practolol   Click here for help

GtoPdb Ligand ID: 555

Synonyms: AY-21011 | ICI-50172
Approved drug
practolol is an approved drug
Compound class: Synthetic organic
Comment: The approved drug practolol is mixture of two enantiomers; (R)-practolol and (S)-practolol. The structure shown here does not specify stereochemistry and represents the mixture.
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 70.59
Molecular weight 266.16
XLogP 1.02
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES OC(COc1ccc(cc1)NC(=O)C)CNC(C)C
Isomeric SMILES OC(COc1ccc(cc1)NC(=O)C)CNC(C)C
InChI InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)
No information available.
Summary of Clinical Use Click here for help
Used in the emergency treatment of cardiac arrhythmias. There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency websites. Individual national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Antagonist of beta-1 adrenoceptors in the heart and vascular smooth muscle, competing with the binding of adrenaline and noradrenaline and therefore inhibiting their effects, this has the outcome of decreasing heart rate, cardiac output and systolic and diastolic blood pressure.