digitoxin [Ligand Id: 6782] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL254219 (Cristapurat, Crystodigin, CRYSTODIGIN, Digimerck, Digitalin, crystalline, Digitophyllin, Digitoxin, Digitoxinum, Digitoxoside, Glucodigin, Lanatoxin, Nativelle digitaline, NSC-7529, Purpurid, Tradigal) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| sodium/potassium-transporting ATPase subunit α-1/sodium/potassium-transporting ATPase subunit β-1/sodium/potassium-transporting ATPase subunit α-3/sodium/potassium-transporting ATPase subunit β-2/sodium/potassium-transporting ATPase subunit α-2/sodium/potassium-transporting ATPase subunit β-3/sodium/potassium-transporting ATPase subunit γ/sodium/potassium-transporting ATPase subunit α-4/Sodium/potassium-transporting ATPase in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095186] [GtoPdb: 833, 837, 835, 838, 834, 839, 2610, 836] [UniProtKB: P05023, P05026, P13637, P14415, P50993, P54709, P54710, Q13733] | ||||||||
| ChEMBL | Inhibition of [3H]- ouabain binding to digitalis receptor | B | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (1993) 36: 42-45 [PMID:8421289] |
| sodium/potassium-transporting ATPase subunit α-1/sodium/potassium-transporting ATPase subunit β-1/sodium/potassium-transporting ATPase subunit α-3/sodium/potassium-transporting ATPase subunit β-2/sodium/potassium-transporting ATPase subunit α-2/sodium/potassium-transporting ATPase subunit β-3/sodium/potassium-transporting ATPase subunit γ/sodium/potassium-transporting ATPase subunit α-4 in Dog [GtoPdb: 833, 837, 835, 838, 834, 839, 2610, 836] | ||||||||
| GtoPdb | - | - | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (1993) 36: 42-5 [PMID:8421289] |
| Sodium/potassium-transporting ATPase alpha-1 chain in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4838] [UniProtKB: P50997] | ||||||||
| ChEMBL | Inhibition of [3H]ouabain binding to Digitalis receptor in dog heart microsomes | B | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (1997) 40: 1439-1446 [PMID:9154966] |
| OATP4C1/Solute carrier organic anion transporter family member 4C1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073690] [GtoPdb: 1227] [UniProtKB: Q6ZQN7] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of Digoxin uptake in OATP4C1-expressing MDCK cells | F | 6.92 | pIC50 | 120 | nM | IC50 | Proc Natl Acad Sci U S A (2004) 101: 3569-3574 [PMID:14993604] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
