digitoxin [Ligand Id: 6782] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL254219 (Cristapurat, Crystodigin, CRYSTODIGIN, Digimerck, Digitalin, crystalline, Digitophyllin, Digitoxin, Digitoxina, Digitoxine, Digitoxinum, Digitoxoside, Glucodigin, Lanatoxin, Nativelle digitaline, NSC-7529, Purpurid, Tradigal) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| sodium/potassium-transporting ATPase subunit α-1/sodium/potassium-transporting ATPase subunit β-1/sodium/potassium-transporting ATPase subunit α-3/sodium/potassium-transporting ATPase subunit β-2/sodium/potassium-transporting ATPase subunit α-2/sodium/potassium-transporting ATPase subunit β-3/sodium/potassium-transporting ATPase subunit γ/sodium/potassium-transporting ATPase subunit α-4/Sodium/potassium-transporting ATPase in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095186] [GtoPdb: 833, 837, 835, 838, 834, 839, 2610, 836] [UniProtKB: P05023, P05026, P13637, P14415, P50993, P54709, P54710, Q13733] | ||||||||
| ChEMBL | Inhibition of [3H]- ouabain binding to digitalis receptor | B | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (1993) 36: 42-45 [PMID:8421289] |
| sodium/potassium-transporting ATPase subunit α-1/sodium/potassium-transporting ATPase subunit β-1/sodium/potassium-transporting ATPase subunit α-3/sodium/potassium-transporting ATPase subunit β-2/sodium/potassium-transporting ATPase subunit α-2/sodium/potassium-transporting ATPase subunit β-3/sodium/potassium-transporting ATPase subunit γ/sodium/potassium-transporting ATPase subunit α-4 in Dog [GtoPdb: 833, 837, 835, 838, 834, 839, 2610, 836] | ||||||||
| GtoPdb | - | - | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (1993) 36: 42-5 [PMID:8421289] |
| Sodium/potassium-transporting ATPase alpha-1 chain in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4838] [UniProtKB: P50997] | ||||||||
| ChEMBL | Inhibition of [3H]ouabain binding to Digitalis receptor in dog heart microsomes | B | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (1997) 40: 1439-1446 [PMID:9154966] |
| OATP4C1/Solute carrier organic anion transporter family member 4C1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073690] [GtoPdb: 1227] [UniProtKB: Q6ZQN7] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of Digoxin uptake in OATP4C1-expressing MDCK cells | F | 6.92 | pIC50 | 120 | nM | IC50 | Proc Natl Acad Sci U S A (2004) 101: 3569-3574 [PMID:14993604] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
