChEMBL	Inhibition of human full length CA1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 6353-6359 [PMID:25438758]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4402-4406 [PMID:25168748]
ChEMBL	Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 87: 186-196 [PMID:25255434]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 5133-5140 [PMID:25194929]
ChEMBL	Inhibition of human CA-1 after 15 mins by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 5883-5890 [PMID:25267005]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 1430-1436 [PMID:25753329]
ChEMBL	Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 1421-1429 [PMID:25757603]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 2368-2376 [PMID:25846066]
ChEMBL	Inhibition of human recombinant CA-1 after 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 1828-1840 [PMID:25766630]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2015) 58: 1494-1501 [PMID:25581127]
ChEMBL	Inhibition of human cytosolic form of carbonic anhydrase-1 assessed as CO2 hydration activity incubated for 15 mins prior to testing by stopped flow method	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2015) 96: 425-435 [PMID:25912674]
ChEMBL	Inhibition of human recombinant carbonic anhdydrase-1 expressed in Escherichia coli pre-incubated for 6 hrs by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2015) 58: 3975-3983 [PMID:25875209]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of human carbonic anhydrase-1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay based Lineweaver-Burk plot method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 3674-3680 [PMID:25921266]
ChEMBL	Inhibition of human CA1 after 15 mins by stopped-flow/Co2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 4405-4409 [PMID:26145820]
ChEMBL	Inhibition of human carbonic anhydrase 1 by by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli preincubated for 15 mins by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 4649-4659 [PMID:26088336]
ChEMBL	Inhibition of human carbonic anhydrase-1 by CO2 hydration reaction based colorimetric stopped-flow method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 4831-4838 [PMID:26068018]
ChEMBL	Inhibition of human carbonic anhydrase-1 incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3208-3212 [PMID:26105196]
ChEMBL	Inhibition of human recombinant CA1 expressed in Escherichia coli by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2015) 58: 6630-6638 [PMID:26203869]
ChEMBL	Inhibition of human carbonic anhydrase-1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3281-3284 [PMID:26073006]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 5619-5625 [PMID:26233796]
ChEMBL	Inhibition of human carbonic anhydrase-1 incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
ChEMBL	Inhibition of human carbonic anhydrase-1 by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3550-3555 [PMID:26174556]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3850-3853 [PMID:26233435]
ChEMBL	Inhibition of full length human carbonic anhydrase-1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2015) 6: 819-821 [PMID:26191373]
ChEMBL	Inhibition of carbonic anhydrase-1 (unknown origin)	B	6.6	pKi	250	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 expressed in Escherichia coli incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 6573-6580 [PMID:26422787]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 6 hrs by stopped flow carbon-di-oxide hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 6955-6966 [PMID:26432607]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 7219-7225 [PMID:26498393]
ChEMBL	Inhibition of human carbonic anhydrase-1 assessed as CO2 hydration activity by stopped-flow method	B	6.6	pKi	250	nM	Ki	J Med Chem (2015) 58: 8564-8572 [PMID:26497049]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5636-5641 [PMID:26520662]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli preincubated for 6 hrs by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2015) 103: 583-593 [PMID:26408817]
ChEMBL	Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863]
ChEMBL	Inhibition of human carbonic anhydrase-1 preincubated for 15 mins by stopped flow CO2 dehydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 20-25 [PMID:26678172]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 921-927 [PMID:26796953]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 894-901 [PMID:26795114]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 982-988 [PMID:26803577]
ChEMBL	Inhibition of human carbonic anhydrase-1 using p-nitrophenyl acetate as substrate by esterase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1337-1341 [PMID:26804228]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 1095-1105 [PMID:26810710]
ChEMBL	Inhibition of human carbonic anhydrase 1 for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 976-981 [PMID:26810836]
ChEMBL	Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by CO2 hydration-based stopped flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2016) 59: 721-732 [PMID:26741028]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 1402-1407 [PMID:26875933]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1253-1259 [PMID:26832216]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow carbon dioxide hydrase assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2016) 110: 259-266 [PMID:26840366]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 1648-1652 [PMID:26951893]
ChEMBL	Inhibition of human carbonic anhydrase 1 using saturated CO2 as substrate incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 2882-2886 [PMID:27137360]
ChEMBL	Inhibition of human recombinant CA1 preincubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 3043-3051 [PMID:27234893]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 min to 72 hrs by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 2907-2913 [PMID:27166574]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 3413-3417 [PMID:27283786]
ChEMBL	Inhibition of human recombinant CA1 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 3548-3555 [PMID:27298005]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 3643-3648 [PMID:27316543]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2016) 59: 5077-5088 [PMID:27144971]
ChEMBL	Inhibition of human carbonic anhydrase-1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 4406-4409 [PMID:27469982]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 4100-4107 [PMID:27396930]
ChEMBL	Inhibition of human full length carbonic anhydrase 1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 5867-5870 [PMID:27884694]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2017) 27: 86-89 [PMID:27876475]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-1 preincubated for 6 hrs by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 677-683 [PMID:27939347]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 10 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 857-863 [PMID:28024887]
ChEMBL	Inhibition of human erythrocyte carbonic anhydrase 1 preincubated for 15 mins prior to testing by bromothymol blue-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 1260-1265 [PMID:28057408]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-1 using CO2 as substrate preincubated for 10 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 539-544 [PMID:27919611]
ChEMBL	Inhibition of recombinant human erythrocyte cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 1286-1293 [PMID:28065499]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins by stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 1456-1464 [PMID:28111158]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 1 after 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2017) 127: 691-702 [PMID:27823879]
ChEMBL	Inhibition of recombinant human CA1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2017) 60: 1159-1170 [PMID:28075587]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2017) 127: 521-530 [PMID:28109946]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 assessed as reduction in enzyme-catalyzed hydration activity using CO2 as substrate preincubated for 15 mins followed substrate addition measured after 10 to 100 sec by phenol red dye based stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 1914-1925 [PMID:28237553]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as inhibition of CO2 hydration incubated for 15 mins prior to testing by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2010-2015 [PMID:28238511]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 10 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 1666-1671 [PMID:28161252]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 1 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2210-2217 [PMID:28256371]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2017) 60: 2456-2469 [PMID:28253618]
ChEMBL	Inhibition of recombinant human Carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2017) 60: 3154-3164 [PMID:28272885]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2577-2582 [PMID:28343756]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2569-2576 [PMID:28347633]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 10 mins measured for 5 to 10 secs by stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 3583-3589 [PMID:28416101]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2782-2788 [PMID:28389112]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 1 pretreated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2518-2523 [PMID:28302505]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 10 mins by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 3093-3097 [PMID:28400084]
ChEMBL	Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 3567-3573 [PMID:28522267]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2524-2529 [PMID:28318894]
ChEMBL	Inhibition of human CA1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of human CA1 incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 4800-4804 [PMID:28754318]
ChEMBL	Inhibition of human CA1 pre-incubated for 10 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 5373-5379 [PMID:28789908]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-1 preincubated for 10 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 5726-5732 [PMID:28887000]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration pretreated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 792-796 [PMID:28835790]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 1105-1109 [PMID:29057059]
ChEMBL	Inhibition of human carbonic anhydrase-1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 1194-1198 [PMID:29152053]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 1213-1217 [PMID:29259736]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 1314-1319 [PMID:29259754]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2018) 61: 5380-5394 [PMID:29851481]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 15 mins by stopped flow carbon dioxide hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2018) 9: 462-467 [PMID:29795760]
ChEMBL	Inhibition of recombinant human cytosolic CA1 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2018) 61: 5765-5770 [PMID:29912561]
ChEMBL	Binding affinity to human carbonic anhydrase 1 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2018) 9: 725-729 [PMID:30034608]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 151: 363-375 [PMID:29635168]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 152: 1-9 [PMID:29684705]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 154: 210-219 [PMID:29803994]
ChEMBL	Binding affinity to human carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 155: 545-551 [PMID:29909339]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 incubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2018) 61: 4961-4977 [PMID:29746127]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2017) 139: 250-262 [PMID:28802125]
ChEMBL	Inhibition of recombinant human full-length carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 941-946 [PMID:28947941]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 963-968 [PMID:28947945]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated 15 mins prior to testing by CO2 hydration based stopped-flow assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2018) 9: 947-951 [PMID:30258546]
ChEMBL	Inhibition of cytosolic human carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 150: 678-686 [PMID:29571155]
ChEMBL	Inhibition of human CA1 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2018) 61: 6328-6338 [PMID:29962205]
ChEMBL	Inhibition of recombinant human CA1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of human CA1 by Lineweaver-Burk plot analysis	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2018) 9: 1045-1050 [PMID:30344915]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 assessed as CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye-based stopped-flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 156: 430-443 [PMID:30015076]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 157: 28-36 [PMID:30071407]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 157: 1214-1222 [PMID:30193219]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as reduction in CO2 hydration incubated for 1 hr by phenol red staining-based stopped flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 183: 111698-111698 [PMID:31539777]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 10 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 183: 111702-111702 [PMID:31542715]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 184: 111768-111768 [PMID:31629164]
ChEMBL	Inhibition of recombinant full length human carbonic anhydrase-1 assessed as reduction in CO2 hydration after 15 mins by phenol red dye based stopped flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 163: 443-452 [PMID:30530195]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2019) 62: 4174-4192 [PMID:30925064]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2020) 63: 2470-2488 [PMID:31972093]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2019) 62: 7233-7249 [PMID:31287314]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 181: 111565-111565 [PMID:31387062]
ChEMBL	Inhibition of recombinant human CA1 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 181: 111573-111573 [PMID:31394463]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 181: 111586-111586 [PMID:31401537]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibitory constant incubated for 15 mins by phenol red dye based stopped flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 182: 111638-111638 [PMID:31472471]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 182: 111642-111642 [PMID:31476557]
ChEMBL	Inhibition of recombinant human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 182: 111600-111600 [PMID:31419777]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins by phenol red staining-based stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2019) 27: 115086-115086 [PMID:31515057]
ChEMBL	Inhibition of recombinant human carbonic anhydrase1 preincubated for 10 mins followed by CO2 solution addition by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2019) 27: 115090-115090 [PMID:31515058]
ChEMBL	Inhibition of recombinant human CA1 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 185: 111811-111811 [PMID:31693947]
ChEMBL	Inhibition of full length human CA 1	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 168: 301-314 [PMID:30826507]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibitory constant preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 175: 40-48 [PMID:31071549]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2019) 27: 1588-1594 [PMID:30846402]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as reduction in CO2 hydration after 15 mins by phenol red staining-based stopped flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 164: 92-105 [PMID:30594030]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2016) 59: 5857-5867 [PMID:27253845]
ChEMBL	Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 3892-3895 [PMID:27423482]
ChEMBL	Binding affinity to human recombinant CA1 assessed as inhibition constant incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2023) 66: 14824-14842 [PMID:37902628]
ChEMBL	Compound was evaluated for inhibition against human carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 217-223 [PMID:14684331]
ChEMBL	Inhibition constant determined against human cloned carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	J Med Chem (2003) 46: 2187-2196 [PMID:12747790]
ChEMBL	Inhibitory activity against human carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 869-873 [PMID:15012984]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase I (hCA I)	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2003) 13: 841-845 [PMID:12617904]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase isozyme I by esterase assay method.	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL	Inhibition constant evaluated for the inhibition of human CA I (Carbonic anhydrase I)	B	6.6	pKi	250	nM	Ki	J Med Chem (2004) 47: 2337-2347 [PMID:15084132]
ChEMBL	Inhibitory activity against Carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	J Med Chem (2005) 48: 2121-2125 [PMID:15771455]
ChEMBL	Inhibitory constant against cytosolic human Carbonic anhydrase I using CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibitory activity against human carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853]
ChEMBL	Ki value against carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Ki value against human carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Ki value against human carbonic anhydrase I (hCA I)	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894]
ChEMBL	Inhibitory activity against human carbonic anhydrase I (hCAI)	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibitory activity against human carbonic anhydrase I expressed in Escherichia coli BL21	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239]
ChEMBL	Inhibitory activity against human carbonic anhydrase I at 0.09 uM	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibitory constant against human Carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091]
ChEMBL	Inhibition constant against human recombinant carbonic anhydrase I	F	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3302-3306 [PMID:15908201]
ChEMBL	Inhibitory constant against human Carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2347-2352 [PMID:15837323]
ChEMBL	Inhibition constant against human carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against human Carbonic anhydrase I (hCA I)	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibition of recombinant human cytosolic isozyme CA I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 5192-5196 [PMID:16203142]
ChEMBL	Inhibitory activity against cloned human CA1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL	Inhibition of human recombinant CA1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2006) 49: 5544-5551 [PMID:16942027]
ChEMBL	Inhibition of human cloned CA1 by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human recombinant cytosolic isozyme CA I by stopped-flow CO2 hydrase method	B	6.6	pKi	250	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human recombinant CA1 after 15 mins by CO2 hydration stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2007) 17: 2685-2691 [PMID:17376683]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760]
ChEMBL	Inhibition of human cloned carbonic anhydrase1 by CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2007) 15: 6975-6984 [PMID:17822907]
ChEMBL	Inhibition of human recombinant CA 1 assessed as CO2 hydration by stopped flow kinetic assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2007) 15: 7229-7236 [PMID:17826101]
ChEMBL	Inhibition of human carbonic anhydrase 1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant CA1 by CO2 hydration stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2008) 51: 1945-1953 [PMID:18307288]
ChEMBL	Inhibition of human full length carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3593-3596 [PMID:18501600]
ChEMBL	Inhibition of human recombinant full length CA1 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human carbonic anhydrase 1 measured by CO2 hydration reaction assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 650-653 [PMID:19121582]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2008) 18: 6332-6335 [PMID:18990571]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL	Inhibition of human cloned CA1 by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2008) 51: 7968-7979 [PMID:19053764]
ChEMBL	Inhibition of human erythrocytes carbonic anhydrase 1 by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 4853-4859 [PMID:19580287]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2642-2645 [PMID:19375309]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2009) 17: 4894-4899 [PMID:19539481]
ChEMBL	Inhibition of human full length cytosolic carbonic anhydrase 1 after 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human CA1	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of human CA1	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant	B	6.6	pKi	250	nM	Ki	RSC Med Chem (2023) 14: 144-153 [PMID:36760748]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2023) 66: 1616-1633 [PMID:36626645]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 1 assessed as inhibition constant incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2023) 66: 10010-10026 [PMID:37436184]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2024) 67: 3018-3038 [PMID:38301036]
ChEMBL	Inhibition of human carbonic anhydrase I assessed as inhibition constant incubated for 15 min by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2024) 15: 470-477 [PMID:38628786]
ChEMBL	Inhibition of recombinant human CA1 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2023) 66: 5703-5718 [PMID:37022308]
ChEMBL	Inhibition of recombinant human carbonic anhydrase I assessed as inhibition constant incubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2023) 66: 8118-8129 [PMID:37283561]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2023) 66: 10558-10578 [PMID:37501287]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant preincubated for 15 mins and measured for 10 to 100 sec by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 243: 114793-114793 [PMID:36201858]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant incubated for 6 hrs by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2023) 246: 115011-115011 [PMID:36516582]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant incubated for 1 hr prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2023) 14: 1067-1072 [PMID:37583824]
ChEMBL	Inhibition of human CA I assessed as inhibition constant by stopped-flow CO2 hydrase assay method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2023) 95: 129479-129479 [PMID:37704010]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant preincubated for 15 mins and measured by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2023) 94: 117467-117467 [PMID:37722299]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant by stopped flow kinetic assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2023) 250: 115180-115180 [PMID:36796297]
ChEMBL	Inhibitory activity against human carbonic anhydrase I (hCA I) by using esterase assay method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 3757-3762 [PMID:15203157]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of human CA1 pre-incubated for 15 mins by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2020) 63: 7392-7409 [PMID:32463228]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 10 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2020) 11: 633-637 [PMID:32435363]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2020) 11: 852-856 [PMID:32435395]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2020) 11: 1022-1027 [PMID:32435420]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by stopped-flow CO2 hydration kinetic assay based Cheng-Prusoff equation analysis	B	6.6	pKi	250	nM	Ki	J Med Chem (2020) 63: 7422-7444 [PMID:32519851]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibitory constant incubated for 6 hrs by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2020) 28: 115496-115496 [PMID:32327349]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2020) 28: 115329-115329 [PMID:32007388]
ChEMBL	Inhibition of recombinant human CA1 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2020) 63: 13064-13075 [PMID:33085484]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2018) 61: 3151-3165 [PMID:29566486]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 188: 112021-112021 [PMID:31901743]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 200: 112300-112300 [PMID:32460112]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 200: 112449-112449 [PMID:32485534]
ChEMBL	Inhibition of human CA1 incubated for 15 mins by stopped- flow CO2 hydrase assay method	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 201: 112478-112478 [PMID:32659606]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 207: 112745-112745 [PMID:32877804]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 212: 113035-113035 [PMID:33303238]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2021) 37: 127856-127856 [PMID:33609663]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as inhibition constant preincubated with enzyme for 10 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2020) 28: 115586-115586 [PMID:32631564]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 209: 112875-112875 [PMID:33059188]
ChEMBL	Inhibition of human CA1 incubated for 15 mins by stopped-flow CO2 hydration kinetic assay based Cheng-Prusoff equation analysis	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 214: 113260-113260 [PMID:33581552]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 190: 112112-112112 [PMID:32044580]
ChEMBL	Inhibition of human CA1 by stopped-flow carbon dioxide hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 200: 112439-112439 [PMID:32485532]
ChEMBL	Inhibition of human CA1 measured by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2021) 48: 128249-128249 [PMID:34237441]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2021) 49: 128309-128309 [PMID:34371130]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 218: 113360-113360 [PMID:33773285]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 218: 113352-113352 [PMID:33774343]
ChEMBL	Inhibition of recombinant human CA 1 preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2021) 45: 128147-128147 [PMID:34052322]
ChEMBL	Inhibition of recombinant human CA1 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2021) 44: 116279-116279 [PMID:34216985]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 210: 112994-112994 [PMID:33234343]
ChEMBL	Inhibition of human CA1 by stopped- flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 216: 113283-113283 [PMID:33667848]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 217: 113351-113351 [PMID:33744685]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2021) 64: 3100-3114 [PMID:33721499]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 222: 113589-113589 [PMID:34147910]
ChEMBL	Inhibition of recombinant human CA1 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 220: 113490-113490 [PMID:33975138]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 225: 113793-113793 [PMID:34507012]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 221: 113486-113486 [PMID:33965860]
ChEMBL	Inhibition of human CA1 measured after 15 mins by stopped flow carbon dioxide anhydrase assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 225: 113800-113800 [PMID:34482273]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2021) 64: 11432-11444 [PMID:34283610]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 228: 114004-114004 [PMID:34847409]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 228: 114008-114008 [PMID:34871842]
ChEMBL	Inhibition of human CA1 incubated for 15 mins prior to testing by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 228: 114026-114026 [PMID:34920169]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2022) 65: 824-837 [PMID:34958217]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 228: 113997-113997 [PMID:34902732]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Binding affinity to human recombinant CA1 assessed as inhibition constant incubated for 10 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2022) 65: 13143-13157 [PMID:36121705]
ChEMBL	Inhibition of human recombinant CA1 assessed as inhibition constant pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2022) 65: 13946-13966 [PMID:36201615]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 238: 114412-114412 [PMID:35551035]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped flow CO2 assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2022) 70: 128809-128809 [PMID:35605838]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2022) 59: 128581-128581 [PMID:35066141]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 assessed as inhibition constant incubated for 10 mins by phenol red dye based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 234: 114247-114247 [PMID:35305463]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as inhibition constant preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 227: 113956-113956 [PMID:34731762]
ChEMBL	Inhibition of recombinant human CA 1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 232: 114190-114190 [PMID:35182815]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 10 mins and measured by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2022) 65: 14655-14672 [PMID:36269278]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2020) 28: 115813-115813 [PMID:33069128]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2023) 14: 810-819 [PMID:37312840]
ChEMBL	Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate by Lineweaver-Burk plot analysis	B	6.69	pKi	204.03	nM	Ki	Bioorg Med Chem (2016) 24: 2318-2329 [PMID:27068142]
ChEMBL	Inhibitory activity against human carbonic anhydrase I (hCA I)	B	6.7	pKi	200	nM	Ki	Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846]
ChEMBL	Inhibition of human carbonic anhydrase 1 by Stopped-Flow CO2 Hydrase assay	B	6.7	pKi	200	nM	Ki	J Med Chem (2016) 59: 462-473 [PMID:26688270]
ChEMBL	Inhibition of human CA-1 using p-nitro-phenylacetate as substrate by Lineweaver-Burk plot analysis	B	6.73	pKi	184.3	nM	Ki	Bioorg Med Chem (2015) 23: 2598-2605 [PMID:25863492]
ChEMBL	Inhibition of human CA1 using para-nitrophenylacetate as substrate measured over 3 mins by UV-vis spectrophotometric method	B	6.73	pKi	184.3	nM	Ki	J Med Chem (2015) 58: 640-650 [PMID:25432060]
ChEMBL	Inhibition of human CA1 by stopped-flow assay	B	6.74	pKi	182.09	nM	Ki	Bioorg Med Chem (2021) 39: 116140-116140 [PMID:33905966]
ChEMBL	Inhibition of human CA1	B	6.74	pKi	182	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant by SDS-PAGE analysis	B	6.78	pKi	164.7	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human CA1 by UV spectrophotometric analysis	B	6.78	pKi	164.7	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of esterase activity of carbonic anhydrase 1 in human erythrocytes using PNF as substrate by spectrophotometer analysis	B	7.21	pKi	61.1	nM	Ki	Bioorg Med Chem (2015) 23: 3592-3602 [PMID:25921269]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant by esterase activity assay	B	7.29	pKi	51.17	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Binding affinity to human recombinant CA1 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 2867-2874 [PMID:24746465]
ChEMBL	Inhibition of carbonic anhydrase-1 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by bromine thymol blue indicator based assay	B	8.05	pKi	8.89	nM	Ki	Bioorg Med Chem (2017) 25: 3547-3554 [PMID:28511907]
ChEMBL	Inhibition of human CAH1 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	8.36	pKi	4.4	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysis	B	9.13	pKi	0.75	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human carbonic anhydrase-1 preincubated for 15 mins by stopped flow CO2 dehydration method	B	9.6	pKi	0.25	nM	Ki	Bioorg Med Chem (2016) 24: 104-112 [PMID:26682703]
ChEMBL	Inhibition of esterase-activity of CA1 from human erythrocytes by spectrophotometry	B	5.21	pIC50	6100	nM	IC50	Bioorg Med Chem (2010) 18: 930-938 [PMID:20006931]
ChEMBL	Inhibition of CA1 from human erythrocytes by Lineweaver-Burke analysis	B	5.28	pIC50	5200	nM	IC50	Bioorg Med Chem (2010) 18: 930-938 [PMID:20006931]
ChEMBL	Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometry	B	5.42	pIC50	3800	nM	IC50	Eur J Med Chem (2010) 45: 4769-4773 [PMID:20724038]
ChEMBL	Inhibition of CO2-hydratase activity of human carbonic anhydrase 1 by CO2 hydration method	B	5.43	pIC50	3750	nM	IC50	Bioorg Med Chem (2009) 17: 3295-3301 [PMID:19362844]
ChEMBL	Inhibition of hydratase-activity of CA1 from human erythrocytes by CO2-hydration method	B	5.44	pIC50	3600	nM	IC50	Bioorg Med Chem (2010) 18: 930-938 [PMID:20006931]
ChEMBL	Inhibition of human carbonic anhydrase 1 hydratase activity by spectrophotometry	B	5.51	pIC50	3100	nM	IC50	Eur J Med Chem (2010) 45: 4769-4773 [PMID:20724038]
ChEMBL	Inhibition of esterase activity of human carbonic anhydrase 1 by CO2 hydration method	B	5.54	pIC50	2900	nM	IC50	Bioorg Med Chem (2009) 17: 3295-3301 [PMID:19362844]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as 4-nitrophenyl acetate hydrolysis	B	5.92	pIC50	1210	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2267-2271 [PMID:18353640]
ChEMBL	Inhibition of carbonic anhydrase 1 (unknown origin)	B	6.05	pIC50	900	nM	IC50	Bioorg Med Chem Lett (2022) 57: 128520-128520 [PMID:34965467]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	6.29	pIC50	509.6	nM	IC50	Eur J Med Chem (2013) 62: 597-604 [PMID:23429054]
ChEMBL	Inhibition of human erythrocyte CA1 using 4-nitrophenyl acetate as substrate by spectrophotometry	B	6.44	pIC50	361	nM	IC50	Eur J Med Chem (2020) 198: 112392-112392 [PMID:32388113]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as 4-nitrophenyl phosphate hydrolysis	B	6.48	pIC50	330	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2267-2271 [PMID:18353640]
ChEMBL	Inhibition of human CA-1 using p-nitro-phenylacetate as substrate after 3 mins by UV-Vis spectrophotometry	B	6.5	pIC50	315.5	nM	IC50	Bioorg Med Chem (2015) 23: 2598-2605 [PMID:25863492]
ChEMBL	Inhibition of recombinant human CA1 using 4-nitrophenylacetate as substrate by esterase assay	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2021) 53: 128420-128420 [PMID:34728369]
ChEMBL	Inhibition of human CA1 using 4-nitrophenylacetate as substrate incubated for 10 mins prior to testing by spectrophotometry based esterase assay	B	6.52	pIC50	300	nM	IC50	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2021) 51: 128291-128291 [PMID:34324968]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 pretreated for 15 mins by stopped flow CO2 hydrase assay	B	6.52	pIC50	299	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2617-2620 [PMID:24813742]
ChEMBL	Inhibition of CA-1 (unknown origin) after 15 mins by CO2 hydration assay	B	6.53	pIC50	295	nM	IC50	Bioorg Med Chem Lett (2014) 24: 3422-3425 [PMID:24948563]
ChEMBL	Inhibitory activity against human carbonic anhydrase I was determined	B	6.6	pIC50	250	nM	IC50	J Med Chem (2004) 47: 550-557 [PMID:14736236]
ChEMBL	Inhibitory activity of compound against human carbonic anhydrase I	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem Lett (2004) 14: 337-341 [PMID:14698154]
ChEMBL	Inhibition of human recombinant CA1 incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pIC50	250	nM	IC50	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate by spectrophotometric analysis	B	6.68	pIC50	210.11	nM	IC50	Bioorg Med Chem (2016) 24: 2318-2329 [PMID:27068142]
ChEMBL	Inhibition of human CA1 by stopped-flow assay	B	6.71	pIC50	197.1	nM	IC50	Bioorg Med Chem (2021) 39: 116140-116140 [PMID:33905966]
ChEMBL	Inhibition of human CA1	B	6.71	pIC50	197	nM	IC50	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of full length carbonic anhydrase-1 in human erythrocytes	B	6.79	pIC50	161.11	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3496-3499 [PMID:23664215]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.32	pIC50	48	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1941-1943 [PMID:24650641]
ChEMBL	Inhibition of human CA1 using 4-nitrophenylacetate as substrate by spectrophotometrical analysis	B	7.5	pIC50	31.8	nM	IC50	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of carbonic anhydrase-1 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by bromine thymol blue indicator based assay	B	8.24	pIC50	5.8	nM	IC50	Bioorg Med Chem (2017) 25: 3547-3554 [PMID:28511907]
ChEMBL	Inhibition of human erythrocyte carbonic anhydrase-1	B	8.24	pIC50	5.8	nM	IC50	Eur J Med Chem (2017) 125: 190-196 [PMID:27657811]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 2 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	7.34	pKd	46	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human carbonic anhydrase 2 at pH7 and 37 degC by isothermal titration calorimetry	B	7.34	pKd	46	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of human carbonic anhydrase 2 at pH7 and 37 degC by fluorescent thermal shift assay	B	7.42	pKd	38	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to human recombinant CA2 at 37 degC and pH 7.0 by thermal shift assay	B	7.42	pKd	38	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 2 by isothermal titration calorimetry assay	B	7.74	pKd	18	nM	Kd	Bioorg Med Chem (2010) 18: 7413-7421 [PMID:20889345]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 2 by thermal shift assay	B	7.77	pKd	17	nM	Kd	Bioorg Med Chem (2010) 18: 7413-7421 [PMID:20889345]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 2 by thermal shift assay	B	7.77	pKd	17	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Binding affinity to human full length His-tagged CA2 (1 to 260 residues) expressed in Escherichia coli BL21(DE3) assessed as thermodynamic equilibrium constant at pH 7 by SPR assay	B	7.82	pKd	15	nM	Kd	J Med Chem (2018) 61: 2292-2302 [PMID:29466001]
ChEMBL	Inhibition of human carbonic anhydrase 2 at pH7 and 25 degC by stopped-flow kinetic inhibition assay	B	8	pKd	10	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 2 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	8.01	pKd	9.8	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Dissociation constant against human Carbonic anhydrase II (HCA II)	B	8.17	pKd	6.8	nM	Kd	J Med Chem (1994) 37: 2100-2105 [PMID:8027991]
ChEMBL	Binding affinity to human full length His-tagged CA2 (1 to 260 residues) expressed in Escherichia coli BL21(DE3) assessed as intrinsic thermodynamic equilibrium constant at pH 7 by SPR assay	B	8.59	pKd	2.6	nM	Kd	J Med Chem (2018) 61: 2292-2302 [PMID:29466001]
ChEMBL	Inhibition of carbonic anhydrase 2 assessed as inhibition of carbon dioxide hydration	B	1.08	pKi	1.08	-	logKi	Eur J Med Chem (2009) 44: 3439-3444 [PMID:19303173]
ChEMBL	Inhibition of esterase activity of human carbonic anhydrase 1 by Lineweaver-Burke plot analysis	B	4.44	pKi	36200	nM	Ki	Bioorg Med Chem (2010) 18: 4468-4474 [PMID:20554206]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition constant incubated for 1 hr prior to testing by phenol red based stopped-flow CO2 hydration assay	B	4.9	pKi	12500	nM	Ki	Bioorg Med Chem (2022) 67: 116805-116805 [PMID:35635929]
ChEMBL	Inhibitory activity against human carbonic anhydrase II at 0.01 uM	B	4.92	pKi	12000	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibition of human erythrocytes esterase activity of carbonic anhydrase-2 using 4-nitrophenylacetate as substrate after 3 mins by Lineweaver-Burk plot analysis	B	5.43	pKi	3700	nM	Ki	Bioorg Med Chem (2013) 21: 1379-1385 [PMID:23394864]
ChEMBL	Inhibition of human carbonic anhydrase 2 by Lineweaver-Burke plot analysis	B	5.48	pKi	3300	nM	Ki	Eur J Med Chem (2010) 45: 4769-4773 [PMID:20724038]
ChEMBL	Inhibition of human carbonic anhydrase 2 by Lineweaver-Burke plot	B	5.7	pKi	2000	nM	Ki	Bioorg Med Chem (2009) 17: 3295-3301 [PMID:19362844]
ChEMBL	Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	6.43	pKi	370	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
ChEMBL	Inhibition of human erythrocyte CA2 esterase activity using 4-nitrophenyl acetate substrate	B	6.43	pKi	370	nM	Ki	Bioorg Med Chem (2009) 17: 3207-3211 [PMID:19231207]
ChEMBL	Inhibition of human carbonic anhydrase 2 esterase activity using 4-nitrophenylacetate as substrate	B	6.43	pKi	370	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL	Inhibition of human erythrocytes CA2 using 4-nitrophenylacetate as substrate by esterase assay	B	6.43	pKi	370	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3261-3263 [PMID:26073005]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 using 4-nitrophenyl acetate as substrate assessed as inhibition constant by spectrophotometric analysis	B	6.49	pKi	327.3	nM	Ki	Bioorg Med Chem (2023) 77: 117111-117111 [PMID:36463726]
ChEMBL	Inhibition of human CA2	B	6.53	pKi	293.43	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of human CA2	B	6.53	pKi	293.4	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of human carbonic anhydrase 2-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 2867-2874 [PMID:24746465]
ChEMBL	Inhibition of esterase activity of carbonic anhydrase 2 in human erythrocytes using PNF as substrate by spectrophotometer analysis	B	6.73	pKi	184.3	nM	Ki	Bioorg Med Chem (2015) 23: 3592-3602 [PMID:25921269]
ChEMBL	Inhibition of human CA2 using 4-nitrophenylacetate as substrate preincubated for 10 mins by spectrophotometric esterase assay	B	6.8	pKi	159	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human erythrocyte CA2 using 4-nitrophenyl acetate as substrate by Lineweaver-Burk plot analysis	B	6.87	pKi	135	nM	Ki	Eur J Med Chem (2020) 198: 112392-112392 [PMID:32388113]
ChEMBL	Inhibition of human CA2 by UV spectrophotometric analysis	B	6.88	pKi	132.6	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Binding affinity to human CA2 assessed as inhibition constant by SDS-PAGE analysis	B	6.88	pKi	132.6	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of recombinant human CA2 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay	B	6.9	pKi	125	nM	Ki	J Med Chem (2021) 64: 3100-3114 [PMID:33721499]
ChEMBL	Inhibition of human recombinant CA2 by stopped flow CO2 hydration assay	B	6.98	pKi	104	nM	Ki	J Med Chem (2009) 52: 4063-4067 [PMID:19438226]
ChEMBL	Inhibition of human CA2 by stopped-flow assay	B	6.98	pKi	103.6	nM	Ki	Bioorg Med Chem (2021) 39: 116140-116140 [PMID:33905966]
ChEMBL	Binding affinity to human CA2 assessed as inhibition constant using p-Nitrophenylacetate as substrate by SDS-PAGE analysis	B	6.98	pKi	103.6	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human CA2	B	6.99	pKi	103	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Binding affinity to human CA2 assessed as inhibition constant by Lineweaver-Burk plot analysis	B	6.99	pKi	103	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Binding affinity to carbonic anhydrase 2 (unknown origin) assessed as inhibition constant	B	7.03	pKi	93.5	nM	Ki	Eur J Med Chem (2022) 233: 114242-114242 [PMID:35276424]
ChEMBL	Inhibition of human CA2 using para-nitrophenylacetate as substrate measured over 3 mins by UV-vis spectrophotometric method	B	7.21	pKi	61.1	nM	Ki	J Med Chem (2015) 58: 640-650 [PMID:25432060]
ChEMBL	Inhibition of human CA-2 using p-nitro-phenylacetate as substrate by Lineweaver-Burk plot analysis	B	7.21	pKi	61.1	nM	Ki	Bioorg Med Chem (2015) 23: 2598-2605 [PMID:25863492]
ChEMBL	Inhibition of human wild type carbonic anhydrase 2 Asn67Ile mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	B	7.27	pKi	54.1	nM	Ki	Bioorg Med Chem (2012) 20: 2208-2213 [PMID:22386980]
ChEMBL	Binding affinity to human CA2 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometry based esterase assay	B	7.32	pKi	47.6	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay	B	7.4	pKi	40	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate by Lineweaver-Burk plot analysis	B	7.48	pKi	32.91	nM	Ki	Bioorg Med Chem (2016) 24: 2318-2329 [PMID:27068142]
ChEMBL	Binding affinity to human CA2 assessed as inhibition constant by esterase activity assay	B	7.49	pKi	32.15	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human wild type carbonic anhydrase 2 Gln92Val mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	B	7.53	pKi	29.7	nM	Ki	Bioorg Med Chem (2012) 20: 2208-2213 [PMID:22386980]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2020) 63: 3317-3326 [PMID:32031797]
ChEMBL	Inhibition of human CA2	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 4560-4565 [PMID:28728897]
ChEMBL	Inhibition of recombinant human CA2 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2019) 181: 111573-111573 [PMID:31394463]
ChEMBL	Dissociation constant against Carbonic anhydrase II was reported in experiment 2	B	7.66	pKi	22	nM	Ki	J Med Chem (2002) 45: 3588-3602 [PMID:12166932]
ChEMBL	The equilibrium dissociation constant of the inhibitor-enzyme complex of human carbonic anhydrase	B	7.66	pKi	22	nM	Ki	J Med Chem (1989) 32: 2510-2513 [PMID:2585439]
ChEMBL	Inhibitory constant value for Carbonic anhydrase II in human determined in esterase assay	B	7.74	pKi	18	nM	Ki	J Med Chem (2005) 48: 1941-1947 [PMID:15771438]
ChEMBL	Inhibition of human carbonic anhydrase 2 using 4-NPA as substrate measured for 3 mins by spectrophotometry	B	7.87	pKi	13.52	nM	Ki	Bioorg Med Chem Lett (2020) 30: 126874-126874 [PMID:31859159]
ChEMBL	Inhibition of recombinant human CA2 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.89	pKi	12.8	nM	Ki	Eur J Med Chem (2021) 225: 113793-113793 [PMID:34507012]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.89	pKi	12.8	nM	Ki	Eur J Med Chem (2021) 212: 113035-113035 [PMID:33303238]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as inhibitory constant incubated for 15 mins by phenol red dye based stopped flow assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2019) 182: 111638-111638 [PMID:31472471]
ChEMBL	Inhibition of human CA2 measured after 15 mins by stopped flow carbon dioxide anhydrase assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2021) 225: 113800-113800 [PMID:34482273]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	7.9	pKi	12.5	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of recombinant human CA2 pre-incubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2021) 218: 113352-113352 [PMID:33774343]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2022) 228: 114008-114008 [PMID:34871842]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2020) 188: 112021-112021 [PMID:31901743]
ChEMBL	Inhibition of recombinant human CA2 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	Bioorg Med Chem (2021) 44: 116279-116279 [PMID:34216985]
ChEMBL	Binding affinity to human CA2 assessed as inhibition constant by stopped flow kinetic assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2023) 250: 115180-115180 [PMID:36796297]
ChEMBL	Inhibition of recombinant human CA2 pre-incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	J Med Chem (2022) 65: 13143-13157 [PMID:36121705]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration incubated for 1 hr by phenol red staining-based stopped flow assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2019) 183: 111698-111698 [PMID:31539777]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2020) 200: 112449-112449 [PMID:32485534]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as inhibition constant by stopped-flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	ACS Med Chem Lett (2023) 14: 103-109 [PMID:36655133]
ChEMBL	Inhibition of recombinant human CA2 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2020) 190: 112112-112112 [PMID:32044580]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2021) 222: 113589-113589 [PMID:34147910]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as inhibition constant incubated for 1 hr prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	ACS Med Chem Lett (2023) 14: 1067-1072 [PMID:37583824]
ChEMBL	Inhibition of cytosolic carbonic anhydrase 2 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2013) 66: 372-379 [PMID:23827177]
ChEMBL	Inhibition of human CA2	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Mean inhibitory constant towards human carbonic anhydrase II determined by stopped-flow method	B	7.91	pKi	12.3	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2315-2320 [PMID:15837316]
ChEMBL	Inhibition of human CA2 pre-incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2020) 63: 7392-7409 [PMID:32463228]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	ACS Med Chem Lett (2017) 8: 963-968 [PMID:28947945]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	ACS Med Chem Lett (2020) 11: 852-856 [PMID:32435395]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2014) 22: 1873-1882 [PMID:24560737]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2014) 22: 3684-3695 [PMID:24878360]
ChEMBL	Inhibition of recombinant human CA2 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2020) 63: 13064-13075 [PMID:33085484]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2018) 61: 3151-3165 [PMID:29566486]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by CO2 hydration-based stopped flow assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2016) 59: 721-732 [PMID:26741028]
ChEMBL	Inhibition of human erythrocyte carbonic anhydrase 2 preincubated for 15 mins prior to testing by bromothymol blue-based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2017) 25: 1260-1265 [PMID:28057408]
ChEMBL	Inhibition of human CA2 incubated for 15 mins by stopped- flow CO2 hydrase assay method	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2020) 201: 112478-112478 [PMID:32659606]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-2 using CO2 as substrate preincubated for 10 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2017) 25: 539-544 [PMID:27919611]
ChEMBL	Inhibition of human CA-2 by stopped flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2014) 57: 9673-9686 [PMID:25358036]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 by stopped flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem Lett (2021) 37: 127856-127856 [PMID:33609663]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition constant preincubated with enzyme for 10 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	>12.1	nM	Ki	Bioorg Med Chem (2020) 28: 115586-115586 [PMID:32631564]
ChEMBL	Inhibition of recombinant human erythrocyte cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2017) 25: 1286-1293 [PMID:28065499]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-2 incubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2018) 61: 4961-4977 [PMID:29746127]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 10 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2013) 21: 5228-5232 [PMID:23842519]
ChEMBL	Inhibition of human CA2 by stopped-flow carbon dioxide hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2020) 200: 112439-112439 [PMID:32485532]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 2 after 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2017) 127: 691-702 [PMID:27823879]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem Lett (2021) 49: 128309-128309 [PMID:34371130]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2015) 23: 2368-2376 [PMID:25846066]
ChEMBL	Inhibition of recombinant human CA2 preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem Lett (2021) 45: 128147-128147 [PMID:34052322]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2018) 154: 210-219 [PMID:29803994]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2021) 217: 113351-113351 [PMID:33744685]
ChEMBL	Binding affinity to human carbonic anhydrase 2 by stopped flow CO2 hydration method	B	7.92	pKi	12.1	nM	Ki	ACS Med Chem Lett (2018) 9: 725-729 [PMID:30034608]
ChEMBL	Inhibition of recombinant human CA2 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2018) 61: 5765-5770 [PMID:29912561]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2023) 66: 1616-1633 [PMID:36626645]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	ACS Med Chem Lett (2017) 8: 1213-1217 [PMID:29259736]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2021) 221: 113486-113486 [PMID:33965860]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2021) 64: 11432-11444 [PMID:34283610]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2014) 84: 240-246 [PMID:25019479]
ChEMBL	Inhibition of human CA2 incubated for 15 mins prior to testing by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2022) 228: 114026-114026 [PMID:34920169]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2022) 65: 824-837 [PMID:34958217]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2022) 228: 113997-113997 [PMID:34902732]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2014) 22: 141-147 [PMID:24332658]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-2 preincubated for 10 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2017) 25: 5726-5732 [PMID:28887000]
ChEMBL	Inhibition of human CA2 pre-incubated for 10 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2017) 25: 5373-5379 [PMID:28789908]
ChEMBL	Binding affinity to human CA2 assessed as inhibition constant incubated for 6 hrs by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2023) 246: 115011-115011 [PMID:36516582]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2014) 87: 186-196 [PMID:25255434]
ChEMBL	Inhibition of human human carbonic anhydrase II assessed as inhibition constant incubated for 15 min by stopped-flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	ACS Med Chem Lett (2024) 15: 470-477 [PMID:38628786]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2017) 25: 3567-3573 [PMID:28522267]
ChEMBL	Inhibition of human recombinant CA2 assessed as inhibition constant pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2022) 65: 13946-13966 [PMID:36201615]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-2-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2013) 21: 1386-1391 [PMID:23352754]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 2 assessed as inhibition constant incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2023) 66: 10010-10026 [PMID:37436184]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 10 mins prior to testing by stopped flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2017) 25: 1666-1671 [PMID:28161252]
ChEMBL	Inhibition of recombinant human CA1I assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2023) 66: 5703-5718 [PMID:37022308]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem Lett (2022) 59: 128581-128581 [PMID:35066141]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 assessed as inhibition constant incubated for 10 mins by phenol red dye based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2022) 234: 114247-114247 [PMID:35305463]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition constant preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2022) 227: 113956-113956 [PMID:34731762]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as inhibition constant incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2024) 67: 3018-3038 [PMID:38301036]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2017) 60: 2456-2469 [PMID:28253618]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as inhibition constant preincubated for 15 mins and measured for 10 to 100 sec by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2022) 243: 114793-114793 [PMID:36201858]
ChEMBL	Binding affinity to human CA2 assessed as inhibition constant	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2020) 28: 115813-115813 [PMID:33069128]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	ACS Med Chem Lett (2023) 14: 810-819 [PMID:37312840]
ChEMBL	Inhibition of recombinant human Carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2017) 60: 3154-3164 [PMID:28272885]
ChEMBL	Inhibition of recombinant full length human carbonic anhydrase-2 assessed as reduction in CO2 hydration after 15 mins by phenol red dye based stopped flow assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2019) 163: 443-452 [PMID:30530195]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of human carbonic anhydrase 2 using saturated CO2 as substrate incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2016) 24: 2882-2886 [PMID:27137360]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2019) 181: 111565-111565 [PMID:31387062]
ChEMBL	Inhibition of human carbonic anhydrase 2-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2014) 76: 284-290 [PMID:24589484]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2019) 181: 111586-111586 [PMID:31401537]
ChEMBL	Inhibition of human recombinant CA2 preincubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2016) 24: 3043-3051 [PMID:27234893]
ChEMBL	Inhibition of recombinant human CA2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2019) 182: 111600-111600 [PMID:31419777]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 min to 72 hrs by stopped flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2016) 24: 2907-2913 [PMID:27166574]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 10 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2019) 183: 111702-111702 [PMID:31542715]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2018) 157: 1214-1222 [PMID:30193219]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 assessed as CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye-based stopped-flow assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2018) 156: 430-443 [PMID:30015076]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as Ki by stopped-flow carbon dioxide hydration assay	B	7.92	pKi	12.1	nM	Ki	RSC Med Chem (2023) 14: 144-153 [PMID:36760748]
ChEMBL	Inhibition of recombinant human CA2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of cytosolic human carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2018) 150: 678-686 [PMID:29571155]
ChEMBL	Inhibition of human carbonic anhydrase-2 incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3208-3212 [PMID:26105196]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem Lett (2016) 26: 3892-3895 [PMID:27423482]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated 15 mins prior to testing by CO2 hydration based stopped-flow assay	B	7.92	pKi	12.1	nM	Ki	ACS Med Chem Lett (2018) 9: 947-951 [PMID:30258546]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase-2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1626-1630 [PMID:23414801]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 1396-1403 [PMID:23290254]
ChEMBL	Inhibition of human carbonic anhydrase-2 cytosolic isoform after 15 mins by Stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 2314-2318 [PMID:23490152]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029]
ChEMBL	Inhibition of recombinant human CA2 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2013) 56: 4691-4700 [PMID:23647428]
ChEMBL	Inhibition of human carbonic anhydrase-2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 2925-2931 [PMID:23623256]
ChEMBL	Inhibition of human recombinant CA2 by CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins to 6 hrs by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2013) 56: 5773-5781 [PMID:23815159]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 3949-3957 [PMID:23706268]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 after 6 hrs by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 4502-4510 [PMID:23769167]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 5130-5138 [PMID:23859774]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 5799-5805 [PMID:23910989]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human carbonic anhydrase2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602]
ChEMBL	Inhibition of full length human cytosolic carbonic anhydrase-2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2013) 56: 8512-8520 [PMID:24128000]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6706-6710 [PMID:24210500]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6759-6763 [PMID:24189056]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2013) 56: 9623-9634 [PMID:24200125]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human CA2 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394]
ChEMBL	Inhibition of human CA2 cytosolic isoform after 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1127-1132 [PMID:24461298]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 after 6 hrs by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 1522-1528 [PMID:24513186]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 1821-1831 [PMID:24560739]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2-mediated CO2 hydration after 6 hrs by stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1256-1260 [PMID:24518190]
ChEMBL	Inhibition of human recombinant cytosolic human carbonic anhydrase-2 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1776-1779 [PMID:24589511]
ChEMBL	Inhibition of human carbonic anhydrase 2-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 2643-2647 [PMID:24713308]
ChEMBL	Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL	Inhibition of human cloned cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydrase assay method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 6945-6952 [PMID:25456084]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4006-4010 [PMID:25011913]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2014) 5: 793-796 [PMID:25050167]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2014) 5: 826-830 [PMID:25050173]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase Assay	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2014) 5: 927-930 [PMID:25147616]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2014) 24: 5185-5189 [PMID:25442309]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2014) 57: 9152-9167 [PMID:25310626]
ChEMBL	Inhibition of human full length CA2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 6353-6359 [PMID:25438758]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4389-4396 [PMID:25168745]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4402-4406 [PMID:25168748]
ChEMBL	Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 5133-5140 [PMID:25194929]
ChEMBL	Inhibition of human CA-2 after 15 mins by stopped-flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 5883-5890 [PMID:25267005]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 1430-1436 [PMID:25753329]
ChEMBL	Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 1421-1429 [PMID:25757603]
ChEMBL	Inhibition of human recombinant CA-2 after 15 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 1828-1840 [PMID:25766630]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 by CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2015) 58: 1494-1501 [PMID:25581127]
ChEMBL	Inhibition of human cytosolic form of carbonic anhydrase-2 assessed as CO2 hydration activity incubated for 15 mins prior to testing by stopped flow method	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2015) 96: 425-435 [PMID:25912674]
ChEMBL	Inhibition of human recombinant carbonic anhdydrase-2 expressed in Escherichia coli pre-incubated for 6 hrs by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2015) 58: 3975-3983 [PMID:25875209]
ChEMBL	Inhibition of human carbonic anhydrase-2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay based Lineweaver-Burk plot method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 3674-3680 [PMID:25921266]
ChEMBL	Inhibition of human CA2 after 15 mins by stopped-flow/Co2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 4405-4409 [PMID:26145820]
ChEMBL	Inhibition of human carbonic anhydrase 2 by by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli preincubated for 15 mins by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 4649-4659 [PMID:26088336]
ChEMBL	Inhibition of human carbonic anhydrase-2 by CO2 hydration reaction based colorimetric stopped-flow method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 4831-4838 [PMID:26068018]
ChEMBL	Inhibition of human recombinant CA2 expressed in Escherichia coli by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2015) 58: 6630-6638 [PMID:26203869]
ChEMBL	Inhibition of human carbonic anhydrase-2	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3281-3284 [PMID:26073006]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 5619-5625 [PMID:26233796]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3550-3555 [PMID:26174556]
ChEMBL	Inhibition of human carbonic anhydrase-2 incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
ChEMBL	Inhibition of human carbonic anhydrase-2 by CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3550-3555 [PMID:26174556]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3850-3853 [PMID:26233435]
ChEMBL	Inhibition of full length human carbonic anhydrase-2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2015) 6: 819-821 [PMID:26191373]
ChEMBL	Inhibition of carbonic anhydrase-2 (unknown origin)	B	7.92	pKi	12	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 expressed in Escherichia coli incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 6573-6580 [PMID:26422787]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 6 hrs by stopped flow carbon-di-oxide hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 6955-6966 [PMID:26432607]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 7219-7225 [PMID:26498393]
ChEMBL	Inhibition of human carbonic anhydrase-2 assessed as CO2 hydration activity by stopped-flow method	B	7.92	pKi	12	nM	Ki	J Med Chem (2015) 58: 8564-8572 [PMID:26497049]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5636-5641 [PMID:26520662]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli preincubated for 6 hrs by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2015) 103: 583-593 [PMID:26408817]
ChEMBL	Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863]
ChEMBL	Inhibition of human carbonic anhydrase-2 preincubated for 15 mins by stopped flow CO2 dehydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 20-25 [PMID:26678172]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 921-927 [PMID:26796953]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 894-901 [PMID:26795114]
ChEMBL	Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 982-988 [PMID:26803577]
ChEMBL	Inhibition of human carbonic anhydrase-2 using p-nitrophenyl acetate as substrate by esterase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1337-1341 [PMID:26804228]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 1095-1105 [PMID:26810710]
ChEMBL	Inhibition of human carbonic anhydrase 2 for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 976-981 [PMID:26810836]
ChEMBL	Inhibition of human carbonic anhydrase 2 by Stopped-Flow CO2 Hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2016) 59: 462-473 [PMID:26688270]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 1402-1407 [PMID:26875933]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1253-1259 [PMID:26832216]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow carbon dioxide hydrase assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2016) 110: 259-266 [PMID:26840366]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 1648-1652 [PMID:26951893]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 3413-3417 [PMID:27283786]
ChEMBL	Inhibition of human recombinant CA2 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 3548-3555 [PMID:27298005]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 3643-3648 [PMID:27316543]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 3612-3617 [PMID:27290692]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2016) 59: 5077-5088 [PMID:27144971]
ChEMBL	Inhibition of human carbonic anhydrase-2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 4406-4409 [PMID:27469982]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 4100-4107 [PMID:27396930]
ChEMBL	Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped flow carbon dioxide hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2016) 59: 10692-10704 [PMID:27933963]
ChEMBL	Inhibition of human full length carbonic anhydrase 2	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2016) 26: 5867-5870 [PMID:27884694]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2017) 27: 86-89 [PMID:27876475]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-2 preincubated for 6 hrs by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 677-683 [PMID:27939347]
ChEMBL	Inhibitory activity against human carbonic anhydrase II (hCA II) by using esterase assay method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 3757-3762 [PMID:15203157]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins by stopped flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 1456-1464 [PMID:28111158]
ChEMBL	Inhibition of recombinant human CA2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2017) 60: 1159-1170 [PMID:28075587]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2017) 127: 521-530 [PMID:28109946]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-2 assessed as reduction in enzyme-catalyzed hydration activity using CO2 as substrate preincubated for 15 mins followed substrate addition measured after 10 to 100 sec by phenol red dye based stopped flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 1914-1925 [PMID:28237553]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition of CO2 hydration incubated for 15 mins prior to testing by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 2010-2015 [PMID:28238511]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 2577-2582 [PMID:28343756]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 2569-2576 [PMID:28347633]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 10 mins measured for 5 to 10 secs by stopped flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 3583-3589 [PMID:28416101]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 2782-2788 [PMID:28389112]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 2 pretreated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 2518-2523 [PMID:28302505]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 10 mins by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 3093-3097 [PMID:28400084]
ChEMBL	Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 2524-2529 [PMID:28318894]
ChEMBL	Inhibition of human CA2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of human CA2 incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 4800-4804 [PMID:28754318]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 assessed as reduction in CO2 hydration pretreated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2017) 8: 792-796 [PMID:28835790]
ChEMBL	Inhibition of human carbonic anhydrase-2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2017) 8: 1194-1198 [PMID:29152053]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2017) 8: 1314-1319 [PMID:29259754]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2018) 61: 5380-5394 [PMID:29851481]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2018) 151: 363-375 [PMID:29635168]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2018) 152: 1-9 [PMID:29684705]
ChEMBL	Binding affinity to human carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2018) 155: 545-551 [PMID:29909339]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2017) 139: 250-262 [PMID:28802125]
ChEMBL	Inhibition of recombinant human full-length carbonic anhydrase 2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2017) 8: 941-946 [PMID:28947941]
ChEMBL	Inhibition of human CA2 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2018) 61: 6328-6338 [PMID:29962205]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2018) 157: 28-36 [PMID:30071407]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2019) 184: 111768-111768 [PMID:31629164]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2019) 62: 4174-4192 [PMID:30925064]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2020) 63: 2470-2488 [PMID:31972093]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2019) 62: 7233-7249 [PMID:31287314]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2019) 182: 111642-111642 [PMID:31476557]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins by phenol red staining-based stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2019) 27: 115086-115086 [PMID:31515057]
ChEMBL	Inhibition of recombinant human carbonic anhydrase2 preincubated for 10 mins followed by CO2 solution addition by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2019) 27: 115090-115090 [PMID:31515058]
ChEMBL	Inhibition of recombinant human CA2 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2020) 185: 111811-111811 [PMID:31693947]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2019) 162: 147-160 [PMID:30445264]
ChEMBL	Inhibition of full length human CA 2	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2019) 168: 301-314 [PMID:30826507]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2019) 27: 1588-1594 [PMID:30846402]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated with enzyme for 1 hr prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2020) 63: 5185-5200 [PMID:32364386]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration after 15 mins by phenol red staining-based stopped flow assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2019) 164: 92-105 [PMID:30594030]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2016) 59: 5857-5867 [PMID:27253845]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 10 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2020) 11: 633-637 [PMID:32435363]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by stopped-flow CO2 hydration kinetic assay based Cheng-Prusoff equation analysis	B	7.92	pKi	12	nM	Ki	J Med Chem (2020) 63: 7422-7444 [PMID:32519851]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as inhibitory constant incubated for 6 hrs by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2020) 28: 115496-115496 [PMID:32327349]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2020) 28: 115329-115329 [PMID:32007388]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2020) 200: 112300-112300 [PMID:32460112]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2020) 207: 112745-112745 [PMID:32877804]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2021) 209: 112875-112875 [PMID:33059188]
ChEMBL	Inhibition of human CA2 incubated for 15 mins by stopped-flow CO2 hydration kinetic assay based Cheng-Prusoff equation analysis	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2021) 214: 113260-113260 [PMID:33581552]
ChEMBL	Inhibition of human CA2 measured by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2021) 48: 128249-128249 [PMID:34237441]
ChEMBL	Inhibition of recombinant human CA2 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2021) 218: 113360-113360 [PMID:33773285]
ChEMBL	Inhibition of human CA2 by stopped- flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2021) 216: 113283-113283 [PMID:33667848]
ChEMBL	Inhibition of recombinant human CA2 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2021) 220: 113490-113490 [PMID:33975138]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2022) 228: 114004-114004 [PMID:34847409]
ChEMBL	Binding affinity to human CA2 assessed as inhibition constant by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2022) 238: 114412-114412 [PMID:35551035]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped flow CO2 assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2022) 70: 128809-128809 [PMID:35605838]
ChEMBL	Inhibition of recombinant human CA 2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2022) 232: 114190-114190 [PMID:35182815]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 10 mins and measured by phenol red based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2022) 65: 14655-14672 [PMID:36269278]
ChEMBL	Inhibition of human recombinant CA2	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of human CA2	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 10 mins prior to testing by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 857-863 [PMID:28024887]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	J Med Chem (2000) 43: 4884-4892 [PMID:11123998]
ChEMBL	Inhibition against human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 231-234 [PMID:14684333]
ChEMBL	Compound was evaluated for inhibition against human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 217-223 [PMID:14684331]
ChEMBL	Inhibition of cloned isozyme, human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2001) 11: 575-582 [PMID:11229775]
ChEMBL	Inhibition of human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 225-229 [PMID:14684332]
ChEMBL	Inhibition constant (Ki) against human cloned carbonic anhydrase II (CAH)	B	7.92	pKi	12	nM	Ki	J Med Chem (2003) 46: 2187-2196 [PMID:12747790]
ChEMBL	Inhibition of human recombinant carbonic anhydrase II (CA2)	B	7.92	pKi	12	nM	Ki	J Med Chem (2000) 43: 4542-4551 [PMID:11087579]
ChEMBL	Inhibitory activity against human cloned isoenzyme carbonic anhydrase II (hCA II), by esterase method.	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2003) 13: 837-840 [PMID:12617903]
ChEMBL	Inhibitory activity against human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 869-873 [PMID:15012984]
ChEMBL	Inhibition of human cytosolic isozyme Carbonic anhydrase II at 20 degree C	B	7.92	pKi	12	nM	Ki	J Med Chem (2004) 47: 1272-1279 [PMID:14971907]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase II (hCA II)	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2003) 13: 841-845 [PMID:12617904]
ChEMBL	Inhibitory effect on human Carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	J Med Chem (2002) 45: 312-320 [PMID:11784136]
ChEMBL	Inhibition of human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL	Inhibitory activity against human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase II (CA2)	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560]
ChEMBL	Inhibition of human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	J Med Chem (2003) 46: 2197-2204 [PMID:12747791]
ChEMBL	Inhibition constant evaluated for the inhibition of human CA II (Carbonic anhydrase II)	B	7.92	pKi	12	nM	Ki	J Med Chem (2004) 47: 2337-2347 [PMID:15084132]
ChEMBL	Inhibitory activity against human carbonic anhydrase II.	B	7.92	pKi	12	nM	Ki	J Med Chem (2003) 46: 5471-5477 [PMID:14640555]
ChEMBL	In vitro inhibitory activity against human carbonic anhydrase II (hCAII)	B	7.92	pKi	12	nM	Ki	J Med Chem (2004) 47: 2796-2804 [PMID:15139757]
ChEMBL	Inhibitory activity against Human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	J Med Chem (2002) 45: 1466-1476 [PMID:11906288]
ChEMBL	Inhibitory activity against Carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	J Med Chem (2005) 48: 2121-2125 [PMID:15771455]
ChEMBL	Inhibitory constant against cytosolic human Carbonic anhydrase II using CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibitory activity against human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853]
ChEMBL	Inhibitory activity against cytosolic human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816]
ChEMBL	Inhibitory potency against human cloned Carbonic anhydrase II expressed in Escherichia coli strain BL21	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 367-372 [PMID:15603956]
ChEMBL	Ki value against human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Ki value against human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Ki value against human carbonic anhydrase II (hCA II)	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894]
ChEMBL	Inhibitory activity against human carbonic anhydrase II (hCAII)	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli BL21	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5781-5786 [PMID:15501040]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5775-5780 [PMID:15501039]
ChEMBL	Inhibitory activity against human Carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	J Med Chem (2004) 47: 5224-5229 [PMID:15456265]
ChEMBL	Inhibitory constant against human Carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091]
ChEMBL	Inhibition constant against human (cloned) isozyme (hCA II) by CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2005) 48: 4834-4841 [PMID:16033263]
ChEMBL	Inhibition constant against human recombinant carbonic anhydrase II	F	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3302-3306 [PMID:15908201]
ChEMBL	Inhibitory constant against human Carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325]
ChEMBL	Inhibitory constant against human Carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2347-2352 [PMID:15837323]
ChEMBL	Inhibition constant against human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against human Carbonic anhydrase II (hCA II)	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibitory activity against human cloned Carbonic anhydrase II by the CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4872-4876 [PMID:16165351]
ChEMBL	Inhibitory activity against human recombinant cytosolic CA2	B	7.92	pKi	12	nM	Ki	J Med Chem (2005) 48: 7860-7866 [PMID:16302824]
ChEMBL	Inhibition of recombinant human cytosolic isozyme CA II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 5192-5196 [PMID:16203142]
ChEMBL	Inhibitory activity against cloned human CA2	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL	Inhibition of human recombinant CA2	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077]
ChEMBL	Inhibition of human CA2	B	7.92	pKi	12	nM	Ki	J Med Chem (2006) 49: 2743-2749 [PMID:16640335]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2006) 49: 5544-5551 [PMID:16942027]
ChEMBL	Inhibition of human cloned CA2 by CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of human cloned CA2 by CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2006) 49: 6539-6548 [PMID:17064072]
ChEMBL	Inhibition of human cloned CA2 by stopped-flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase method	B	7.92	pKi	12	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human recombinant isozyme CA2 by CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2007) 50: 1651-1657 [PMID:17343373]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2007) 15: 2298-2311 [PMID:17276072]
ChEMBL	Inhibition of human recombinant CA2 after 15 mins by CO2 hydration stopped flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2007) 17: 2685-2691 [PMID:17376683]
ChEMBL	Inhibition of human cloned CA2 by CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760]
ChEMBL	Inhibition of human cloned carbonic anhydrase2 by CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2007) 15: 6975-6984 [PMID:17822907]
ChEMBL	Inhibition of human recombinant CA 2 assessed as CO2 hydration by stopped flow kinetic assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2007) 15: 7229-7236 [PMID:17826101]
ChEMBL	Inhibition of human carbonic anhydrase 2	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human cloned CA2 by CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2008) 51: 1945-1953 [PMID:18307288]
ChEMBL	Inhibition of human full length carbonic anhydrase 2 by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3593-3596 [PMID:18501600]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3475-3480 [PMID:18513964]
ChEMBL	Inhibition of human recombinant full length CA2 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant CA2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2009) 17: 553-557 [PMID:19097911]
ChEMBL	Inhibition of human recombinant CA2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of human recombinant full length CA2 by stopped-flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human carbonic anhydrase 2 measured by CO2 hydration reaction assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 650-653 [PMID:19121582]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2008) 18: 6332-6335 [PMID:18990571]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL	Inhibition of human cloned CA2 by stopped-flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2008) 51: 7968-7979 [PMID:19053764]
ChEMBL	Inhibition of human erythrocytes carbonic anhydrase 2 by CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2009) 52: 4853-4859 [PMID:19580287]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2642-2645 [PMID:19375309]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow CO2 assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2009) 17: 4894-4899 [PMID:19539481]
ChEMBL	Inhibition of human full length cytosolic carbonic anhydrase 2 after 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human cloned CA2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2009) 52: 6421-6432 [PMID:19827837]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301]
ChEMBL	Inhibition of human recombinant CA2 by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5825-5828 [PMID:19751975]
ChEMBL	Inhibition of human cloned full length carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4929-4932 [PMID:19651511]
ChEMBL	Inhibition of human CA2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow carbon dioxide hydrase assay method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2178-2182 [PMID:20211561]
ChEMBL	Inhibition of human recombinant CA2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2010) 53: 2913-2926 [PMID:20201556]
ChEMBL	Inhibition of full length human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human carbonic anhydrase 2	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3623-3627 [PMID:20478708]
ChEMBL	Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2010) 18: 4873-4878 [PMID:20598552]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2010) 18: 5498-5503 [PMID:20624682]
ChEMBL	Inhibition of human cloned CA2 after 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2010) 18: 5081-5089 [PMID:20580561]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 102-105 [PMID:21145236]
ChEMBL	Inhibition of human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2011) 19: 243-248 [PMID:21163660]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
ChEMBL	Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL	Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 min by CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL	Inhibition of human carbonic anhydrase 2 after 15 mins by Lineweaver-Burk plot	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of human recombinant alpha-carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2011) 54: 1682-1692 [PMID:21332115]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2521-2526 [PMID:21402476]
ChEMBL	Inhibition of human carbonic anhydrase 2 after 6 hrs by Lineweaver-Burk plot analysis	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2515-2520 [PMID:21420862]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay at pH 8.3	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3591-3595 [PMID:21570835]
ChEMBL	Inhibition of human CA2 by CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3216-3221 [PMID:21549597]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3170-3173 [PMID:19435663]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2011) 54: 3977-3981 [PMID:21506569]
ChEMBL	Inhibition of human full length cytosolic isoform of carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2975-2979 [PMID:21470859]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2011) 19: 3732-3738 [PMID:21620713]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL	Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human recombinant CA2 by CO2 hydration based stopped flow assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2011) 54: 6905-6918 [PMID:21851094]
ChEMBL	Inhibition of human carbonic anhydrase 2-catalyzed CO2 hydration activity by stopped flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5892-5896 [PMID:21852133]
ChEMBL	Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2012) 20: 2392-2404 [PMID:22370338]
ChEMBL	Inhibition of human CA2 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2012) 55: 1721-1730 [PMID:22276570]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	7.92	pKi	12	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL	Inhibition of human recombinant full length CA2-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2012) 55: 3891-3899 [PMID:22443141]
ChEMBL	Inhibition of human CA2 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2012) 22: 5801-5806 [PMID:22901388]
ChEMBL	Inhibition of full length human CA2 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2012) 22: 7142-7145 [PMID:23072866]
ChEMBL	Inhibition of human recombinant wild type CA2 by stopped-flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2013) 23: 256-260 [PMID:23200251]
ChEMBL	Inhibition of full length human recombinant CA2 cytosolic isoform after 6 hrs by stopped-flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2013) 56: 293-300 [PMID:23241068]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2013) 56: 1761-1771 [PMID:23391336]
ChEMBL	Inhibition of human CA2 by stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2013) 23: 715-719 [PMID:23265898]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 1465-1469 [PMID:23078755]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 10 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 1451-1464 [PMID:23168081]
ChEMBL	Inhibition of recombinant human carbonic anhydrase II assessed as inhibition constant incubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2023) 66: 8118-8129 [PMID:37283561]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2023) 66: 10558-10578 [PMID:37501287]
ChEMBL	Inhibition of human CA II assessed as inhibition constant by stopped-flow CO2 hydrase assay method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2023) 95: 129479-129479 [PMID:37704010]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as inhibition constant preincubated for 15 mins and measured by phenol red based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2023) 94: 117467-117467 [PMID:37722299]
ChEMBL	Binding affinity to human recombinant CA2 assessed as inhibition constant incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2023) 66: 14824-14842 [PMID:37902628]
ChEMBL	Inhibition of carbonic anhydrase-2 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by bromine thymol blue indicator based assay	B	7.97	pKi	10.7	nM	Ki	Bioorg Med Chem (2017) 25: 3547-3554 [PMID:28511907]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	8	pKi	10	nM	Ki	Bioorg Med Chem (2017) 25: 2210-2217 [PMID:28256371]
ChEMBL	Inhibition of human CA2 by Lineweaver-Burk plot analysis	B	8	pKi	10	nM	Ki	ACS Med Chem Lett (2018) 9: 1045-1050 [PMID:30344915]
ChEMBL	Inhibition of human recombinant CA2 by CO2 hydration stopped flow assay	B	8	pKi	10	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8	pKi	10	nM	Ki	ACS Med Chem Lett (2020) 11: 1022-1027 [PMID:32435420]
ChEMBL	Inhibition of human carbonic anhydrase 2 after 15 mins by stopped flow carbon dioxide hydration assay	B	8	pKi	10	nM	Ki	ACS Med Chem Lett (2018) 9: 462-467 [PMID:29795760]
ChEMBL	Binding affinity to human recombinant CA2 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	8.05	pKi	9	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by dansylamide (DNSA) competition assay	B	8.1	pKi	7.94	nM	Ki	Bioorg Med Chem Lett (2013) 23: 939-943 [PMID:23317571]
ChEMBL	Inhibitory activity against human carbonic anhydrase II	B	8.15	pKi	7	nM	Ki	Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846]
ChEMBL	Dissociation constant against Carbonic anhydrase II was reported in experiment 1	B	8.22	pKi	6	nM	Ki	J Med Chem (2002) 45: 3588-3602 [PMID:12166932]
ChEMBL	Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assay	B	8.48	pKi	3.3	nM	Ki	J Med Chem (2005) 48: 1941-1947 [PMID:15771438]
ChEMBL	Inhibition of human CAH2 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	9.03	pKi	0.94	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Binding affinity to human CA2 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysis	B	9.46	pKi	0.34	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human carbonic anhydrase-2 preincubated for 15 mins by stopped flow CO2 dehydration method	B	10.92	pKi	0.01	nM	Ki	Bioorg Med Chem (2016) 24: 104-112 [PMID:26682703]
ChEMBL	Inhibition of esterase activity of human carbonic anhydrase 2 by CO2 hydration method	B	5.08	pIC50	8300	nM	IC50	Bioorg Med Chem (2009) 17: 3295-3301 [PMID:19362844]
ChEMBL	Inhibition of human carbonic anhydrase 2 hydratase activity by spectrophotometry	B	5.09	pIC50	8200	nM	IC50	Eur J Med Chem (2010) 45: 4769-4773 [PMID:20724038]
ChEMBL	Inhibition of esterase-activity of human erythrocytes CA2 by spectrophotometry	B	5.35	pIC50	4500	nM	IC50	Bioorg Med Chem (2010) 18: 930-938 [PMID:20006931]
ChEMBL	Inhibition of human carbonic anhydrase 2 esterase activity by spectrophotometry	B	5.39	pIC50	4100	nM	IC50	Eur J Med Chem (2010) 45: 4769-4773 [PMID:20724038]
ChEMBL	Inhibition of CO2-hydratase activity of human carbonic anhydrase 2 by CO2 hydration method	B	5.41	pIC50	3900	nM	IC50	Bioorg Med Chem (2009) 17: 3295-3301 [PMID:19362844]
ChEMBL	Inhibition of human erythrocytes CA2 by Lineweaver-Burke analysis	B	5.42	pIC50	3800	nM	IC50	Bioorg Med Chem (2010) 18: 930-938 [PMID:20006931]
ChEMBL	Inhibition of hydratase-activity of human erythrocytes CA2 by CO2-hydration method	B	5.55	pIC50	2800	nM	IC50	Bioorg Med Chem (2010) 18: 930-938 [PMID:20006931]
ChEMBL	Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 30 mins by colorimetric analysis	B	5.92	pIC50	1190	nM	IC50	Bioorg Med Chem (2019) 27: 3889-3901 [PMID:31345748]
ChEMBL	Inhibition of Carbonic anhydrase 2 (unknown origin) using p-nitrophenyl acetate as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by microplate reader method	B	5.92	pIC50	1190	nM	IC50	Eur J Med Chem (2023) 246: 114958-114958 [PMID:36470105]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 10 mM dithiothreitol	B	6.36	pIC50	441	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 1.00 mM dithiothreitol	B	6.44	pIC50	362	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.25 mM dithiothreitol	B	6.45	pIC50	351	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.10 mM dithiothreitol	B	6.55	pIC50	285	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.05 mM dithiothreitol	B	6.55	pIC50	283	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human full length CAH2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in esterase activity using p-nitrophenyl acetate substrate by stopped flow CO2 hydration assay	B	6.62	pIC50	240	nM	IC50	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method	B	6.66	pIC50	220	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1941-1943 [PMID:24650641]
ChEMBL	Inhibition of human erythrocyte CA2 using 4-nitrophenyl acetate as substrate by spectrophotometry	B	6.76	pIC50	175	nM	IC50	Eur J Med Chem (2020) 198: 112392-112392 [PMID:32388113]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as conversion of 4-nitrophenyl acetate to 4-nitrophnolate after 5 mins	B	6.82	pIC50	152	nM	IC50	Eur J Med Chem (2010) 45: 1225-1229 [PMID:20036446]
ChEMBL	Inhibition of human CA-2 using p-nitro-phenylacetate as substrate after 3 mins by UV-Vis spectrophotometry	B	6.91	pIC50	123.5	nM	IC50	Bioorg Med Chem (2015) 23: 2598-2605 [PMID:25863492]
ChEMBL	Inhibition of human CA2 by stopped-flow assay	B	6.94	pIC50	115.05	nM	IC50	Bioorg Med Chem (2021) 39: 116140-116140 [PMID:33905966]
ChEMBL	Inhibition of human CA2 by spectrophotometer based analysis	B	6.94	pIC50	115	nM	IC50	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human CA2	B	6.94	pIC50	115	nM	IC50	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA))	B	7	pIC50	101	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 10 mM beta-mercaptoethanol	B	7.01	pIC50	98.3	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 10 mM threitol	B	7.03	pIC50	92.5	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 1.00 mM threitol	B	7.05	pIC50	89.9	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.25 mM threitol	B	7.11	pIC50	77.8	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 1.00 mM beta-mercaptoethanol	B	7.16	pIC50	69.7	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.10 mM threitol	B	7.16	pIC50	68.6	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.01 mM dithiothreitol	B	7.17	pIC50	68	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as 4-nitrophenyl phosphate hydrolysis	B	7.2	pIC50	63	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2267-2271 [PMID:18353640]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.25 mM beta-mercaptoethanol	B	7.22	pIC50	60.4	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 10 mM tris-(carboxyethyl)-phosphine	B	7.25	pIC50	56.5	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.10 mM beta-mercaptoethanol	B	7.27	pIC50	53.1	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.05 mM beta-mercaptoethanol	B	7.31	pIC50	48.9	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 1.00 mM tris-(carboxyethyl)-phosphine	B	7.32	pIC50	48.3	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.25 mM tris-(carboxyethyl)-phosphine	B	7.32	pIC50	48.1	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.10 mM tris-(carboxyethyl)-phosphine	B	7.32	pIC50	47.6	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human CA2 using pNPA as substrate preincubated for 15 mins followed by substrate by absorbance based analysis	B	7.33	pIC50	46.88	nM	IC50	J Med Chem (2023) 66: 11761-11791 [PMID:37585683]
ChEMBL	Inhibition of human carbonic anhydrase 2 using p-nitrophenyl acetate as substrate by UV-VIS spectrophotometric analysis	B	7.35	pIC50	45.1	nM	IC50	Eur J Med Chem (2021) 216: 113300-113300 [PMID:33640672]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay	B	7.43	pIC50	37.5	nM	IC50	Eur J Med Chem (2013) 62: 597-604 [PMID:23429054]
ChEMBL	Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate by spectrophotometric analysis	B	7.43	pIC50	36.85	nM	IC50	Bioorg Med Chem (2016) 24: 2318-2329 [PMID:27068142]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.05 mM threitol	B	7.44	pIC50	36	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.05 mM tris-(carboxyethyl)-phosphine	B	7.46	pIC50	34.3	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human erythrocyte carbonic anhydrase-2 assessed as hydrolysis of 4-nitrophenylacetate	B	7.54	pIC50	29	nM	IC50	J Med Chem (2012) 55: 10909-10917 [PMID:23176597]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as 4-nitrophenyl acetate hydrolysis	B	7.55	pIC50	28	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2267-2271 [PMID:18353640]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as p-nitrophenyl acetate conversion to p-nitrophenolate anion preincubated for 10 mins prior to substrate addition measured for 20 mins by spectrophotometric analysis	B	7.6	pIC50	25	nM	IC50	J Med Chem (2013) 56: 7997-8007 [PMID:24074025]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 pretreated for 15 mins by stopped flow CO2 hydrase assay	B	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2617-2620 [PMID:24813742]
ChEMBL	Inhibition of human CA2 using 4-nitrophenylacetate as substrate by spectrophotometrical analysis	B	7.65	pIC50	22.17	nM	IC50	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of full length carbonic anhydrase-2 in human erythrocytes	B	7.7	pIC50	20.02	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3496-3499 [PMID:23664215]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-2 expressed in Escherichia coli BL21 (DE3) using p-nitrophenyl acetate as substrate preincubated for 10 mins followed by substrate addition	B	7.7	pIC50	<=20	nM	IC50	J Med Chem (2023) 66: 2789-2803 [PMID:36735827]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.01 mM threitol	B	7.73	pIC50	18.5	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.01 mM beta-mercaptoethanol	B	7.79	pIC50	16.2	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.01 mM tris-(carboxyethyl)-phosphine	B	7.79	pIC50	16.2	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.8	pIC50	16	nM	IC50	Eur J Med Chem (2021) 210: 112994-112994 [PMID:33234343]
ChEMBL	Inhibition of human recombinant CA2 using 4-nitrophenylacetate as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.8	pIC50	16	nM	IC50	Eur J Med Chem (2013) 66: 1-11 [PMID:23777898]
ChEMBL	Inhibition of CA-2 (unknown origin) after 15 mins by CO2 hydration assay	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2014) 24: 3422-3425 [PMID:24948563]
ChEMBL	Inhibition of human carbonic anhydrase 2 using p-nitrophenyl acetate as substrate by UV-VIS spectrophotometric analysis	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem (2020) 28: 115424-115424 [PMID:32209296]
ChEMBL	Compound was tested for inhibition of human carbonic anhydrase (hCA II)	B	7.86	pIC50	13.7	nM	IC50	Bioorg Med Chem Lett (2003) 13: 863-865 [PMID:12617909]
ChEMBL	Inhibition of human carbonic anhydrase 2 expressed in Escherichia coli BL21 D3 strain using p-nitrophenyl acetate as substrate by UV/visible spectrophotometry	B	7.89	pIC50	13	nM	IC50	Eur J Med Chem (2018) 155: 13-23 [PMID:29852328]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate pretreated for 15 mins prior to test by spectrophotometric method	B	7.89	pIC50	13	nM	IC50	Eur J Med Chem (2017) 132: 1-10 [PMID:28334643]
ChEMBL	Inhibition of human recombinant CA2 incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.9	pIC50	12.5	nM	IC50	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate	B	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2021) 51: 128291-128291 [PMID:34324968]
ChEMBL	Inhibitory activity against human carbonic anhydrase II was determined	B	7.92	pIC50	12	nM	IC50	J Med Chem (2004) 47: 550-557 [PMID:14736236]
ChEMBL	Inhibitory activity of compound against human carbonic anhydrase II	F	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2004) 14: 337-341 [PMID:14698154]
ChEMBL	Inhibition of recombinant human CA2 using 4-nitrophenylacetate as substrate by esterase assay	B	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2021) 53: 128420-128420 [PMID:34728369]
ChEMBL	Inhibition of human CA2 using 4-nitrophenylacetate as substrate incubated for 10 mins prior to testing by spectrophotometry based esterase assay	B	7.92	pIC50	12	nM	IC50	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of carbonic anhydrase 2 in human erythrocytes by CO2 hydration-based fluorimetric assay	B	8	pIC50	<10	nM	IC50	J Med Chem (2013) 56: 9019-9030 [PMID:24205976]
ChEMBL	In vitro inhibition of human Carbonic Anhydrase II	B	8	pIC50	10	nM	IC50	J Med Chem (1989) 32: 2486-2492 [PMID:2810337]
ChEMBL	50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytes	B	8	pIC50	10	nM	IC50	J Med Chem (1989) 32: 2548-2554 [PMID:2585443]
ChEMBL	In vitro inhibition of purified human erythrocyte carbonic anhydrase II	B	8	pIC50	10	nM	IC50	J Med Chem (1993) 36: 2134-2141 [PMID:8340917]
ChEMBL	50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree C	B	8	pIC50	9.9	nM	IC50	J Med Chem (1989) 32: 2510-2513 [PMID:2585439]
ChEMBL	Inhibition of human carbonic anhydrase 2	B	8.05	pIC50	8.9	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human erythrocyte carbonic anhydrase-2	B	8.17	pIC50	6.7	nM	IC50	Eur J Med Chem (2017) 125: 190-196 [PMID:27657811]
ChEMBL	Inhibition of carbonic anhydrase-2 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by bromine thymol blue indicator based assay	B	8.17	pIC50	6.7	nM	IC50	Bioorg Med Chem (2017) 25: 3547-3554 [PMID:28511907]
ChEMBL	Activity against human carbonic anhydrase II	B	8.22	pIC50	6	nM	IC50	J Med Chem (1994) 37: 1646-1651 [PMID:8201598]
ChEMBL	50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree C	B	8.47	pIC50	3.4	nM	IC50	J Med Chem (1989) 32: 2510-2513 [PMID:2585439]
ChEMBL	Inhibitory activity towards Carbonic anhydrase II	F	8.47	pIC50	3.4	nM	IC50	J Med Chem (2002) 45: 3588-3602 [PMID:12166932]
Carbonic anhydrase II in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2283] [UniProtKB: P00921]
ChEMBL	Inhibition of bovine erythrocyte carbonic anhydrase 2 using 4-nitrophenyl acetate substrate by photometric assay	B	6.86	pKi	137	nM	Ki	Eur J Med Chem (2014) 86: 95-102 [PMID:25147151]
ChEMBL	Inhibition of bovine erythrocyte carbonic anhydrase 2 using p-nitrophenyl acetate as substrate preincubated for 10 mins before substrate addition measured after 30 mins by spectrophotometric analysis	B	6.02	pIC50	960	nM	IC50	Eur J Med Chem (2014) 78: 140-150 [PMID:24681391]
ChEMBL	Inhibition of bovine carbonic anhydrase 2 assessed as hydrolysis of p-nitrophenyl acetate after 30 mins by spectrophotometric method	B	6.02	pIC50	960	nM	IC50	Bioorg Med Chem (2015) 23: 2435-2444 [PMID:25865133]
Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451]
ChEMBL	Inhibition of human carbonic anhydrase 3 at pH7 and 37 degC by fluorescent thermal shift assay	B	4.4	pKd	40000	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 3 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	4.4	pKd	40000	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 3 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	5.34	pKd	4600	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of carbonic anhydrase-3 (unknown origin)	B	4.6	pKi	>25000	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human CA3 by stopped-flow CO2 hydrase assay	B	4.7	pKi	20000	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of human carbonic anhydrase 3 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	4.7	pKi	20000	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human recombinant carbonic anhydrase3 cytosolic isoform expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	4.7	pKi	20000	nM	Ki	Bioorg Med Chem (2013) 21: 6929-6936 [PMID:24103430]
ChEMBL	Inhibition of human CA3 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration method	B	4.7	pKi	20000	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 3 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	4.7	pKi	20000	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of human CAH3 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	5	pKi	>10000	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of recombinant human CA3 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	5	pKi	>10000	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of human carbonic anhydrase 3 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	5	pKi	>10000	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of human carbonic anhydrase 3	B	8.51	pKi	3.1	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 3 phosphatase activity using 4-nitrophenyl phosphate as substrate preincubated for 10 mins prior to substrate addition by stopped flow cytometry	B	5.19	pIC50	6500	nM	IC50	Bioorg Med Chem Lett (2012) 22: 1560-1564 [PMID:22277279]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 3 hydrolysis activity using 4-nitrophenyl acetate as substrate preincubated for 10 mins prior to substrate addition by stopped flow cytometry	B	6.08	pIC50	840	nM	IC50	Bioorg Med Chem Lett (2012) 22: 1560-1564 [PMID:22277279]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL	Inhibition of human carbonic anhydrase 4 at pH7 and 37 degC by fluorescent thermal shift assay	B	7	pKd	100	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 4 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	7.06	pKd	87	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 4 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	7.92	pKd	12	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human CA4 using 4NPA as substrate for 3 mins by Lineweaver burk plot analysis	B	6.24	pKi	578	nM	Ki	Eur J Med Chem (2012) 54: 423-428 [PMID:22687439]
ChEMBL	Inhibition of human carbonic anhydrase 4 esterase activity using 4-nitrophenylacetate as substrate	B	6.24	pKi	578	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL	Inhibition of human carbonic anhydrase 4 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	6.24	pKi	578	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 4 using 4-nitrophenyl acetate as substrate assessed as inhibition constant by spectrophotometric analysis	B	6.45	pKi	354.9	nM	Ki	Bioorg Med Chem (2023) 77: 117111-117111 [PMID:36463726]
ChEMBL	Inhibition of cloned isozyme, human carbonic anhydrase IV	B	6.66	pKi	220	nM	Ki	Bioorg Med Chem Lett (2001) 11: 575-582 [PMID:11229775]
ChEMBL	Inhibition of human carbonic anhydrase 4 assessed as reduction in CO2 hydration preincubated for 15 mins to 2 hrs by phenol red dye based stopped flow CO2 hydrase assay	B	7.12	pKi	75.4	nM	Ki	ACS Med Chem Lett (2019) 10: 1205-1210 [PMID:31413806]
ChEMBL	Inhibition of human carbonic anhydrase 4 incubated for 15 mins by phenol red staining-based stopped flow CO2 hydrase assay	B	7.12	pKi	75	nM	Ki	Bioorg Med Chem (2019) 27: 115086-115086 [PMID:31515057]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-4 using CO2 as substrate preincubated for 10 mins by stopped-flow CO2 hydrase assay	B	7.13	pKi	74.3	nM	Ki	Bioorg Med Chem (2017) 25: 539-544 [PMID:27919611]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.13	pKi	74.2	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of recombinant human CA4 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.13	pKi	74.2	nM	Ki	J Med Chem (2017) 60: 1159-1170 [PMID:28075587]
ChEMBL	Inhibition of human carbonic anhydrase 4 by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human full length membrane-bound carbonic anhydrase 4 after 15 mins by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human recombinant CA4 by stopped flow CO2 hydrase assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human CA4 by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of full length human carbonic anhydrase 4 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 after 15 mins by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration method	B	7.13	pKi	74	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of human carbonic anhydrase 4 after 15 mins by Lineweaver-Burk plot	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of human CA4 by CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3216-3221 [PMID:21549597]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins by CO2 hydration method	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human carbonic anhydrase 4 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human CA4 preincubated for 15 mins by stopped-flow CO2 hydration method	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of carbonic anhydrase-4 (unknown origin)	B	7.13	pKi	74	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2015) 23: 7219-7225 [PMID:26498393]
ChEMBL	Inhibition of human carbonic anhydrase-4 preincubated for 15 mins by stopped flow CO2 dehydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2016) 24: 20-25 [PMID:26678172]
ChEMBL	Inhibition of human recombinant CA4 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2016) 24: 3548-3555 [PMID:27298005]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2016) 59: 5077-5088 [PMID:27144971]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 expressed in Escherichia coli assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2017) 27: 86-89 [PMID:27876475]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 assessed as reduction in CO2 hydration preincubated for 15 mins by stopped flow assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2017) 25: 1456-1464 [PMID:28111158]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2017) 127: 521-530 [PMID:28109946]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-4 assessed as reduction in enzyme-catalyzed hydration activity using CO2 as substrate preincubated for 15 mins followed substrate addition measured after 10 to 100 sec by phenol red dye based stopped flow assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2017) 25: 1914-1925 [PMID:28237553]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 incubated for 10 mins prior to testing by stopped flow CO2 hydrase assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2017) 25: 1666-1671 [PMID:28161252]
ChEMBL	Inhibition of recombinant human membrane bound carbonic anhydrase 4 pretreated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2017) 25: 2518-2523 [PMID:28302505]
ChEMBL	Inhibition of human CA4 by stopped-flow CO2 hydrase assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	ACS Med Chem Lett (2017) 8: 1105-1109 [PMID:29057059]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.13	pKi	74	nM	Ki	ACS Med Chem Lett (2017) 8: 1213-1217 [PMID:29259736]
ChEMBL	Inhibition of human carbonic anhydrase 4 incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.13	pKi	74	nM	Ki	ACS Med Chem Lett (2017) 8: 1314-1319 [PMID:29259754]
ChEMBL	Inhibition of recombinant human CA4 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2018) 61: 5765-5770 [PMID:29912561]
ChEMBL	Inhibition of human membrane-anchored carbonic anhydrase 4 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2018) 151: 363-375 [PMID:29635168]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2018) 152: 1-9 [PMID:29684705]
ChEMBL	Binding affinity to human carbonic anhydrase 4 by stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2018) 155: 545-551 [PMID:29909339]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-4 incubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2018) 61: 4961-4977 [PMID:29746127]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 4 by stopped-flow CO2 hydrase assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2017) 139: 250-262 [PMID:28802125]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	ACS Med Chem Lett (2017) 8: 963-968 [PMID:28947945]
ChEMBL	Inhibition of membrane bound human carbonic anhydrase 4 by stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2018) 150: 678-686 [PMID:29571155]
ChEMBL	Inhibition of recombinant human CA4 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2018) 157: 1214-1222 [PMID:30193219]
ChEMBL	Inhibition of human carbonic anhydrase 4 assessed as reduction in CO2 hydration incubated for 1 hr by phenol red staining-based stopped flow assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2019) 183: 111698-111698 [PMID:31539777]
ChEMBL	Inhibition of human carbonic anhydrase 4 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2019) 62: 7233-7249 [PMID:31287314]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2019) 181: 111586-111586 [PMID:31401537]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2019) 182: 111642-111642 [PMID:31476557]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of human CA4 preincubated for 15 mins by stopped-flow CO2 hydration kinetic assay based Cheng-Prusoff equation analysis	B	7.13	pKi	74	nM	Ki	J Med Chem (2020) 63: 7422-7444 [PMID:32519851]
ChEMBL	Inhibition of recombinant human CA4 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2020) 63: 13064-13075 [PMID:33085484]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2021) 212: 113035-113035 [PMID:33303238]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2021) 209: 112875-112875 [PMID:33059188]
ChEMBL	Inhibition of human carbonic anhydrase 4 assessed as inhibition constant preincubated for 15 mins and measured for 10 to 100 sec by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2022) 243: 114793-114793 [PMID:36201858]
ChEMBL	Inhibitory activity against human carbonic anhydrase IV (hCAIV)	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibition of human cloned CA4 by stopped-flow CO2 hydration method	B	7.13	pKi	74	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human recombinant CA4 after 15 mins by CO2 hydration stopped flow assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2007) 17: 2685-2691 [PMID:17376683]
ChEMBL	Inhibition of human carbonic anhydrase 4	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 4 by stopped flow CO2 hydrase assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA4 by stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of truncated human cloned membrane-associated carbonic anhydrase 4 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2008) 18: 6332-6335 [PMID:18990571]
ChEMBL	Inhibition of human cloned CA4 by stopped-flow CO2 hydration method	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human recombinant CA4	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of human CA4 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2023) 66: 1616-1633 [PMID:36626645]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 4 assessed as inhibition constant incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2023) 66: 10010-10026 [PMID:37436184]
ChEMBL	Inhibition of recombinant human carbonic anhydrase IV assessed as inhibition constant incubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2023) 66: 8118-8129 [PMID:37283561]
ChEMBL	Inhibition of recombinant human CA4 preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2021) 45: 128147-128147 [PMID:34052322]
ChEMBL	Inhibition of recombinant human CA4 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2021) 220: 113490-113490 [PMID:33975138]
ChEMBL	Inhibition of recombinant human CA4 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2021) 225: 113793-113793 [PMID:34507012]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2021) 221: 113486-113486 [PMID:33965860]
ChEMBL	Inhibition of human CA4 incubated for 15 mins prior to testing by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2022) 228: 114026-114026 [PMID:34920169]
ChEMBL	Binding affinity to human recombinant CA4 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of recombinant human CA4 pre-incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2022) 65: 13143-13157 [PMID:36121705]
ChEMBL	Inhibition of human recombinant CA4 assessed as inhibition constant pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2022) 65: 13946-13966 [PMID:36201615]
ChEMBL	Inhibition of recombinant human membrane-associated carbonic anhydrase 4 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.15	pKi	70	nM	Ki	Bioorg Med Chem (2017) 25: 2210-2217 [PMID:28256371]
GtoPdb	-	-	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 367-72 [PMID:15603956]; Bioorg Med Chem Lett (2010) 20: 4376-81 [PMID:20605094]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2023) 66: 10558-10578 [PMID:37501287]
ChEMBL	Inhibition of human secreted carbonic anhydrase 4 measured by CO2 hydration reaction assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2009) 19: 650-653 [PMID:19121582]
ChEMBL	Inhibition of human CAH4 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	8.07	pKi	8.6	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
Carbonic anhydrase IV in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL281] [UniProtKB: Q95323]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV from lung microsomes	B	6.66	pKi	220	nM	Ki	J Med Chem (2000) 43: 4884-4892 [PMID:11123998]
ChEMBL	Inhibition of bovine carbonic anhydrase IV (CA4) from bovine lung microsomes	B	6.66	pKi	220	nM	Ki	J Med Chem (2000) 43: 4542-4551 [PMID:11087579]
ChEMBL	Inhibition of bovine membrane bound isozyme carbonic anhydrase IV isolated from microsomes at 20 degree C	B	6.66	pKi	220	nM	Ki	J Med Chem (2004) 47: 1272-1279 [PMID:14971907]
ChEMBL	Inhibitory effect on bovine Carbonic anhydrase IV	B	6.66	pKi	220	nM	Ki	J Med Chem (2002) 45: 312-320 [PMID:11784136]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV (CA4), obtained from bovine lung microsomes	B	6.66	pKi	220	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560]
ChEMBL	In vitro inhibitory activity against bovine carbonic anhydrase IV (CAIV)	B	6.66	pKi	220	nM	Ki	J Med Chem (2004) 47: 2796-2804 [PMID:15139757]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV	B	6.66	pKi	220	nM	Ki	J Med Chem (2002) 45: 1466-1476 [PMID:11906288]
ChEMBL	Inhibitory activity against Carbonic anhydrase IV isolated from bovine lung	B	6.92	pKi	120	nM	Ki	Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV (bCAIV)	B	7.15	pKi	70	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase isozyme IV isolated from bovine lung microsomes, by esterase assay method.	B	7.15	pKi	70	nM	Ki	Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL	Compound was evaluated for inhibition against bovine carbonic anhydrase IV	B	7.15	pKi	70	nM	Ki	Bioorg Med Chem Lett (2004) 14: 217-223 [PMID:14684331]
ChEMBL	Inhibition constant against bovine Carbonic anhydrase IV, isolated from lung microsomes	B	7.15	pKi	70	nM	Ki	J Med Chem (2003) 46: 2187-2196 [PMID:12747790]
ChEMBL	Inhibitory activity against CA4 isolated from bovine lung microsomes	B	7.15	pKi	70	nM	Ki	Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146]
ChEMBL	Inhibitory activity against carbonic anhydrase IV from bovine lung microsomes	B	7.15	pKi	70	nM	Ki	Bioorg Med Chem Lett (2004) 14: 869-873 [PMID:15012984]
ChEMBL	Inhibitory activity against carbonic anhydrase isolated from bovine lung microsome (bCA IV)	B	7.15	pKi	70	nM	Ki	Bioorg Med Chem Lett (2003) 13: 841-845 [PMID:12617904]
ChEMBL	Inhibition constant evaluated for the inhibition of bovine CA IV (Carbonic anhydrase IV)	B	7.15	pKi	70	nM	Ki	J Med Chem (2004) 47: 2337-2347 [PMID:15084132]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV was determined	B	7.15	pIC50	70	nM	IC50	J Med Chem (2004) 47: 550-557 [PMID:14736236]
ChEMBL	Inhibitory activity of compound against bovine carbonic anhydrase IV	F	7.15	pIC50	70	nM	IC50	Bioorg Med Chem Lett (2004) 14: 337-341 [PMID:14698154]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL	Inhibition of chimeric carbonic anhydrase 9 (unknown origin) expressing with full length CA2 (1 to 260) at pH7 and 37 degC by fluorescent thermal shift assay	B	7.3	pKd	50	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of human carbonic anhydrase 9 at pH7 and 37 degC by isothermal titration calorimetry	B	7.66	pKd	22	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 9 expressed in mammalian cell expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	7.68	pKd	21	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human carbonic anhydrase 9 at pH7 and 37 degC by fluorescent thermal shift assay	B	7.7	pKd	20	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of chimeric carbonic anhydrase 9 (unknown origin) expressing with full length CA2 (1 to 260) at pH7 and 37 degC by isothermal titration calorimetry	B	7.85	pKd	14	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to human CA9 catalytic domain expressed in mammalian expression system assessed as thermodynamic equilibrium constant at pH 7 by SPR assay	B	8.07	pKd	8.5	nM	Kd	J Med Chem (2018) 61: 2292-2302 [PMID:29466001]
ChEMBL	Inhibition of human carbonic anhydrase 9 at pH7 and 25 degC by stopped-flow kinetic inhibition assay	B	8.17	pKd	6.7	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of chimeric carbonic anhydrase 9 (unknown origin) expressing with full length CA2 (1 to 260) at pH7 and 25 degC by stopped-flow kinetic inhibition assay	B	8.3	pKd	<5	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 9 expressed in mammalian cell expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	8.54	pKd	2.9	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to human CA9 catalytic domain expressed in mammalian expression system assessed as intrinsic thermodynamic equilibrium constant at pH 7 by SPR assay	B	9	pKd	1	nM	Kd	J Med Chem (2018) 61: 2292-2302 [PMID:29466001]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	4.6	pKi	25000	nM	Ki	Eur J Med Chem (2020) 186: 111896-111896 [PMID:31784185]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX at 0.09 uM	B	4.6	pKi	25000	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 assessed as inhibition constant incubated for 1 hr prior to testing by phenol red based stopped-flow CO2 hydration assay	B	5.24	pKi	5700	nM	Ki	Bioorg Med Chem (2022) 67: 116805-116805 [PMID:35635929]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 9 using 4-nitrophenyl acetate as substrate assessed as inhibition constant by spectrophotometric analysis	B	6.36	pKi	437.2	nM	Ki	Bioorg Med Chem (2023) 77: 117111-117111 [PMID:36463726]
ChEMBL	Inhibition of recombinant human tumor-associated carbonic anhydrase 9 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.52	pKi	30	nM	Ki	Bioorg Med Chem (2017) 25: 2210-2217 [PMID:28256371]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	26	nM	Ki	Eur J Med Chem (2022) 228: 114008-114008 [PMID:34871842]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped flow CO2 assay	B	7.59	pKi	26	nM	Ki	Bioorg Med Chem Lett (2022) 70: 128809-128809 [PMID:35605838]
ChEMBL	Inhibition of human CA9 measured after 15 mins by stopped flow carbon dioxide anhydrase assay	B	7.59	pKi	26	nM	Ki	Eur J Med Chem (2021) 225: 113800-113800 [PMID:34482273]
ChEMBL	Inhibition of recombinant human CA9 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.59	pKi	26	nM	Ki	Eur J Med Chem (2021) 220: 113490-113490 [PMID:33975138]
ChEMBL	Inhibition of recombinant human carbonic anhydrase9 preincubated for 10 mins followed by CO2 solution addition by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	26	nM	Ki	Bioorg Med Chem (2019) 27: 115090-115090 [PMID:31515058]
ChEMBL	Inhibition of recombinant human CA9 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	26	nM	Ki	Eur J Med Chem (2020) 185: 111811-111811 [PMID:31693947]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2017) 8: 1213-1217 [PMID:29259736]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2018) 143: 1931-1941 [PMID:29146134]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of human CA9 pre-incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.59	pKi	25.8	nM	Ki	J Med Chem (2020) 63: 7392-7409 [PMID:32463228]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2020) 11: 852-856 [PMID:32435395]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	J Med Chem (2021) 64: 11432-11444 [PMID:34283610]
ChEMBL	Inhibition of human carbonic anhydrase-9 catalytic domain assessed as reduction in CO2 hydration after 15 mins by phenol red dye based stopped flow assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2019) 163: 443-452 [PMID:30530195]
ChEMBL	Binding affinity to human CA9 assessed as inhibition constant incubated for 6 hrs by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2023) 246: 115011-115011 [PMID:36516582]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-9 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	7.59	pKi	25.8	nM	Ki	Bioorg Med Chem (2017) 25: 3567-3573 [PMID:28522267]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as inhibition constant incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2022) 243: 114793-114793 [PMID:36201858]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	J Med Chem (2019) 62: 7233-7249 [PMID:31287314]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2019) 181: 111586-111586 [PMID:31401537]
ChEMBL	Inhibition of human CA9 pre-incubated for 10 mins by stopped-flow CO2 hydrase assay	B	7.59	pKi	25.8	nM	Ki	Bioorg Med Chem (2017) 25: 5373-5379 [PMID:28789908]
ChEMBL	Inhibition of recombinant human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2019) 182: 111600-111600 [PMID:31419777]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-9 preincubated for 10 mins by stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Bioorg Med Chem (2017) 25: 5726-5732 [PMID:28887000]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2018) 154: 210-219 [PMID:29803994]
ChEMBL	Inhibition of human human carbonic anhydrase IX assessed as inhibition constant incubated for 15 min by stopped-flow CO2 hydrase assay	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2024) 15: 470-477 [PMID:38628786]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2021) 212: 113035-113035 [PMID:33303238]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 by stopped flow CO2 hydrase assay	B	7.59	pKi	25.8	nM	Ki	Bioorg Med Chem Lett (2021) 37: 127856-127856 [PMID:33609663]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 assessed as inhibition constant preincubated with enzyme for 10 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Bioorg Med Chem (2020) 28: 115586-115586 [PMID:32631564]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-9 catalytic domain incubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.59	pKi	25.8	nM	Ki	J Med Chem (2018) 61: 4961-4977 [PMID:29746127]
ChEMBL	Inhibition of human CA9 by stopped-flow carbon dioxide hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2020) 200: 112439-112439 [PMID:32485532]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 catalytic domain preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2017) 8: 963-968 [PMID:28947945]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Bioorg Med Chem Lett (2021) 49: 128309-128309 [PMID:34371130]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated 15 mins prior to testing by CO2 hydration based stopped-flow assay	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2018) 9: 947-951 [PMID:30258546]
ChEMBL	Inhibition of transmembrane human carbonic anhydrase 9 by stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2018) 150: 678-686 [PMID:29571155]
ChEMBL	Inhibition of full length human CA9 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Bioorg Med Chem (2021) 44: 116279-116279 [PMID:34216985]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2021) 217: 113351-113351 [PMID:33744685]
ChEMBL	Inhibition of recombinant human CA9 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2021) 221: 113486-113486 [PMID:33965860]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as inhibition constant incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	J Med Chem (2024) 67: 3018-3038 [PMID:38301036]
ChEMBL	Inhibition of human CA9 incubated for 15 mins prior to testing by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2022) 228: 114026-114026 [PMID:34920169]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	J Med Chem (2022) 65: 824-837 [PMID:34958217]
ChEMBL	Binding affinity to human recombinant CA9 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 assessed as CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye-based stopped-flow assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2018) 156: 430-443 [PMID:30015076]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2018) 157: 1214-1222 [PMID:30193219]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 assessed as inhibition constant incubated for 10 mins by phenol red dye based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2022) 234: 114247-114247 [PMID:35305463]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 assessed as inhibition constant preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2022) 227: 113956-113956 [PMID:34731762]
ChEMBL	Inhibition of human recombinant CA9 preincubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.59	pKi	25.8	nM	Ki	Bioorg Med Chem (2016) 24: 3043-3051 [PMID:27234893]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 10 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2019) 183: 111702-111702 [PMID:31542715]
ChEMBL	Binding affinity to human CA9 assessed as inhibition constant	B	7.59	pKi	25.8	nM	Ki	Bioorg Med Chem (2020) 28: 115813-115813 [PMID:33069128]
ChEMBL	Inhibition of recombinant human CA9 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	J Med Chem (2020) 63: 13064-13075 [PMID:33085484]
ChEMBL	Inhibition of human carbonic anhydrase 9 after 15 mins by stopped flow carbon dioxide hydration assay	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2018) 9: 462-467 [PMID:29795760]
ChEMBL	Inhibition of recombinant human CA9 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	J Med Chem (2018) 61: 5765-5770 [PMID:29912561]
ChEMBL	Binding affinity to human carbonic anhydrase 9 by stopped flow CO2 hydration method	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2018) 9: 725-729 [PMID:30034608]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 10 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2020) 193: 112219-112219 [PMID:32203788]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.7	nM	Ki	Eur J Med Chem (2022) 228: 113997-113997 [PMID:34902732]
ChEMBL	Inhibition of recombinant human CA9 preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.7	nM	Ki	Bioorg Med Chem Lett (2021) 45: 128147-128147 [PMID:34052322]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.7	nM	Ki	J Med Chem (2023) 66: 1616-1633 [PMID:36626645]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	7.59	pKi	25.7	nM	Ki	Bioorg Med Chem Lett (2022) 59: 128581-128581 [PMID:35066141]
ChEMBL	Inhibition of recombinant human CA9 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.7	nM	Ki	Eur J Med Chem (2021) 225: 113793-113793 [PMID:34507012]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.7	nM	Ki	ACS Med Chem Lett (2023) 14: 810-819 [PMID:37312840]
ChEMBL	Inhibition of human recombinant CA9 assessed as inhibition constant pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.7	nM	Ki	J Med Chem (2022) 65: 13946-13966 [PMID:36201615]
ChEMBL	Inhibition of recombinant human CA1X assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	7.59	pKi	25.7	nM	Ki	J Med Chem (2023) 66: 5703-5718 [PMID:37022308]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as Ki by stopped-flow carbon dioxide hydration assay	B	7.59	pKi	25.7	nM	Ki	RSC Med Chem (2023) 14: 144-153 [PMID:36760748]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.6	pKi	25.4	nM	Ki	J Med Chem (2017) 60: 6428-6439 [PMID:28658574]
ChEMBL	Inhibition of human CA9 after 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25.4	nM	Ki	Eur J Med Chem (2018) 146: 47-59 [PMID:29407972]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25.4	nM	Ki	Bioorg Med Chem (2013) 21: 5228-5232 [PMID:23842519]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-9-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	7.6	pKi	25.4	nM	Ki	Bioorg Med Chem (2013) 21: 1386-1391 [PMID:23352754]
ChEMBL	Inhibition of recombinant human Carbonic anhydrase 9 assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	7.6	pKi	25.4	nM	Ki	J Med Chem (2017) 60: 3154-3164 [PMID:28272885]
ChEMBL	Inhibition of human CA9 incubated for 15 mins by stopped- flow CO2 hydrase assay method	B	7.6	pKi	25.4	nM	Ki	Eur J Med Chem (2020) 201: 112478-112478 [PMID:32659606]
ChEMBL	Inhibition of recombinant human membrane bound carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.6	pKi	25.3	nM	Ki	Bioorg Med Chem (2017) 25: 1286-1293 [PMID:28065499]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 9 after 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25.3	nM	Ki	Eur J Med Chem (2017) 127: 691-702 [PMID:27823879]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.6	pKi	25.3	nM	Ki	Bioorg Med Chem Lett (2016) 26: 3892-3895 [PMID:27423482]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.6	pKi	25.2	nM	Ki	J Med Chem (2017) 60: 9003-9011 [PMID:29048889]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25.2	nM	Ki	Bioorg Med Chem (2017) 25: 2569-2576 [PMID:28347633]
ChEMBL	Inhibition of carbonic anhydrase 9 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25.2	nM	Ki	Eur J Med Chem (2013) 66: 372-379 [PMID:23827177]
ChEMBL	Inhibition of human carbonic anhydrase 9 pre-incubated for 15 mins by stopped flow carbon dioxide hydrase assay	B	7.6	pKi	25.2	nM	Ki	J Med Chem (2016) 59: 10692-10704 [PMID:27933963]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 by stopped flow CO2 hydration assay	B	7.6	pKi	25.2	nM	Ki	Eur J Med Chem (2019) 162: 147-160 [PMID:30445264]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 10 mins prior to testing by stopped flow CO2 hydrase assay	B	7.6	pKi	25.2	nM	Ki	Bioorg Med Chem (2017) 25: 1666-1671 [PMID:28161252]
ChEMBL	Inhibition of recombinant human CA9 catalytic domain preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25.1	nM	Ki	J Med Chem (2017) 60: 1159-1170 [PMID:28075587]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.6	pKi	25.1	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5636-5641 [PMID:26520662]
ChEMBL	Inhibition of human carbonic anhydrase-9 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 2925-2931 [PMID:23623256]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 3949-3957 [PMID:23706268]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 9 after 6 hrs by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 4502-4510 [PMID:23769167]
ChEMBL	Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 5130-5138 [PMID:23859774]
ChEMBL	Inhibition of human membrane bound carbonic anhydrase 9 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human carbonic anhydrase-9 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2013) 23: 5646-5649 [PMID:23993330]
ChEMBL	Inhibition of human carbonic anhydrase9 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602]
ChEMBL	Inhibition of recombinant human catalytic domain of carbonic anhydrase-9 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2013) 56: 8512-8520 [PMID:24128000]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6759-6763 [PMID:24189056]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2013) 56: 9623-9634 [PMID:24200125]
ChEMBL	Inhibition of human catalytic domain of carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human CA9 after 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human recombinant transmembrane carbonic anhydrase 9 after 6 hrs by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 1522-1528 [PMID:24513186]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 9 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 1873-1882 [PMID:24560737]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
ChEMBL	Inhibition of human carbonic anhydrase 9-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 76: 284-290 [PMID:24589484]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 1821-1831 [PMID:24560739]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9-mediated CO2 hydration after 6 hrs by stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1256-1260 [PMID:24518190]
ChEMBL	Inhibition of human recombinant transmembrane tumor associated carbonic anhydrase-9 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1776-1779 [PMID:24589511]
ChEMBL	Inhibition of human carbonic anhydrase 9-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 2643-2647 [PMID:24713308]
ChEMBL	Inhibition of human cloned transmembrane tumor-associated catalytic domain of carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 3684-3695 [PMID:24878360]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydrase assay method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 6945-6952 [PMID:25456084]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2014) 5: 793-796 [PMID:25050167]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 84: 240-246 [PMID:25019479]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydrase Assay	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2014) 5: 927-930 [PMID:25147616]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2014) 24: 5185-5189 [PMID:25442309]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2014) 57: 9152-9167 [PMID:25310626]
ChEMBL	Inhibition of human CA-9 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2014) 57: 9673-9686 [PMID:25358036]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 6353-6359 [PMID:25438758]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 87: 186-196 [PMID:25255434]
ChEMBL	Inhibition of human CA-9 after 15 mins by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 5883-5890 [PMID:25267005]
ChEMBL	Inhibition of human tumor-associated carbonic anhydrase 9 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 1430-1436 [PMID:25753329]
ChEMBL	Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 1421-1429 [PMID:25757603]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 2368-2376 [PMID:25846066]
ChEMBL	Inhibition of human recombinant CA-9 after 15 mins by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 1828-1840 [PMID:25766630]
ChEMBL	Inhibition of human membrane associated form of carbonic anhydrase-9 assessed as CO2 hydration activity incubated for 15 mins prior to testing by stopped flow method	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2015) 96: 425-435 [PMID:25912674]
ChEMBL	Inhibition of human recombinant carbonic anhdydrase-9 expressed in Escherichia coli pre-incubated for 6 hrs by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2015) 58: 3975-3983 [PMID:25875209]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of human carbonic anhydrase-9 pre-incubated for 15 mins by stopped-flow CO2 hydration assay based Lineweaver-Burk plot method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 3674-3680 [PMID:25921266]
ChEMBL	Inhibition of human carbonic anhydrase 9 by by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli preincubated for 15 mins by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 4649-4659 [PMID:26088336]
ChEMBL	Inhibition of human carbonic anhydrase-9 incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3208-3212 [PMID:26105196]
ChEMBL	Inhibition of human recombinant CA9 expressed in Escherichia coli by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2015) 58: 6630-6638 [PMID:26203869]
ChEMBL	Inhibition of human carbonic anhydrase-9	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3281-3284 [PMID:26073006]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-9 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 5619-5625 [PMID:26233796]
ChEMBL	Inhibition of human carbonic anhydrase-9 incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
ChEMBL	Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3850-3853 [PMID:26233435]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-9 catalytic domain by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2015) 6: 819-821 [PMID:26191373]
ChEMBL	Inhibition of carbonic anhydrase-9 (unknown origin)	B	7.6	pKi	25	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 catalytic domain expressed in Escherichia coli incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 6573-6580 [PMID:26422787]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 6 hrs by stopped flow carbon-di-oxide hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 6955-6966 [PMID:26432607]
ChEMBL	Inhibition of human carbonic anhydrase-9 assessed as CO2 hydration activity by stopped-flow method	B	7.6	pKi	25	nM	Ki	J Med Chem (2015) 58: 8564-8572 [PMID:26497049]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli preincubated for 6 hrs by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2015) 103: 583-593 [PMID:26408817]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 921-927 [PMID:26796953]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 894-901 [PMID:26795114]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 982-988 [PMID:26803577]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 1095-1105 [PMID:26810710]
ChEMBL	Inhibition of human carbonic anhydrase 9 for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 976-981 [PMID:26810836]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain by Stopped-Flow CO2 Hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2016) 59: 462-473 [PMID:26688270]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by CO2 hydration-based stopped flow assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2016) 59: 721-732 [PMID:26741028]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 1402-1407 [PMID:26875933]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow carbon dioxide hydrase assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2016) 110: 259-266 [PMID:26840366]
ChEMBL	Inhibition of human carbonic anhydrase 9 using saturated CO2 as substrate incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 2882-2886 [PMID:27137360]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 min to 72 hrs by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 2907-2913 [PMID:27166574]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 3643-3648 [PMID:27316543]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 3612-3617 [PMID:27290692]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2016) 59: 5077-5088 [PMID:27144971]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-9 preincubated for 6 hrs by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 677-683 [PMID:27939347]
ChEMBL	Inhibition of human recombinant transmembrane tumor associated carbonic anhydrase 9 preincubated for 10 mins prior to testing by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 857-863 [PMID:28024887]
ChEMBL	Inhibition of human CA9 by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2015) 58: 640-650 [PMID:25432060]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-9 assessed as reduction in CO2 hydration preincubated for 10 mins measured for 5 to 10 secs by stopped flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 3583-3589 [PMID:28416101]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 2782-2788 [PMID:28389112]
ChEMBL	Inhibition of recombinant human transmembrane carbonic anhydrase 9 pretreated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 2518-2523 [PMID:28302505]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 10 mins by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 3093-3097 [PMID:28400084]
ChEMBL	Inhibition of recombinant human membrane bound carbonic anhydrase 9 expressed in Escherichia coli pretreated for 15 mins prior to testing by stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 3714-3718 [PMID:28545816]
ChEMBL	Inhibition of human CA9 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 assessed as reduction in CO2 hydration pretreated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2017) 8: 792-796 [PMID:28835790]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 assessed as reduction in CO2 hydration preincubated for 10 mins by stopped flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2018) 26: 3731-3762 [PMID:30017112]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2017) 8: 1314-1319 [PMID:29259754]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2018) 143: 276-282 [PMID:29197732]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2018) 61: 5380-5394 [PMID:29851481]
ChEMBL	Inhibition of human transmembrane tumor-associated carbonic anhydrase 9 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2018) 151: 363-375 [PMID:29635168]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2018) 152: 1-9 [PMID:29684705]
ChEMBL	Binding affinity to human carbonic anhydrase 9 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2018) 155: 545-551 [PMID:29909339]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 9 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2017) 139: 250-262 [PMID:28802125]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 catalytic domain preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2017) 8: 941-946 [PMID:28947941]
ChEMBL	Inhibition of human CA9 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2018) 61: 6328-6338 [PMID:29962205]
ChEMBL	Inhibition of carbonic anhydrase 9 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2018) 61: 10860-10874 [PMID:30433782]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2018) 157: 28-36 [PMID:30071407]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as reduction in CO2 hydration preincubated for 15 mins to 2 hrs by phenol red dye based stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2019) 10: 1205-1210 [PMID:31413806]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as reduction in CO2 hydration incubated for 1 hr by phenol red staining-based stopped flow assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2019) 183: 111698-111698 [PMID:31539777]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2019) 184: 111768-111768 [PMID:31629164]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-9 incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2020) 185: 111843-111843 [PMID:31718943]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 expressed in Escherichia coli GOLD BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2019) 62: 4174-4192 [PMID:30925064]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2019) 10: 661-665 [PMID:30996814]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2019) 179: 547-556 [PMID:31276899]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2020) 63: 2470-2488 [PMID:31972093]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as inhibitory constant incubated for 15 mins by phenol red dye based stopped flow assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2019) 182: 111638-111638 [PMID:31472471]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 1 hr prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2020) 63: 321-333 [PMID:31794211]
ChEMBL	Inhibition of human CA 9 catalytic domain	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2019) 168: 301-314 [PMID:30826507]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as inhibitory constant preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2019) 175: 40-48 [PMID:31071549]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2019) 27: 1588-1594 [PMID:30846402]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as reduction in CO2 hydration after 15 mins by phenol red staining-based stopped flow assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2019) 164: 92-105 [PMID:30594030]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2016) 59: 5857-5867 [PMID:27253845]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated with enzyme for 10 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2020) 11: 633-637 [PMID:32435363]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as inhibitory constant incubated for 6 hrs by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2020) 28: 115496-115496 [PMID:32327349]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2020) 28: 115329-115329 [PMID:32007388]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2018) 61: 3151-3165 [PMID:29566486]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2020) 188: 112021-112021 [PMID:31901743]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2020) 189: 112019-112019 [PMID:31972394]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2020) 200: 112300-112300 [PMID:32460112]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2020) 200: 112449-112449 [PMID:32485534]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2020) 207: 112745-112745 [PMID:32877804]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2021) 209: 112897-112897 [PMID:33038795]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2021) 209: 112875-112875 [PMID:33059188]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated for 10 mins by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2021) 39: 127877-127877 [PMID:33640442]
ChEMBL	Inhibition of recombinant human CA9 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2020) 190: 112112-112112 [PMID:32044580]
ChEMBL	Inhibition of human CA9 measured by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2021) 48: 128249-128249 [PMID:34237441]
ChEMBL	Inhibition of recombinant human CA9 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2021) 218: 113360-113360 [PMID:33773285]
ChEMBL	Inhibition of recombinant human CA9 pre-incubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2021) 218: 113352-113352 [PMID:33774343]
ChEMBL	Inhibition of human CA9 by stopped- flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2021) 216: 113283-113283 [PMID:33667848]
ChEMBL	Inhibition of human CA9 by stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2021) 39: 116140-116140 [PMID:33905966]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2021) 222: 113589-113589 [PMID:34147910]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2022) 228: 114004-114004 [PMID:34847409]
ChEMBL	Binding affinity to human CA9 assessed as inhibition constant by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Binding affinity to human recombinant CA9 assessed as inhibition constant incubated for 6 hrs prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of recombinant human CA9 pre-incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2022) 65: 13143-13157 [PMID:36121705]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2022) 238: 114412-114412 [PMID:35551035]
ChEMBL	Inhibition of recombinant human CA 9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2022) 232: 114190-114190 [PMID:35182815]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated for 10 mins and measured by phenol red based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2022) 65: 14655-14672 [PMID:36269278]
ChEMBL	Binding affinity to human recombinant CA9 assessed as inhibition constant incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2023) 66: 14824-14842 [PMID:37902628]
ChEMBL	Inhibition against human carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 231-234 [PMID:14684333]
ChEMBL	Inhibitory activity against human tumor-associated transmembrane carbonic anhydrase IX.	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 3283-3290 [PMID:15149691]
ChEMBL	Compound was evaluated for inhibition against human carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 217-223 [PMID:14684331]
ChEMBL	Inhibition constant determined against catalytic domain of human cloned carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	J Med Chem (2003) 46: 2187-2196 [PMID:12747790]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 869-873 [PMID:15012984]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase isozyme IX, by CO2 hydrase assay method.	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039]
ChEMBL	Inhibitory concentration against catalytic domain of human cloned carbonic anhydrase IX.	B	7.6	pKi	25	nM	Ki	J Med Chem (2003) 46: 2197-2204 [PMID:12747791]
ChEMBL	Inhibition constant evaluated for the inhibition of human CA IX (Carbonic anhydrase IX)	B	7.6	pKi	25	nM	Ki	J Med Chem (2004) 47: 2337-2347 [PMID:15084132]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX.	B	7.6	pKi	25	nM	Ki	J Med Chem (2003) 46: 5471-5477 [PMID:14640555]
ChEMBL	Inhibitory activity against Carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	J Med Chem (2005) 48: 2121-2125 [PMID:15771455]
ChEMBL	Inhibitory constant against catalytic domain of human carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibitory activity against membrane bound tumor associated human carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816]
ChEMBL	Inhibitory potency against catalytic domain of human Carbonic anhydrase IX expressed in Escherichia coli strain BL21	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 367-372 [PMID:15603956]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5775-5780 [PMID:15501039]
ChEMBL	Inhibitory constant against human Carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091]
ChEMBL	Inhibition constant against human cloned isozyme (hCA IX) by CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2005) 48: 4834-4841 [PMID:16033263]
ChEMBL	Inhibition constant against human recombinant carbonic anhydrase IX catalytic domain	F	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3302-3306 [PMID:15908201]
ChEMBL	Inhibitory constant against human Carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325]
ChEMBL	Inhibitory constant against human Carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2347-2352 [PMID:15837323]
ChEMBL	Inhibition constant against human carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against human Carbonic anhydrase IX (hCA IX)	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibitory activity against catalytic domain of human cloned Carbonic anhydrase IX by the CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4872-4876 [PMID:16165351]
ChEMBL	Inhibition of cloned human transmembrane, tumor-associated isozyme CA IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 5192-5196 [PMID:16203142]
ChEMBL	Inhibitory activity against cloned human CA9	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146]
ChEMBL	Inhibition of human CA9	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 2743-2749 [PMID:16640335]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 5544-5551 [PMID:16942027]
ChEMBL	Inhibition of human cloned CA9 catalytic domain by CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of human cloned CA9 catalytic domain by CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 6539-6548 [PMID:17064072]
ChEMBL	Inhibition of catalytic domain of human cloned CA9 by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of catalytic domain of human recombinant CA IX	B	7.6	pKi	25	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of catalytic domain of human recombinant isozyme CA9 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2007) 50: 1651-1657 [PMID:17343373]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2007) 15: 2298-2311 [PMID:17276072]
ChEMBL	Inhibition of human recombinant CA9 after 15 mins by CO2 hydration stopped flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2007) 17: 2685-2691 [PMID:17376683]
ChEMBL	Inhibition of human cloned catalytic domain CA9 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760]
ChEMBL	Inhibition of catalytic domain of human cloned carbonic anhydrase9 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2007) 15: 6975-6984 [PMID:17822907]
ChEMBL	Inhibition of human carbonic anhydrase 9	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant CA9 by CO2 hydration stopped flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of human CA9 catalytic domain by CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2008) 51: 1945-1953 [PMID:18307288]
ChEMBL	Inhibition of human catalytic domain carbonic anhydrase 9 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human cloned carbonic anhydrase 9 by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3475-3480 [PMID:18513964]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant CA9 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2009) 17: 553-557 [PMID:19097911]
ChEMBL	Inhibition of human recombinant CA9 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human cloned CA9 catalytic domain by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2008) 51: 7968-7979 [PMID:19053764]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human membrane-bound carbonic anhydrase 9 catalytic domain after 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human cloned CA9 catalytic domain by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2009) 52: 6421-6432 [PMID:19827837]
ChEMBL	Inhibition of human recombinant CA9 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain expressed in Sf9 cells by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2009) 17: 7093-7099 [PMID:19773173]
ChEMBL	Inhibition of human CA9 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of human recombinant CA9 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2010) 53: 2913-2926 [PMID:20201556]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human carbonic anhydrase 9	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3623-3627 [PMID:20478708]
ChEMBL	Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 catalytic domain preincubated for 15 mins by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2010) 18: 4873-4878 [PMID:20598552]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 after 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of human cloned catalytic domain of CA9 after 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2010) 18: 5081-5089 [PMID:20580561]
ChEMBL	Inhibition of tumor-associated human carbonic anhydrase 9 preincubated for 15 min by CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain by CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3216-3221 [PMID:21549597]
ChEMBL	Inhibition of human recombinant catalytic domain of carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2975-2979 [PMID:21470859]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human carbonic anhydrase 9 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human recombinant CA9 by CO2 hydration based stopped flow assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2011) 54: 6905-6918 [PMID:21851094]
ChEMBL	Inhibition of human carbonic anhydrase 9-catalyzed CO2 hydration activity by stopped flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5892-5896 [PMID:21852133]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2012) 20: 2392-2404 [PMID:22370338]
ChEMBL	Inhibition of human CA9 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2012) 55: 1721-1730 [PMID:22276570]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2012) 55: 3891-3899 [PMID:22443141]
ChEMBL	Inhibition of human CA9 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2012) 22: 5801-5806 [PMID:22901388]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human recombinant transmembrane CA9 catalytic domain after 6 hrs by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2013) 56: 293-300 [PMID:23241068]
ChEMBL	Inhibition of human CA9 by stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2013) 23: 715-719 [PMID:23265898]
ChEMBL	Inhibition of human carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 1451-1464 [PMID:23168081]
ChEMBL	Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 1396-1403 [PMID:23290254]
ChEMBL	Inhibition of tumor-associated transmembrane human carbonic anhydrase-9 after 15 mins by Stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 2314-2318 [PMID:23490152]
ChEMBL	Inhibition of recombinant human CA9 transmembrane isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2013) 56: 4691-4700 [PMID:23647428]
ChEMBL	Inhibition of human recombinant CA9	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of human CA9	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of recombinant human carbonic anhydrase IX assessed as inhibition constant incubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2023) 66: 8118-8129 [PMID:37283561]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as inhibition constant incubated for 1 hr prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2023) 14: 1067-1072 [PMID:37583824]
ChEMBL	Inhibition of human CA IX assessed as inhibition constant by stopped-flow CO2 hydrase assay method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2023) 95: 129479-129479 [PMID:37704010]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as inhibition constant preincubated for 15 mins and measured by phenol red based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2023) 94: 117467-117467 [PMID:37722299]
ChEMBL	Binding affinity to human CA9 assessed as inhibition constant by stopped flow kinetic assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2023) 250: 115180-115180 [PMID:36796297]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 3757-3762 [PMID:15203157]
ChEMBL	Inhibition of human CA9 by Lineweaver-Burk plot analysis	B	7.7	pKi	20	nM	Ki	ACS Med Chem Lett (2018) 9: 1045-1050 [PMID:30344915]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.7	pKi	20	nM	Ki	ACS Med Chem Lett (2020) 11: 1022-1027 [PMID:32435420]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of full length human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped-flow CO2 hydration assay	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5825-5828 [PMID:19751975]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 catalytic domain expressed in Escherichia coli by stopped-flow CO2 hydration assay	B	8.05	pKi	9	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5825-5828 [PMID:19751975]
ChEMBL	Inhibition of recombinant human CA9 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 181: 111573-111573 [PMID:31394463]
ChEMBL	Inhibition of human CAH9 catalytic domain expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	8.39	pKi	4.1	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of human carbonic anhydrase-9 preincubated for 15 mins by stopped flow CO2 dehydration method	B	10.22	pKi	0.06	nM	Ki	Bioorg Med Chem (2016) 24: 104-112 [PMID:26682703]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 10 mM tris-(carboxyethyl)-phosphine	B	5.67	pIC50	2134	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 10 mM beta-mercaptoethanol	B	5.7	pIC50	1997	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 1.00 mM tris-(carboxyethyl)-phosphine	B	5.75	pIC50	1764	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 10 mM dithiothreitol	B	5.82	pIC50	1524	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 1.00 mM dithiothreitol	B	5.82	pIC50	1520	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.10 mM dithiothreitol	B	5.82	pIC50	1520	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.25 mM dithiothreitol	B	5.82	pIC50	1513	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 1.00 mM beta-mercaptoethanol	B	5.89	pIC50	1297	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 10 mM threitol	B	5.89	pIC50	1294	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human CAH9 catalytic domain expressed in Escherichia coli BL21 (DE3) assessed as reduction in esterase activity using p-nitrophenyl acetate substrate by stopped flow CO2 hydration assay	B	5.89	pIC50	1280	nM	IC50	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 1.00 mM threitol	B	5.93	pIC50	1165	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of Carbonic anhydrase 9 (unknown origin) using p-nitrophenyl acetate as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by microplate reader method	B	5.97	pIC50	1080	nM	IC50	Eur J Med Chem (2023) 246: 114958-114958 [PMID:36470105]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.25 mM tris-(carboxyethyl)-phosphine	B	5.99	pIC50	1024	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.25 mM threitol	B	6	pIC50	999.8	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.05 mM dithiothreitol	B	6.01	pIC50	973	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 pretreated for 15 mins by stopped flow CO2 hydrase assay	B	6.04	pIC50	903	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2617-2620 [PMID:24813742]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 10 mM dithiothreitol	B	6.11	pIC50	775	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 1.00 mM dithiothreitol	B	6.12	pIC50	763	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 10 mM tris-(carboxyethyl)-phosphine	B	6.13	pIC50	746.9	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.25 mM dithiothreitol	B	6.13	pIC50	735	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.10 mM dithiothreitol	B	6.14	pIC50	721	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.05 mM dithiothreitol	B	6.15	pIC50	700	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.10 mM tris-(carboxyethyl)-phosphine	B	6.16	pIC50	694.5	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 10 mM beta-mercaptoethanol	B	6.17	pIC50	680	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.05 mM tris-(carboxyethyl)-phosphine	B	6.17	pIC50	670.3	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 1.00 mM beta-mercaptoethanol	B	6.21	pIC50	622	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.25 mM beta-mercaptoethanol	B	6.39	pIC50	410.3	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 1.00 mM tris-(carboxyethyl)-phosphine	B	6.5	pIC50	318.6	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.10 mM beta-mercaptoethanol	B	6.52	pIC50	304.6	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.25 mM beta-mercaptoethanol	B	6.54	pIC50	286.5	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.10 mM beta-mercaptoethanol	B	6.61	pIC50	243.1	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.10 mM threitol	B	6.63	pIC50	236.1	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.01 mM tris-(carboxyethyl)-phosphine	B	6.66	pIC50	218.8	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 10 mM threitol	B	6.68	pIC50	208.1	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.05 mM threitol	B	6.7	pIC50	200.6	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.01 mM threitol	B	6.74	pIC50	183.3	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 1.00 mM threitol	B	6.75	pIC50	176.8	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.05 mM beta-mercaptoethanol	B	6.76	pIC50	174.8	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.01 mM dithiothreitol	B	6.88	pIC50	132	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.25 mM threitol	B	6.91	pIC50	123.6	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.03	pIC50	94	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1941-1943 [PMID:24650641]
ChEMBL	Inhibition of human carbonic anhydrase 9 using p-nitrophenyl acetate as substrate by UV-VIS spectrophotometric analysis	B	7.06	pIC50	87.2	nM	IC50	Eur J Med Chem (2021) 216: 113300-113300 [PMID:33640672]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.01 mM dithiothreitol	B	7.09	pIC50	82	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of CA-9 (unknown origin) after 15 mins by CO2 hydration assay	B	7.14	pIC50	73	nM	IC50	Bioorg Med Chem Lett (2014) 24: 3422-3425 [PMID:24948563]
ChEMBL	Inhibition of human carbonic anhydrase 9 using 4-NPA as substrate after 3 mins by spectrophotometric analysis	B	7.15	pIC50	70.9	nM	IC50	Eur J Med Chem (2018) 144: 544-556 [PMID:29289880]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.25 mM tris-(carboxyethyl)-phosphine	B	7.19	pIC50	65.2	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.10 mM threitol	B	7.25	pIC50	56.7	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.05 mM beta-mercaptoethanol	B	7.27	pIC50	54	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.10 mM tris-(carboxyethyl)-phosphine	B	7.27	pIC50	53.4	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.05 mM threitol	B	7.28	pIC50	52.5	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.05 mM tris-(carboxyethyl)-phosphine	B	7.31	pIC50	48.7	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.01 mM beta-mercaptoethanol	B	7.35	pIC50	44.3	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.01 mM beta-mercaptoethanol	B	7.38	pIC50	42.1	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.01 mM threitol	B	7.44	pIC50	36.7	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.01 mM tris-(carboxyethyl)-phosphine	B	7.44	pIC50	36.2	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain	B	7.49	pIC50	32	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 using p-nitrophenyl acetate as substrate by UV-VIS spectrophotometric analysis	B	7.51	pIC50	31	nM	IC50	Bioorg Med Chem (2020) 28: 115424-115424 [PMID:32209296]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 using 4-nitrophenylacetate as substrate pretreated for 15 mins prior to test by spectrophotometric method	B	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2017) 132: 1-10 [PMID:28334643]
ChEMBL	Inhibition of human CA9 using 4-nitrophenylacetate as substrate incubated for 10 mins prior to testing by spectrophotometry based esterase assay	B	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of recombinant human CA9 using 4-nitrophenylacetate as substrate by esterase assay	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2021) 53: 128420-128420 [PMID:34728369]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 using 4-nitrophenylacetate as substrate	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2021) 51: 128291-128291 [PMID:34324968]
ChEMBL	Inhibition of recombinant human CA9 using 4-nitrophenylacetate as substrate by esterase assay	B	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2021) 226: 113837-113837 [PMID:34530384]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.55	pIC50	28	nM	IC50	Eur J Med Chem (2021) 210: 112994-112994 [PMID:33234343]
ChEMBL	Inhibition of human recombinant CA9 using 4-nitrophenylacetate as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.55	pIC50	28	nM	IC50	Eur J Med Chem (2013) 66: 1-11 [PMID:23777898]
ChEMBL	Inhibition of human carbonic anhydrase 9 expressed in Escherichia coli BL21 D3 strain using p-nitrophenyl acetate as substrate by UV/visible spectrophotometry	B	7.57	pIC50	27	nM	IC50	Eur J Med Chem (2018) 155: 13-23 [PMID:29852328]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX was determined	B	7.6	pIC50	25	nM	IC50	J Med Chem (2004) 47: 550-557 [PMID:14736236]
ChEMBL	Inhibition of human recombinant CA9 incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.6	pIC50	25	nM	IC50	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human carbonic anhydrase 9	B	7.68	pIC50	21	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase-9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	8.11	pIC50	7.72	nM	IC50	Medchemcomm (2018) 9: 2100-2105 [PMID:30746068]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration assay	B	8.11	pIC50	7.7	nM	IC50	Eur J Med Chem (2013) 62: 597-604 [PMID:23429054]
ChEMBL	Inhibition of GST-tagged recombinant carbonic anhydrase-9 catalytic domain (unknown origin)	B	8.59	pIC50	2.58	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3496-3499 [PMID:23664215]
Carbonic anhydrase-related protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2420] [UniProtKB: O75493]
ChEMBL	Inhibition of recombinant human membrane bound carbonic anhydrase 11 expressed in Escherichia coli pretreated for 15 mins prior to testing by stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 3714-3718 [PMID:28545816]
carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
ChEMBL	Inhibition of human carbonic anhydrase 5A at pH7 and 37 degC by fluorescent thermal shift assay	B	6	pKd	1000	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) in presence of ANS by fluorescent thermal shift assay	B	6	pKd	1000	nM	Kd	Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 5a expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	6.08	pKd	840	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) assessed as intrinsic dissociation constant in presence of ANS by fluorescent thermal shift assay	B	6.48	pKd	333	nM	Kd	Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 5a expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	6.57	pKd	270	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of full length human recombinant mitochondrial carbonic anhydrase 5A pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	4.2	pKi	63000	nM	Ki	Bioorg Med Chem Lett (2008) 18: 6332-6335 [PMID:18990571]
ChEMBL	Inhibition of human CAH5A expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	6.96	pKi	108.7	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of human mitochondrial carbonic anhydrase 5a after 6 hrs by stopped flow CO2 hydrase assay	B	7.19	pKi	64	nM	Ki	Bioorg Med Chem (2013) 21: 4502-4510 [PMID:23769167]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.2	pKi	63.1	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of recombinant human Carbonic anhydrase 5A assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	7.2	pKi	63.1	nM	Ki	J Med Chem (2017) 60: 3154-3164 [PMID:28272885]
ChEMBL	Inhibition of human full length carbonic anhydrase 5A by stopped flow CO2 hydrase assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA5A by stopped flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human mitochondrial carbonic anhydrase 5A by stopped flow CO2 hydration method	B	7.2	pKi	63	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human cloned CA5A by stopped-flow CO2 hydration method	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 5A by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 5A by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human recombinant full length mitochondrial carbonic anhydrase 5A by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2009) 17: 4894-4899 [PMID:19539481]
ChEMBL	Inhibition of human full length mitochondrial carbonic anhydrase 5A after 15 mins by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human recombinant CA5A by stopped flow CO2 hydrase assay	B	7.2	pKi	63	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human CA5A by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of full length human carbonic anhydrase 5a preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 5a after 15 mins by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration method	B	7.2	pKi	63	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of human carbonic anhydrase VA by spectrophotometry at pH 7.5	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL	Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 5a preincubated for 15 mins by CO2 hydration method	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human carbonic anhydrase 5A preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human carbonic anhydrase-5A preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2013) 21: 2925-2931 [PMID:23623256]
ChEMBL	Inhibition of human mitochondrial CA5A preincubated for 15 mins by stopped-flow CO2 hydration method	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 5A pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of carbonic anhydrase-5A (unknown origin)	B	7.2	pKi	63	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human CA5A by stopped-flow CO2 hydrase assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of human carbonic anhydrase 5A after 15 mins by stopped flow carbon dioxide hydration assay	B	7.2	pKi	63	nM	Ki	ACS Med Chem Lett (2018) 9: 462-467 [PMID:29795760]
ChEMBL	Inhibition of recombinant human CA5a preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 5a incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Eur J Med Chem (2018) 157: 1214-1222 [PMID:30193219]
ChEMBL	Inhibition of human carbonic anhydrase 5A incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of recombinant human carbonic anhydrase VA preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Eur J Med Chem (2019) 181: 111565-111565 [PMID:31387062]
ChEMBL	Inhibition of human CA5A pre-incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.2	pKi	63	nM	Ki	J Med Chem (2020) 63: 7392-7409 [PMID:32463228]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 5A preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 5A assessed as inhibition constant incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	J Med Chem (2023) 66: 10010-10026 [PMID:37436184]
ChEMBL	Inhibition of human cloned CA5A by stopped-flow CO2 hydration method	B	7.2	pKi	63	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human mitochondrail isozyme CA VA	B	7.2	pKi	63	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human recombinant CA5A after 15 mins by CO2 hydration stopped flow assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2007) 17: 2685-2691 [PMID:17376683]
ChEMBL	Inhibition of human carbonic anhydrase 5A	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibitory activity against human recombinant mitochondrial isozyme CA VA	B	7.2	pKi	63	nM	Ki	J Med Chem (2005) 48: 7860-7866 [PMID:16302824]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 5A by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2021) 49: 128309-128309 [PMID:34371130]
ChEMBL	Inhibition of human carbonic anhydrase 5A by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	J Med Chem (2021) 64: 11432-11444 [PMID:34283610]
ChEMBL	Binding affinity to human recombinant CA5A assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human recombinant CA5A assessed as inhibition constant pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	J Med Chem (2022) 65: 13946-13966 [PMID:36201615]
ChEMBL	Inhibition of recombinant human mitochondrial isozyme CA VA	B	7.22	pKi	60	nM	Ki	Bioorg Med Chem Lett (2005) 15: 5192-5196 [PMID:16203142]
ChEMBL	Inhibition of human carbonic anhydrase 5A using p-nitrophenyl acetate as substrate by UV-VIS spectrophotometric analysis	B	7.16	pIC50	69	nM	IC50	Bioorg Med Chem (2020) 28: 115424-115424 [PMID:32209296]
Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0]
ChEMBL	Inhibition of human carbonic anhydrase 5B at pH7 and 37 degC by fluorescent thermal shift assay	B	6.51	pKd	310	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5B (40 to 317 residues) expressed in Escherichia coli Rosetta 2 (DE3) in presence of ANS by fluorescent thermal shift assay	B	6.51	pKd	310	nM	Kd	Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	6.85	pKd	140	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5B (40 to 317 residues) expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant in presence of ANS by fluorescent thermal shift assay	B	7.11	pKd	77.2	nM	Kd	Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	7.47	pKd	34	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of full length human recombinant mitochondrial carbonic anhydrase 5B preincubated for 15 mins by stopped-flow CO2 hydration assay	B	4.27	pKi	54000	nM	Ki	Bioorg Med Chem Lett (2008) 18: 6332-6335 [PMID:18990571]
ChEMBL	Inhibition of recombinant human Carbonic anhydrase 5B assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	7.27	pKi	54.2	nM	Ki	J Med Chem (2017) 60: 3154-3164 [PMID:28272885]
ChEMBL	Inhibition of human mitochondrail isozyme CA VB	B	7.27	pKi	54	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human carbonic anhydrase 5B	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 5B by stopped flow CO2 hydrase assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA5B by stopped flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human mitochondrial carbonic anhydrase 5B by stopped flow CO2 hydration method	B	7.27	pKi	54	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human cloned CA5B by stopped-flow CO2 hydration method	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 5B by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 5B by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human recombinant full length mitochondrial carbonic anhydrase 5B by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem (2009) 17: 4894-4899 [PMID:19539481]
ChEMBL	Inhibition of human full length mitochondrial carbonic anhydrase 5B after 15 mins by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human recombinant CA5B by stopped flow CO2 hydrase assay	B	7.27	pKi	54	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human CA5B by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of full length human carbonic anhydrase 5b preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 5b after 15 mins by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration method	B	7.27	pKi	54	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 5b preincubated for 15 mins by CO2 hydration method	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human carbonic anhydrase 5B preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of carbonic anhydrase-5B (unknown origin)	B	7.27	pKi	54	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human CA5B by stopped-flow CO2 hydrase assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of human carbonic anhydrase 5B after 15 mins by stopped flow carbon dioxide hydration assay	B	7.27	pKi	54	nM	Ki	ACS Med Chem Lett (2018) 9: 462-467 [PMID:29795760]
ChEMBL	Inhibition of recombinant human CA5b preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 5b incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Eur J Med Chem (2018) 157: 1214-1222 [PMID:30193219]
ChEMBL	Inhibition of human carbonic anhydrase 5B incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of human CA5B pre-incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.27	pKi	54	nM	Ki	J Med Chem (2020) 63: 7392-7409 [PMID:32463228]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 5B preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 5B assessed as inhibition constant incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	J Med Chem (2023) 66: 10010-10026 [PMID:37436184]
ChEMBL	Inhibition of human cloned CA5B by stopped-flow CO2 hydration method	B	7.27	pKi	54	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibitory activity against human recombinant mitochondrial isozyme CA VB	B	7.27	pKi	54	nM	Ki	J Med Chem (2005) 48: 7860-7866 [PMID:16302824]
ChEMBL	Inhibition of human carbonic anhydrase 5B by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	J Med Chem (2021) 64: 11432-11444 [PMID:34283610]
ChEMBL	Inhibition of human recombinant CA5B assessed as inhibition constant pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	J Med Chem (2022) 65: 13946-13966 [PMID:36201615]
ChEMBL	Inhibition of human CAH5B expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	7.61	pKi	24.6	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
ChEMBL	Inhibition of human carbonic anhydrase 6 at pH7 and 37 degC by fluorescent thermal shift assay	B	6.51	pKd	310	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 6 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	6.66	pKd	220	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 6 expressed in Escherichia coli Rosetta2 (DE3) by thermal shift assay	B	6.74	pKd	180	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 6 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	8.01	pKd	9.8	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human CA6 using 4-nitrophenylacetate substrate by esterase assay	B	6.47	pKi	340	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522]
ChEMBL	Inhibition of human carbonic anhydrase 6 esterase activity using 4-nitrophenylacetate as substrate	B	6.47	pKi	340	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL	Inhibition of human carbonic anhydrase 6 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	6.47	pKi	340	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
ChEMBL	Inhibition of human CAH6 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	7.01	pKi	98.2	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay	B	7.96	pKi	11	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human cloned CA6 by stopped-flow CO2 hydration method	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 6 by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human full length carbonic anhydrase 6 after 15 mins by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human recombinant CA6 by stopped flow CO2 hydrase assay	B	7.96	pKi	11	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human CA6 by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of human carbonic anhydrase 6 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 6 after 15 mins by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration method	B	7.96	pKi	11	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of full length human recombinant CA VI	B	7.96	pKi	11	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 6 preincubated for 15 mins by CO2 hydration method	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human carbonic anhydrase 6 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human carbonic anhydrase6 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602]
ChEMBL	Inhibition of human CA6 preincubated for 15 mins by stopped-flow CO2 hydration method	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 6 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of carbonic anhydrase-6 (unknown origin)	B	7.96	pKi	11	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 6 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human CA6 by stopped-flow CO2 hydrase assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of recombinant human CA6 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of human carbonic anhydrase 6 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 6 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
ChEMBL	Inhibition of human carbonic anhydrase 6	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 6 by stopped flow CO2 hydrase assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA6 by stopped flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL	Inhibition of human carbonic anhydrase 7 at pH7 and 37 degC by isothermal titration calorimetry	B	7.2	pKd	63	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to human recombinant CA7 at 37 degC and pH 7.0 by thermal shift assay	B	7.77	pKd	17	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 7 by thermal shift assay	B	7.77	pKd	17	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of human carbonic anhydrase 7 at pH7 and 37 degC by fluorescent thermal shift assay	B	7.77	pKd	17	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 7 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	7.89	pKd	13	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 7 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	8.62	pKd	2.4	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human CAH7 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	7.16	pKi	69.2	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.55	pKi	28	nM	Ki	Bioorg Med Chem (2013) 21: 5799-5805 [PMID:23910989]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 incubated for 15 mins by stopped flow CO2 hydrase assay	B	8.22	pKi	6	nM	Ki	ACS Med Chem Lett (2017) 8: 1213-1217 [PMID:29259736]
ChEMBL	Inhibition of recombinant human CA7 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Eur J Med Chem (2019) 182: 111600-111600 [PMID:31419777]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Eur J Med Chem (2021) 209: 112875-112875 [PMID:33059188]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	ACS Med Chem Lett (2017) 8: 1105-1109 [PMID:29057059]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 7 pretreated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2017) 25: 2518-2523 [PMID:28302505]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2023) 66: 10558-10578 [PMID:37501287]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-7 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 3567-3573 [PMID:28522267]
ChEMBL	Inhibition of recombinant human CA7 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.52	pKi	3	nM	Ki	Eur J Med Chem (2020) 185: 111811-111811 [PMID:31693947]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 using carbon-dioxide as substrate preincubated for 10 mins prior to substrate addition by stopped flow cytometry	B	8.55	pKi	2.8	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1560-1564 [PMID:22277279]
ChEMBL	Inhibition of S-glutathionylated form of human recombinant carbonic anhydrase 7 using carbon-dioxide as substrate preincubated for 10 mins prior to substrate addition by stopped flow cytometry	B	8.57	pKi	2.7	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1560-1564 [PMID:22277279]
GtoPdb	-	-	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-81 [PMID:20605094]
ChEMBL	Inhibition of human recombinant CA7 by stopped flow CO2 hydrase assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human CA7 by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of full length human carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 after 15 mins by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of human recombinant CAH7	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2011) 54: 2522-2526 [PMID:21395315]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 by stopped flow CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3170-3173 [PMID:19435663]
ChEMBL	Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2011) 54: 3977-3981 [PMID:21506569]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2011) 19: 3732-3738 [PMID:21620713]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human carbonic anhydrase 7 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human recombinant full length CA7-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2012) 55: 3891-3899 [PMID:22443141]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human carbonic anhydrase7 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human CA7 preincubated for 15 mins by stopped-flow CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of human recombinant CA-7 after 15 mins by stopped-flow CO2 hydrase assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2015) 23: 1828-1840 [PMID:25766630]
ChEMBL	Inhibition of carbonic anhydrase-7 (unknown origin)	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2015) 23: 7219-7225 [PMID:26498393]
ChEMBL	Inhibition of human carbonic anhydrase-7 preincubated for 15 mins by stopped flow CO2 dehydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2016) 24: 20-25 [PMID:26678172]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2016) 24: 894-901 [PMID:26795114]
ChEMBL	Inhibition of human recombinant membrane bound CA7 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2016) 24: 3548-3555 [PMID:27298005]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 expressed in Escherichia coli assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2017) 27: 86-89 [PMID:27876475]
ChEMBL	Ki value against human carbonic anhydrase VII	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 assessed as reduction in CO2 hydration preincubated for 15 mins by stopped flow assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2017) 25: 1456-1464 [PMID:28111158]
ChEMBL	Inhibition of recombinant human CA7 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2017) 60: 1159-1170 [PMID:28075587]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2017) 127: 521-530 [PMID:28109946]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-7 assessed as reduction in enzyme-catalyzed hydration activity using CO2 as substrate preincubated for 15 mins followed substrate addition measured after 10 to 100 sec by phenol red dye based stopped flow assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2017) 25: 1914-1925 [PMID:28237553]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2017) 60: 2456-2469 [PMID:28253618]
ChEMBL	Inhibition of human carbonic anhydrase 7 incubated for 10 mins by stopped flow CO2 hydrase assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2017) 25: 3093-3097 [PMID:28400084]
ChEMBL	Inhibition of human carbonic anhydrase 7 after 15 mins by stopped flow carbon dioxide hydration assay	B	8.6	pKi	2.5	nM	Ki	ACS Med Chem Lett (2018) 9: 462-467 [PMID:29795760]
ChEMBL	Inhibition of human carbonic anhydrase 7 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2018) 154: 210-219 [PMID:29803994]
ChEMBL	Inhibition of recombinant human CA7 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 assessed as CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye-based stopped-flow assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2018) 156: 430-443 [PMID:30015076]
ChEMBL	Inhibition of recombinant full length human carbonic anhydrase-7 assessed as reduction in CO2 hydration after 15 mins by phenol red dye based stopped flow assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2019) 163: 443-452 [PMID:30530195]
ChEMBL	Inhibition of human carbonic anhydrase 7 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2019) 181: 111586-111586 [PMID:31401537]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2019) 182: 111642-111642 [PMID:31476557]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 preincubated with enzyme for 1 hr prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2020) 63: 5185-5200 [PMID:32364386]
ChEMBL	Inhibition of human CA7 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	8.6	pKi	2.5	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of human CA7 pre-incubated for 15 mins by stopped flow CO2 hydrase assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2020) 63: 7392-7409 [PMID:32463228]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2018) 61: 3151-3165 [PMID:29566486]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2021) 212: 113035-113035 [PMID:33303238]
ChEMBL	Inhibition of recombinant human CA7 preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2021) 45: 128147-128147 [PMID:34052322]
ChEMBL	Inhibition of recombinant human CA7 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2021) 44: 116279-116279 [PMID:34216985]
ChEMBL	Inhibition of recombinant human CA7 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2021) 64: 3100-3114 [PMID:33721499]
ChEMBL	Inhibition of recombinant human CA7 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2021) 225: 113793-113793 [PMID:34507012]
ChEMBL	Inhibition of human carbonic anhydrase 7 by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2021) 64: 11432-11444 [PMID:34283610]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 assessed as inhibition constant preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2022) 227: 113956-113956 [PMID:34731762]
ChEMBL	Binding affinity to human CA7 assessed as inhibition constant	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2020) 28: 115813-115813 [PMID:33069128]
ChEMBL	Inhibition of human CA7 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2023) 66: 1616-1633 [PMID:36626645]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 7 assessed as inhibition constant incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2023) 66: 10010-10026 [PMID:37436184]
ChEMBL	Inhibition of recombinant human carbonic anhydrase VII assessed as inhibition constant incubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2023) 66: 8118-8129 [PMID:37283561]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-7 using CO2 as substrate preincubated for 10 mins by stopped-flow CO2 hydrase assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2017) 25: 539-544 [PMID:27919611]
ChEMBL	Inhibition of human cloned CA7 by stopped-flow CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human recombinant CA7 after 15 mins by CO2 hydration stopped flow assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2007) 17: 2685-2691 [PMID:17376683]
ChEMBL	Inhibition of human carbonic anhydrase 7	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 7 by stopped flow CO2 hydrase assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA7 by stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human cloned CA7 by stopped-flow CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 7 by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 7 by CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2008) 43: 2853-2860 [PMID:18406497]
ChEMBL	Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human full length cytosolic carbonic anhydrase 7 after 15 mins by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human CA7 by stopped-flow CO2 hydrase assay	B	8.7	pKi	2	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 phosphatase activity using 4-nitrophenyl phosphate as substrate preincubated for 10 mins prior to substrate addition by stopped flow cytometry	B	5.46	pIC50	3440	nM	IC50	Bioorg Med Chem Lett (2012) 22: 1560-1564 [PMID:22277279]
ChEMBL	Inhibition of S-glutathionylated form of human recombinant carbonic anhydrase 7 phosphatase activity using 4-nitrophenyl phosphate as substrate preincubated for 10 mins prior to substrate addition by stopped flow cytometry	B	5.6	pIC50	2520	nM	IC50	Bioorg Med Chem Lett (2012) 22: 1560-1564 [PMID:22277279]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 hydrolysis activity using 4-nitrophenyl acetate as substrate preincubated for 10 mins prior to substrate addition by stopped flow cytometry	B	6.45	pIC50	357	nM	IC50	Bioorg Med Chem Lett (2012) 22: 1560-1564 [PMID:22277279]
ChEMBL	Inhibition of S-glutathionylated form of human recombinant carbonic anhydrase 7 hydrolysis activity using 4-nitrophenyl acetate as substrate preincubated for 10 mins prior to substrate addition by stopped flow cytometry	B	6.58	pIC50	265	nM	IC50	Bioorg Med Chem Lett (2012) 22: 1560-1564 [PMID:22277279]
carbonic anhydrase 7/Carbonic anhydrase VII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2216] [GtoPdb: 2749] [UniProtKB: Q9ERQ8]
ChEMBL	Ki value against mouse carbonic anhydrase VII	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL	Inhibition of chimeric carbonic anhydrase 12 (unknown origin) expressing with full length CA2 (1 to 260) at pH7 and 37 degC by fluorescent thermal shift assay	B	6.48	pKd	330	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 12 by thermal shift assay	B	6.88	pKd	133	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Binding affinity to human recombinant CA12 at 37 degC and pH 7.0 by thermal shift assay	B	6.88	pKd	133	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 12 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	6.89	pKd	130	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human carbonic anhydrase 12 at pH7 and 37 degC by fluorescent thermal shift assay	B	6.89	pKd	130	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of human carbonic anhydrase 12 at pH7 and 37 degC by isothermal titration calorimetry	B	6.89	pKd	130	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of human carbonic anhydrase 12 at pH7 and 25 degC by stopped-flow kinetic inhibition assay	B	7.6	pKd	25	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 12 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	7.62	pKd	24	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 assessed as inhibition constant incubated for 1 hr prior to testing by phenol red based stopped-flow CO2 hydration assay	B	5.24	pKi	5700	nM	Ki	Bioorg Med Chem (2022) 67: 116805-116805 [PMID:35635929]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 using 4-nitrophenyl acetate as substrate assessed as inhibition constant by spectrophotometric analysis	B	6.47	pKi	338.9	nM	Ki	Bioorg Med Chem (2023) 77: 117111-117111 [PMID:36463726]
ChEMBL	Inhibition of human CA12	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 4560-4565 [PMID:28728897]
ChEMBL	Inhibition of human carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 dehydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 104-112 [PMID:26682703]
ChEMBL	Inhibition of recombinant human CA12 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2019) 181: 111573-111573 [PMID:31394463]
ChEMBL	Inhibition of human CA12 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem Lett (2012) 22: 5801-5806 [PMID:22901388]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2016) 24: 982-988 [PMID:26803577]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2016) 24: 1095-1105 [PMID:26810710]
ChEMBL	Inhibition of human carbonic anhydrase 12 catalytic domain by Stopped-Flow CO2 Hydrase assay	B	8.22	pKi	6	nM	Ki	J Med Chem (2016) 59: 462-473 [PMID:26688270]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped flow CO2 assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem Lett (2022) 70: 128809-128809 [PMID:35605838]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Eur J Med Chem (2020) 200: 112300-112300 [PMID:32460112]
ChEMBL	Inhibition of recombinant human transmembrane, tumor-associated form of carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem Lett (2015) 25: 2377-2381 [PMID:25913118]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	ACS Med Chem Lett (2020) 11: 1022-1027 [PMID:32435420]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-12 catalytic domain by stopped-flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	ACS Med Chem Lett (2015) 6: 819-821 [PMID:26191373]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 catalytic domain expressed in Escherichia coli incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2015) 23: 6573-6580 [PMID:26422787]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6759-6763 [PMID:24189056]
ChEMBL	Inhibition of human carbonic anhydrase-12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2013) 21: 2925-2931 [PMID:23623256]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 catalytic domain preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	ACS Med Chem Lett (2017) 8: 941-946 [PMID:28947941]
ChEMBL	Inhibition of human recombinant CA12 expressed in Escherichia coli by stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	J Med Chem (2015) 58: 6630-6638 [PMID:26203869]
ChEMBL	Inhibition of human CA12 by stopped-flow CO2 hydrase assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydrase assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2014) 22: 1821-1831 [PMID:24560739]
ChEMBL	Inhibition of human CA12 by Lineweaver-Burk plot analysis	B	8.22	pKi	6	nM	Ki	ACS Med Chem Lett (2018) 9: 1045-1050 [PMID:30344915]
ChEMBL	Inhibition of human CA12 by stopped-flow CO2 hydration method	B	8.22	pKi	6	nM	Ki	J Med Chem (2015) 58: 640-650 [PMID:25432060]
ChEMBL	Inhibition of recombinant human carbonic anhydrase12 preincubated for 10 mins followed by CO2 solution addition by phenol red dye based stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2019) 27: 115090-115090 [PMID:31515058]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli preincubated for 15 mins by stopped flow CO2 hydration method	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2015) 23: 4649-4659 [PMID:26088336]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.8	nM	Ki	ACS Med Chem Lett (2014) 5: 793-796 [PMID:25050167]
ChEMBL	Inhibition of human carbonic anhydrase-12 pre-incubated for 15 mins by stopped-flow CO2 hydration assay based Lineweaver-Burk plot method	B	8.24	pKi	5.8	nM	Ki	Bioorg Med Chem (2015) 23: 3674-3680 [PMID:25921266]
ChEMBL	Inhibition of human carbonic anhydrase 12 by by stopped flow CO2 hydration method	B	8.24	pKi	5.8	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.8	nM	Ki	J Med Chem (2022) 65: 824-837 [PMID:34958217]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration assay	B	8.24	pKi	5.8	nM	Ki	Bioorg Med Chem (2015) 23: 1421-1429 [PMID:25757603]
ChEMBL	Inhibition of human carbonic anhydrase 12-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	8.24	pKi	5.8	nM	Ki	Bioorg Med Chem (2014) 22: 2643-2647 [PMID:24713308]
GtoPdb	-	-	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-9 [PMID:15686894]; Bioorg Med Chem Lett (2010) 20: 4376-81 [PMID:20605094]
ChEMBL	Inhibition of human cloned catalytic domain of CA12 after 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of human carbonic anhydrase XII by spectrophotometry at pH 7.5	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL	Inhibition of tumor-associated human carbonic anhydrase 12 preincubated for 15 min by CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain by CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3216-3221 [PMID:21549597]
ChEMBL	Inhibition of human recombinant catalytic domain of carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2975-2979 [PMID:21470859]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human recombinant CA12 by CO2 hydration based stopped flow assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2011) 54: 6905-6918 [PMID:21851094]
ChEMBL	Inhibition of human carbonic anhydrase 12-catalyzed CO2 hydration activity by stopped flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5892-5896 [PMID:21852133]
ChEMBL	Inhibition of human carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2012) 20: 2392-2404 [PMID:22370338]
ChEMBL	Inhibition of human CA12 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2012) 55: 1721-1730 [PMID:22276570]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human CA12 by stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2013) 23: 715-719 [PMID:23265898]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2013) 21: 1396-1403 [PMID:23290254]
ChEMBL	Inhibition of recombinant human CA12 transmembrane isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2013) 56: 4691-4700 [PMID:23647428]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2013) 21: 3949-3957 [PMID:23706268]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 after 6 hrs by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2013) 21: 4502-4510 [PMID:23769167]
ChEMBL	Inhibition of human membrane bound carbonic anhydrase 12 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human carbonic anhydrase-12 by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2013) 23: 5646-5649 [PMID:23993330]
ChEMBL	Inhibition of human carbonic anhydrase12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2013) 56: 9623-9634 [PMID:24200125]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human CA12 after 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human recombinant transmembrane carbonic anhydrase 12 after 6 hrs by stopped flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 1522-1528 [PMID:24513186]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 1873-1882 [PMID:24560737]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
ChEMBL	Inhibition of human carbonic anhydrase 12-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2014) 76: 284-290 [PMID:24589484]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12-mediated CO2 hydration after 6 hrs by stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1256-1260 [PMID:24518190]
ChEMBL	Inhibition of human recombinant transmembrane tumor associated carbonic anhydrase-12 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1776-1779 [PMID:24589511]
ChEMBL	Inhibition of human cloned transmembrane tumor-associated catalytic domain of carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 3684-3695 [PMID:24878360]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydrase assay method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 6945-6952 [PMID:25456084]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 after 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 by stopped flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2014) 84: 240-246 [PMID:25019479]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydrase Assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2014) 5: 927-930 [PMID:25147616]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2014) 24: 5185-5189 [PMID:25442309]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2014) 57: 9152-9167 [PMID:25310626]
ChEMBL	Inhibition of human CA-12 by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2014) 57: 9673-9686 [PMID:25358036]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2014) 87: 186-196 [PMID:25255434]
ChEMBL	Inhibition of human CA-12 after 15 mins by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 5883-5890 [PMID:25267005]
ChEMBL	Inhibition of human tumor-associated carbonic anhydrase 12 by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 1430-1436 [PMID:25753329]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 2368-2376 [PMID:25846066]
ChEMBL	Inhibition of human recombinant CA-12 after 15 mins by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 1828-1840 [PMID:25766630]
ChEMBL	Inhibition of human membrane associated form of carbonic anhydrase-12 assessed as CO2 hydration activity incubated for 15 mins prior to testing by stopped flow method	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2015) 96: 425-435 [PMID:25912674]
ChEMBL	Inhibition of human recombinant carbonic anhdydrase-12 expressed in Escherichia coli pre-incubated for 6 hrs by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2015) 58: 3975-3983 [PMID:25875209]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of human carbonic anhydrase-12 incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3208-3212 [PMID:26105196]
ChEMBL	Inhibition of human carbonic anhydrase-12	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3281-3284 [PMID:26073006]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-12 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 5619-5625 [PMID:26233796]
ChEMBL	Inhibition of human carbonic anhydrase-12 incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
ChEMBL	Inhibition of carbonic anhydrase-12 (unknown origin)	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 6 hrs by stopped flow carbon-di-oxide hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 6955-6966 [PMID:26432607]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 7219-7225 [PMID:26498393]
ChEMBL	Inhibition of human carbonic anhydrase-12 assessed as CO2 hydration activity by stopped-flow method	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2015) 58: 8564-8572 [PMID:26497049]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli preincubated for 6 hrs by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2015) 103: 583-593 [PMID:26408817]
ChEMBL	Inhibition of human carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 dehydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 20-25 [PMID:26678172]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 894-901 [PMID:26795114]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by CO2 hydration-based stopped flow assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2016) 59: 721-732 [PMID:26741028]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 1402-1407 [PMID:26875933]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow carbon dioxide hydrase assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2016) 110: 259-266 [PMID:26840366]
ChEMBL	Inhibition of human carbonic anhydrase 12 using saturated CO2 as substrate incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 2882-2886 [PMID:27137360]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 min to 72 hrs by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 2907-2913 [PMID:27166574]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 3643-3648 [PMID:27316543]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2016) 59: 5077-5088 [PMID:27144971]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 4100-4107 [PMID:27396930]
ChEMBL	Inhibition of human carbonic anhydrase 12 pre-incubated for 15 mins by stopped flow carbon dioxide hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2016) 59: 10692-10704 [PMID:27933963]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-12 preincubated for 6 hrs by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 677-683 [PMID:27939347]
ChEMBL	Inhibition of recombinant human membrane bound carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 1286-1293 [PMID:28065499]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 12 after 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2017) 127: 691-702 [PMID:27823879]
ChEMBL	Inhibition of recombinant human CA12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2017) 60: 1159-1170 [PMID:28075587]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2017) 60: 2456-2469 [PMID:28253618]
ChEMBL	Binding affinity to human recombinant CA12 assessed as inhibition constant incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2023) 66: 14824-14842 [PMID:37902628]
ChEMBL	Inhibitory activity against catalytic domain of human carbonic anhydrase XII	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853]
ChEMBL	Ki value against human carbonic anhydrase XII (hCA XII)	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894]
ChEMBL	Inhibition constant against human carbonic anhydrase XII	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against human Carbonic anhydrase XII (hCA XII)	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibitory activity against cloned human CA12	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146]
ChEMBL	Inhibition of human cloned CA12 catalytic domain by CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of catalytic domain of human cloned CA12 by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of catalytic domain of human CA XII	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human recombinant CA12 by CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2007) 17: 987-992 [PMID:17157501]
ChEMBL	Inhibition of human carbonic anhydrase 12	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant CA12 by CO2 hydration stopped flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of human catalytic domain carbonic anhydrase 12 by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant CA12 by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human cloned CA12 catalytic domain by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 12 catalytic domain by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 12 by CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2008) 43: 2853-2860 [PMID:18406497]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human membrane-bound carbonic anhydrase 12 catalytic domain after 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human cloned CA12 catalytic domain by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2009) 52: 6421-6432 [PMID:19827837]
ChEMBL	Inhibition of human recombinant CA12 by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5825-5828 [PMID:19751975]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain expressed in Sf9 cells by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2009) 17: 7093-7099 [PMID:19773173]
ChEMBL	Inhibition of human CA12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of human recombinant CA12 by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2010) 53: 2913-2926 [PMID:20201556]
ChEMBL	Inhibition of human carbonic anhydrase 12 catalytic domain preincubated for 15 mins by CO2 hydration stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 after 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2022) 228: 114004-114004 [PMID:34847409]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by phenol red based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2022) 228: 113997-113997 [PMID:34902732]
ChEMBL	Binding affinity to human CA12 assessed as inhibition constant by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of recombinant human CA12 pre-incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2022) 65: 13143-13157 [PMID:36121705]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2022) 238: 114412-114412 [PMID:35551035]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2022) 59: 128581-128581 [PMID:35066141]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 assessed as inhibition constant incubated for 10 mins by phenol red dye based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2022) 234: 114247-114247 [PMID:35305463]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 assessed as inhibition constant preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2022) 227: 113956-113956 [PMID:34731762]
ChEMBL	Inhibition of recombinant human CA 12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2022) 232: 114190-114190 [PMID:35182815]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 10 mins and measured by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2022) 65: 14655-14672 [PMID:36269278]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2023) 14: 810-819 [PMID:37312840]
ChEMBL	Inhibition of human CA12	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibition constant	B	8.24	pKi	5.7	nM	Ki	RSC Med Chem (2023) 14: 144-153 [PMID:36760748]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2023) 66: 1616-1633 [PMID:36626645]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 12 assessed as inhibition constant incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2023) 66: 10010-10026 [PMID:37436184]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibition constant incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2024) 67: 3018-3038 [PMID:38301036]
ChEMBL	Inhibition of human human carbonic anhydrase XII assessed as inhibition constant incubated for 15 min by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2024) 15: 470-477 [PMID:38628786]
ChEMBL	Inhibition of recombinant human CA XII (30 to 291 residues) expressed in escherichia coli BL21 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2023) 66: 5703-5718 [PMID:37022308]
ChEMBL	Binding affinity to human CA12 assessed as inhibition constant incubated for 6 hrs by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2023) 246: 115011-115011 [PMID:36516582]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibition constant incubated for 1 hr prior to testing by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2023) 14: 1067-1072 [PMID:37583824]
ChEMBL	Inhibition of human CA XII assessed as inhibition constant by stopped-flow CO2 hydrase assay method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2023) 95: 129479-129479 [PMID:37704010]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibition constant preincubated for 15 mins and measured by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2023) 94: 117467-117467 [PMID:37722299]
ChEMBL	Binding affinity to human CA12 assessed as inhibition constant by stopped flow kinetic assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2023) 250: 115180-115180 [PMID:36796297]
ChEMBL	Inhibitory constant against catalytic domain of human carbonic anhydrase XII	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 2782-2788 [PMID:28389112]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2017) 60: 9003-9011 [PMID:29048889]
ChEMBL	Inhibition of human CA12 pre-incubated for 10 mins by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 5373-5379 [PMID:28789908]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-12 preincubated for 10 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 5726-5732 [PMID:28887000]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 assessed as reduction in CO2 hydration pretreated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2017) 8: 792-796 [PMID:28835790]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2018) 143: 1931-1941 [PMID:29146134]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2018) 143: 276-282 [PMID:29197732]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2018) 61: 5380-5394 [PMID:29851481]
ChEMBL	Binding affinity to human carbonic anhydrase 12 by stopped flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2018) 9: 725-729 [PMID:30034608]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-12 incubated for 15 mins by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2018) 61: 4961-4977 [PMID:29746127]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated 15 mins prior to testing by CO2 hydration based stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2018) 9: 947-951 [PMID:30258546]
ChEMBL	Inhibition of human CA12 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2018) 61: 6328-6338 [PMID:29962205]
ChEMBL	Inhibition of recombinant human CA12 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2018) 157: 28-36 [PMID:30071407]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 10 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 183: 111702-111702 [PMID:31542715]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 184: 111768-111768 [PMID:31629164]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-12 incubated for 15 mins by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 185: 111843-111843 [PMID:31718943]
ChEMBL	Inhibition of human carbonic anhydrase-12 catalytic domain assessed as reduction in CO2 hydration after 15 mins by phenol red dye based stopped flow assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 163: 443-452 [PMID:30530195]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 expressed in Escherichia coli by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2019) 62: 4174-4192 [PMID:30925064]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2019) 10: 661-665 [PMID:30996814]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 179: 547-556 [PMID:31276899]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2020) 63: 2470-2488 [PMID:31972093]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2019) 62: 7233-7249 [PMID:31287314]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibitory constant incubated for 15 mins by phenol red dye based stopped flow assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 182: 111638-111638 [PMID:31472471]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins by phenol red staining-based stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2019) 27: 115086-115086 [PMID:31515057]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 1 hr prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2020) 63: 321-333 [PMID:31794211]
ChEMBL	Inhibition of human CA 12 catalytic domain	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 168: 301-314 [PMID:30826507]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibitory constant preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 175: 40-48 [PMID:31071549]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2019) 27: 1588-1594 [PMID:30846402]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as reduction in CO2 hydration after 15 mins by phenol red staining-based stopped flow assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 164: 92-105 [PMID:30594030]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2016) 59: 5857-5867 [PMID:27253845]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2016) 26: 3892-3895 [PMID:27423482]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of human CA12 pre-incubated for 15 mins by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2020) 63: 7392-7409 [PMID:32463228]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2020) 11: 852-856 [PMID:32435395]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by stopped-flow CO2 hydration kinetic assay based Cheng-Prusoff equation analysis	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2020) 63: 7422-7444 [PMID:32519851]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibitory constant incubated for 6 hrs by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2020) 28: 115496-115496 [PMID:32327349]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2020) 28: 115329-115329 [PMID:32007388]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 188: 112021-112021 [PMID:31901743]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 189: 112019-112019 [PMID:31972394]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 10 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 193: 112219-112219 [PMID:32203788]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 200: 112449-112449 [PMID:32485534]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 207: 112745-112745 [PMID:32877804]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2021) 209: 112897-112897 [PMID:33038795]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2021) 212: 113035-113035 [PMID:33303238]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 assessed as inhibition constant preincubated with enzyme for 10 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2020) 28: 115586-115586 [PMID:32631564]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 10 mins by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2021) 39: 127877-127877 [PMID:33640442]
ChEMBL	Inhibition of recombinant human CA12 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 190: 112112-112112 [PMID:32044580]
ChEMBL	Inhibition of human CA12 by stopped-flow carbon dioxide hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 200: 112439-112439 [PMID:32485532]
ChEMBL	Inhibition of human CA12 measured by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2021) 48: 128249-128249 [PMID:34237441]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2021) 49: 128309-128309 [PMID:34371130]
ChEMBL	Inhibition of recombinant human CA12 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2021) 218: 113360-113360 [PMID:33773285]
ChEMBL	Inhibition of recombinant human CA12 pre-incubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2021) 218: 113352-113352 [PMID:33774343]
ChEMBL	Inhibition of full length human CA12 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2021) 44: 116279-116279 [PMID:34216985]
ChEMBL	Inhibition of human CA12 by stopped- flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2021) 216: 113283-113283 [PMID:33667848]
ChEMBL	Inhibition of recombinant human CA12 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2021) 64: 3100-3114 [PMID:33721499]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2021) 222: 113589-113589 [PMID:34147910]
ChEMBL	Inhibition of human CA12 measured after 15 mins by stopped flow carbon dioxide anhydrase assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2021) 225: 113800-113800 [PMID:34482273]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2021) 64: 11432-11444 [PMID:34283610]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2016) 24: 921-927 [PMID:26796953]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-12-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2013) 21: 1386-1391 [PMID:23352754]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2017) 25: 2569-2576 [PMID:28347633]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-12 assessed as reduction in CO2 hydration preincubated for 10 mins measured for 5 to 10 secs by stopped flow assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2017) 25: 3583-3589 [PMID:28416101]
ChEMBL	Inhibition of recombinant human Carbonic anhydrase 12 assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	8.25	pKi	5.6	nM	Ki	J Med Chem (2017) 60: 3154-3164 [PMID:28272885]
ChEMBL	Inhibition of recombinant human catalytic domain of carbonic anhydrase-12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	J Med Chem (2013) 56: 8512-8520 [PMID:24128000]
ChEMBL	Inhibition of human recombinant transmembrane tumor associated carbonic anhydrase 12 preincubated for 10 mins prior to testing by stopped-flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2017) 25: 857-863 [PMID:28024887]
ChEMBL	Inhibition of human carbonic anhydrase 12 for 15 mins by stopped flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2016) 24: 976-981 [PMID:26810836]
ChEMBL	Inhibition of human CA12 incubated for 15 mins by stopped- flow CO2 hydrase assay method	B	8.25	pKi	5.6	nM	Ki	Eur J Med Chem (2020) 201: 112478-112478 [PMID:32659606]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 by stopped flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Eur J Med Chem (2019) 162: 147-160 [PMID:30445264]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2013) 21: 5130-5138 [PMID:23859774]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Eur J Med Chem (2022) 228: 114008-114008 [PMID:34871842]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration method	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3850-3853 [PMID:26233435]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 10 mins by CO2 hydration stopped-flow assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2013) 21: 5228-5232 [PMID:23842519]
ChEMBL	Inhibition of human CA12 after 15 mins by stopped-flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Eur J Med Chem (2018) 146: 47-59 [PMID:29407972]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	J Med Chem (2017) 60: 6428-6439 [PMID:28658574]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain by stopped flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2014) 22: 6353-6359 [PMID:25438758]
ChEMBL	Inhibition of human recombinant transmembrane CA12 catalytic domain after 6 hrs by stopped-flow CO2 hydration method	B	8.3	pKi	5	nM	Ki	J Med Chem (2013) 56: 293-300 [PMID:23241068]
ChEMBL	Binding affinity to human recombinant CA12 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	8.3	pKi	5	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human CAH12 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	8.32	pKi	4.8	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of carbonic anhydrase 12 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.52	pKi	3	nM	Ki	J Med Chem (2018) 61: 10860-10874 [PMID:30433782]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 catalytic domain preincubated for 15 mins by CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2010) 18: 4873-4878 [PMID:20598552]
ChEMBL	Inhibition of tumor-associated transmembrane human carbonic anhydrase-12 after 15 mins by Stopped-flow CO2 hydrase assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2013) 21: 2314-2318 [PMID:23490152]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as reduction in CO2 hydration preincubated for 15 mins to 2 hrs by phenol red dye based stopped flow CO2 hydrase assay	B	8.6	pKi	2.5	nM	Ki	ACS Med Chem Lett (2019) 10: 1205-1210 [PMID:31413806]
ChEMBL	Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 30 mins by colorimetric analysis	B	5.81	pIC50	1550	nM	IC50	Bioorg Med Chem (2019) 27: 3889-3901 [PMID:31345748]
ChEMBL	Inhibition of Carbonic anhydrase 12 (unknown origin) using p-nitrophenyl acetate as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by microplate reader method	B	5.81	pIC50	1550	nM	IC50	Eur J Med Chem (2023) 246: 114958-114958 [PMID:36470105]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 pretreated for 15 mins by stopped flow CO2 hydrase assay	B	7.06	pIC50	88	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2617-2620 [PMID:24813742]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.21	pIC50	61	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1941-1943 [PMID:24650641]
ChEMBL	Inhibition of CA-12 (unknown origin) after 15 mins by CO2 hydration assay	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem Lett (2014) 24: 3422-3425 [PMID:24948563]
ChEMBL	Inhibition of human recombinant CA12 incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	8.24	pIC50	5.7	nM	IC50	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
carbonic anhydrase 13/Carbonic anhydrase XIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 13 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	7.1	pKd	79	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 13 by isothermal titration calorimetry assay	B	7.19	pKd	65	nM	Kd	Bioorg Med Chem (2010) 18: 7413-7421 [PMID:20889345]
ChEMBL	Inhibition of human carbonic anhydrase 13 at pH7 and 37 degC by isothermal titration calorimetry	B	7.22	pKd	60	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay	B	7.3	pKd	50	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of human carbonic anhydrase 13 at pH7 and 37 degC by fluorescent thermal shift assay	B	7.3	pKd	50	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay	B	7.3	pKd	50	nM	Kd	Bioorg Med Chem (2010) 18: 7413-7421 [PMID:20889345]
ChEMBL	Binding affinity to human recombinant CA13 at 37 degC and pH 7.0 by thermal shift assay	B	7.3	pKd	50	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human N-terminal full length His-tagged CA13 (1 to 262 residues) expressed in Escherichia coli BL21(DE3) assessed as thermodynamic equilibrium constant at pH 7 by SPR assay	B	7.44	pKd	36.5	nM	Kd	J Med Chem (2018) 61: 2292-2302 [PMID:29466001]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 13 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	7.46	pKd	35	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to human N-terminal full length His-tagged CA13 (1 to 262 residues) expressed in Escherichia coli BL21(DE3) assessed as intrinsic thermodynamic equilibrium constant at pH 7 by SPR assay	B	8	pKd	10	nM	Kd	J Med Chem (2018) 61: 2292-2302 [PMID:29466001]
ChEMBL	Inhibition of human carbonic anhydrase 13 at pH7 and 25 degC by stopped-flow kinetic inhibition assay	B	8	pKd	<10	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of human CAH13 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	7.68	pKi	21.1	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 13 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.74	pKi	18	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 13 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem (2011) 19: 3732-3738 [PMID:21620713]
ChEMBL	Inhibition of human carbonic anhydrase 13 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human carbonic anhydrase13 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602]
ChEMBL	Inhibition of human CA13 preincubated for 15 mins by stopped-flow CO2 hydration method	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human recombinant CA13 by stopped flow CO2 hydrase assay	B	7.77	pKi	17	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of carbonic anhydrase-13 (unknown origin)	B	7.77	pKi	17	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 13 after 15 mins by stopped-flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 13 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 13 by stopped flow CO2 hydrase assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2021) 37: 127856-127856 [PMID:33609663]
ChEMBL	Inhibition of human CA13 by stopped-flow CO2 hydrase assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of recombinant human CA13 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of human carbonic anhydrase 13 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 13 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.79	pKi	16.4	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 13 preincubated for 15 mins by CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
ChEMBL	Inhibitory activity against murine carbonic anhydrase XIII (mCA XIII) by using CO2 hydrase assay method	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2004) 14: 3757-3762 [PMID:15203157]
ChEMBL	Ki value against mouse carbonic anhydrase XIII	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Ki value against mouse carbonic anhydrase XIII	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Inhibition of murine CA13 by stopped-flow CO2 hydration method	B	7.77	pKi	17	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of mouse carbonic anhydrase 13	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of mouse full length carbonic anhydrase 13 by stopped flow CO2 hydrase assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of mouse recombinant full length CA13 by stopped flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of mouse recombinant full length CA13 by stopped-flow CO2 hydration method	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of mouse CA13 by stopped-flow CO2 hydration method	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of mouse carbonic anhydrase 13 by stopped-flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of mouse full length cytosolic carbonic anhydrase 13 after 15 mins by stopped-flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of mouse CA13 by stopped-flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of full length mouse carbonic anhydrase 13 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration method	B	7.77	pKi	17	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
GtoPdb	-	-	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-81 [PMID:20605094]
ChEMBL	Inhibition of mouse carbonic anhydrase 13 assessed as 4-nitrophenyl phosphate hydrolysis	B	5.98	pIC50	1050	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2267-2271 [PMID:18353640]
ChEMBL	Inhibition of mouse carbonic anhydrase 13 assessed as 4-nitrophenyl acetate hydrolysis	B	6.31	pIC50	490	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2267-2271 [PMID:18353640]
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 14 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	7.2	pKd	63	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 14 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	7.92	pKd	12	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human carbonic anhydrase 14 at pH7 and 37 degC by fluorescent thermal shift assay	B	7.96	pKd	11	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of human CAH14 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	6.71	pKi	194.4	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.38	pKi	41.3	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human recombinant CA14 by CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2007) 17: 987-992 [PMID:17157501]
ChEMBL	Inhibition of human recombinant CA14 after 15 mins by CO2 hydration stopped flow assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2007) 17: 2685-2691 [PMID:17376683]
ChEMBL	Inhibition of human carbonic anhydrase 14	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 14 by stopped flow CO2 hydrase assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA14 by stopped flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human cloned CA14 by stopped-flow CO2 hydration method	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 14 by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 14 by CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Eur J Med Chem (2008) 43: 2853-2860 [PMID:18406497]
ChEMBL	Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human full length membrane-bound carbonic anhydrase 14 after 15 mins by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human recombinant CA14 by stopped flow CO2 hydrase assay	B	7.39	pKi	41	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 expressed in Escherichia coli by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5825-5828 [PMID:19751975]
ChEMBL	Inhibition of human CA14 by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of full length human carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human full length carbonic anhydrase 14 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 after 15 mins by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration method	B	7.39	pKi	41	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assay	B	7.39	pKi	41	nM	Ki	J Med Chem (2011) 54: 3977-3981 [PMID:21506569]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration method	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human cloned full length carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human carbonic anhydrase 14 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human full length cloned transmembrane carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2012) 20: 2392-2404 [PMID:22370338]
ChEMBL	Inhibition of human recombinant full length CA14-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	7.39	pKi	41	nM	Ki	J Med Chem (2012) 55: 3891-3899 [PMID:22443141]
ChEMBL	Inhibition of human carbonic anhydrase-14 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2013) 21: 2925-2931 [PMID:23623256]
ChEMBL	Inhibition of human carbonic anhydrase14 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602]
ChEMBL	Inhibition of human carbonic anhydrase 14 by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	J Med Chem (2013) 56: 9623-9634 [PMID:24200125]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human CA14 preincubated for 15 mins by stopped-flow CO2 hydration method	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of carbonic anhydrase-14 (unknown origin)	B	7.39	pKi	41	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human carbonic anhydrase-14 assessed as CO2 hydration activity by stopped-flow method	B	7.39	pKi	41	nM	Ki	J Med Chem (2015) 58: 8564-8572 [PMID:26497049]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 14 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2016) 24: 894-901 [PMID:26795114]
ChEMBL	Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibition of human CA14 by stopped-flow CO2 hydrase assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of recombinant human CA14 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of human carbonic anhydrase-14 catalytic domain assessed as reduction in CO2 hydration after 15 mins by phenol red dye based stopped flow assay	B	7.39	pKi	41	nM	Ki	Eur J Med Chem (2019) 163: 443-452 [PMID:30530195]
ChEMBL	Inhibition of human CA14 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	7.39	pKi	41	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	J Med Chem (2016) 59: 5077-5088 [PMID:27144971]
ChEMBL	Inhibition of human cloned CA14 by stopped-flow CO2 hydration method	B	7.39	pKi	41	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
GtoPdb	-	-	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5427-33 [PMID:15454239]; Bioorg Med Chem Lett (2010) 20: 4376-81 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase-14 preincubated for 15 mins by stopped flow CO2 dehydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 104-112 [PMID:26682703]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 pretreated for 15 mins by stopped flow CO2 hydrase assay	B	6.65	pIC50	224	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2617-2620 [PMID:24813742]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.32	pIC50	48	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1941-1943 [PMID:24650641]
Delta carbonic anhydrase in Thalassiosira weissflogii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1]
ChEMBL	Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.08	pKi	83	nM	Ki	Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394]
Endochitinase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293195] [UniProtKB: P29029]
ChEMBL	Inhibition of Saccharomyces cerevisiae CTS1	B	4.68	pKi	21000	nM	Ki	Bioorg Med Chem (2010) 18: 8334-8340 [PMID:21044846]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Ex vivo inhibition of Plasmodium falciparum growth in cultured cells after 48hrs as [3H]hypoxanthine uptake	F	4.7	pIC50	20000	nM	IC50	Bioorg Med Chem Lett (2008) 18: 5466-5471 [PMID:18805693]
PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5767] [UniProtKB: P96878]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 by stopped flow CO2 hydration assay	B	6.98	pKi	104	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4929-4932 [PMID:19651511]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv3273 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.98	pKi	104	nM	Ki	Bioorg Med Chem Lett (2011) 21: 102-105 [PMID:21145236]
ChEMBL	Inhibition of recombinant Mycobacterium tuberculosis Rv3273 carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay at pH 7.5	B	6.98	pKi	104	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3591-3595 [PMID:21570835]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 at pH 8.3 by stopped flow CO2 hydration assay	B	6.98	pKi	104	nM	Ki	Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant Rv3273 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay	B	7	pKi	100	nM	Ki	J Med Chem (2011) 54: 1682-1692 [PMID:21332115]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 by by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2009) 52: 4063-4067 [PMID:19438226]
Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay	B	6.32	pKi	481	nM	Ki	J Med Chem (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 by stopped flow CO2 hydration assay	B	6.32	pKi	481	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4929-4932 [PMID:19651511]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.32	pKi	481	nM	Ki	Bioorg Med Chem Lett (2011) 21: 102-105 [PMID:21145236]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 at pH 8.3 by stopped flow CO2 hydration assay	B	6.32	pKi	480	nM	Ki	Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL	Inhibition of Mycobacterium tuberculosis beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.32	pKi	480	nM	Ki	Bioorg Med Chem (2016) 24: 4406-4409 [PMID:27469982]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant Rv1284 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay	B	6.32	pKi	480	nM	Ki	J Med Chem (2011) 54: 1682-1692 [PMID:21332115]
ChEMBL	Inhibition of recombinant Mycobacterium tuberculosis Rv1284 carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay at pH 7.5	B	6.32	pKi	480	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3591-3595 [PMID:21570835]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 by by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 4063-4067 [PMID:19438226]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]