digitoxin [Ligand Id: 6782] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL254219 (Digimerck, Digitoxin, Nativelle Digitaline, Crystodigin, Digitoxoside)
  • sodium/potassium-transporting ATPase subunit α-1/sodium/potassium-transporting ATPase subunit β-1/sodium/potassium-transporting ATPase subunit α-3/sodium/potassium-transporting ATPase subunit β-2/sodium/potassium-transporting ATPase subunit α-2/sodium/potassium-transporting ATPase subunit β-3/sodium/potassium-transporting ATPase subunit γ/sodium/potassium-transporting ATPase subunit α-4/Sodium/potassium-transporting ATPase in Human [ChEMBL: CHEMBL2095186] [GtoPdb: 8338378358388348392610836] [UniProtKB: P05023P05026P13637P14415P50993P54709P54710Q13733]
  • sodium/potassium-transporting ATPase subunit α-1/sodium/potassium-transporting ATPase subunit β-1/sodium/potassium-transporting ATPase subunit α-3/sodium/potassium-transporting ATPase subunit β-2/sodium/potassium-transporting ATPase subunit α-2/sodium/potassium-transporting ATPase subunit β-3/sodium/potassium-transporting ATPase subunit γ/sodium/potassium-transporting ATPase subunit α-4 in Dog [GtoPdb: 8338378358388348392610836]
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  • Sodium/potassium-transporting ATPase alpha-1 chain in Dog [ChEMBL: CHEMBL4838] [UniProtKB: P50997]
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  • OATP4C1/Solute carrier organic anion transporter family member 4C1 in Human [ChEMBL: CHEMBL2073690] [GtoPdb: 1227] [UniProtKB: Q6ZQN7]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
sodium/potassium-transporting ATPase subunit α-1/sodium/potassium-transporting ATPase subunit β-1/sodium/potassium-transporting ATPase subunit α-3/sodium/potassium-transporting ATPase subunit β-2/sodium/potassium-transporting ATPase subunit α-2/sodium/potassium-transporting ATPase subunit β-3/sodium/potassium-transporting ATPase subunit γ/sodium/potassium-transporting ATPase subunit α-4/Sodium/potassium-transporting ATPase in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095186] [GtoPdb: 8338378358388348392610836] [UniProtKB: P05023P05026P13637P14415P50993P54709P54710Q13733]
ChEMBL Inhibition of [3H]- ouabain binding to digitalis receptor B 8.1 pIC50 8 nM IC50 J. Med. Chem. (1993) 36: 42-45 [PMID:8421289]
sodium/potassium-transporting ATPase subunit α-1/sodium/potassium-transporting ATPase subunit β-1/sodium/potassium-transporting ATPase subunit α-3/sodium/potassium-transporting ATPase subunit β-2/sodium/potassium-transporting ATPase subunit α-2/sodium/potassium-transporting ATPase subunit β-3/sodium/potassium-transporting ATPase subunit γ/sodium/potassium-transporting ATPase subunit α-4 in Dog [GtoPdb: 8338378358388348392610836]
GtoPdb - - 8.1 pIC50 8 nM IC50 J. Med. Chem. (1993) 36: 42-5 [PMID:8421289]
Sodium/potassium-transporting ATPase alpha-1 chain in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4838] [UniProtKB: P50997]
ChEMBL Inhibition of [3H]ouabain binding to Digitalis receptor in dog heart microsomes B 8.1 pIC50 8 nM IC50 J. Med. Chem. (1997) 40: 1439-1446 [PMID:9154966]
OATP4C1/Solute carrier organic anion transporter family member 4C1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073690] [GtoPdb: 1227] [UniProtKB: Q6ZQN7]
ChEMBL TP_TRANSPORTER: inhibition of Digoxin uptake in OATP4C1-expressing MDCK cells F 6.92 pIC50 120 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2004) 101: 3569-3574 [PMID:14993604]

ChEMBL data shown on this page come from version 25:

A.P. Bento, A. Gaulton, A. Hersey, et al. (2014). The ChEMBL bioactivity database: an update. Nucl. Acids Res. Database Issue. 42 D1083-D1090. [PMID:24214965]