Ligand id: 6782

Name: digitoxin

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 13
Hydrogen bond donors 5
Rotatable bonds 7
Topological polar surface area 182.83
Molecular weight 764.43
XLogP 3.42
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Previously used in treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure
Mechanism Of Action and Pharmacodynamic Effects
A cardiac glycoside inhibiting the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations