ChEMBL ligand: CHEMBL6995 ([3-(4-Acetylamino-Phenoxy)-2-Hydroxy-Propyl]-Isopropyl-Ammonium, AY-21011, AY-21,011, Dalzic, Eraldin, I.C.I. 50,172, I.C.I.-50,172, ICI-50172, Practolol)
β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588] β1-adrenoceptor/Beta-1 adrenergic receptor in Rat [ChEMBL: CHEMBL3252] [GtoPdb: 28] [UniProtKB: P18090] Beta-1 adrenergic receptor in Guinea pig [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73] There should be some charts here, you may need to enable JavaScript!
Beta-2 adrenergic receptor in Dog [ChEMBL: CHEMBL2289] [UniProtKB: P54833] Beta-2 adrenergic receptor in Bovine [ChEMBL: CHEMBL3373] [UniProtKB: Q28044] β2-adrenoceptor/Beta-2 adrenergic receptor in Mouse [ChEMBL: CHEMBL3707] [GtoPdb: 29] [UniProtKB: P18762] β2-adrenoceptor/Beta-2 adrenergic receptor in Rat [ChEMBL: CHEMBL3754] [GtoPdb: 29] [UniProtKB: P10608] Beta-2 adrenergic receptor in Guinea pig [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
GtoPdb	-	-	6.8	pKi	-	-	-	Eur J Pharmacol (1999) 367: 431-5 [PMID:10079020]; Br J Pharmacol (2005) 144: 317-22 [PMID:15655528]
β1-adrenoceptor/Beta-1 adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3252] [GtoPdb: 28] [UniProtKB: P18090]
ChEMBL	Apparent dissociation constant towards beta-1 adrenergic receptor in rat heart membranes using (2-6)x10E-9M of [3AH]-DHA in the presence or absence of 10e-5 M (+/-) propranolol.	B	6.21	pKd	0	M	KD'	J. Med. Chem. (1987) 30: 722-726 [PMID:3031293]
ChEMBL	Antagonist activity at beta1 adrenergic receptor in isolated rat atria	B	6.47	pKd	338.84	nM	Kd	J. Med. Chem. (1978) 21: 982-984 [PMID:31488]
Beta-1 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73]
ChEMBL	Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea	F	5.08	pKd	8317.64	nM	Kd	J. Med. Chem. (1987) 30: 1003-1011 [PMID:2884312]
ChEMBL	Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria	F	5.78	pKd	1659.59	nM	Kd	J. Med. Chem. (1987) 30: 616-622 [PMID:2882026]
ChEMBL	Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria	F	5.78	pKd	1659.59	nM	Kd	J. Med. Chem. (1985) 28: 153-160 [PMID:2857200]
ChEMBL	Activity at beta-1 adrenergic receptor	B	6	pKd	1000	nM	Kd	J. Med. Chem. (1992) 35: 4676-4682 [PMID:1361581]
ChEMBL	Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation	B	6.6	pKd	251.19	nM	Kd	J. Med. Chem. (1982) 25: 1408-1412 [PMID:6130154]
ChEMBL	Antagonist activity at beta1 adrenoceptor in guinea pig atrium assessed as inhibition of isoproterenol-induced response after 20 mins	B	6.67	pKd	213.8	nM	Kd	J. Med. Chem. (1978) 21: 1081-1084 [PMID:31474]
ChEMBL	Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria	F	6.76	pKd	173.78	nM	Kd	J. Med. Chem. (1981) 24: 994-998 [PMID:6120237]
ChEMBL	In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea pig atrial preparations	B	6.98	pKd	104.71	nM	Kd	J. Med. Chem. (1983) 26: 950-957 [PMID:6134834]
Beta-2 adrenergic receptor in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2289] [UniProtKB: P54833]
ChEMBL	Cardioselectivity for the beta-2 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria	F	6.73	pKd	186.21	nM	Kd	J. Med. Chem. (1987) 30: 1003-1011 [PMID:2884312]
Beta-2 adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3373] [UniProtKB: Q28044]
ChEMBL	Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)	B	4.69	pKd	20417	nM	Kd	J. Med. Chem. (1985) 28: 1328-1334 [PMID:2993621]
ChEMBL	Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)	B	4.99	pKd	4.99	-	-Log KD	J. Med. Chem. (1985) 28: 1328-1334 [PMID:2993621]
β2-adrenoceptor/Beta-2 adrenergic receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3707] [GtoPdb: 29] [UniProtKB: P18762]
ChEMBL	Ki value was determined by accumulation of c-AMP in S-49 mouse lymphoma cells (Beta2).	B	4.87	pKi	13500	nM	Ki	J. Med. Chem. (1990) 33: 216-223 [PMID:1967313]
β2-adrenoceptor/Beta-2 adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3754] [GtoPdb: 29] [UniProtKB: P10608]
ChEMBL	Apparent dissociation constant towards beta-2 adrenergic receptor in rat lung membranes using (2-6)x10E-9M of [3AH]-DHA in the presence or absence of 10e-5 M (+/-) propranolol.	B	5.44	pKd	0	M	KD'	J. Med. Chem. (1987) 30: 722-726 [PMID:3031293]
Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4]
ChEMBL	Antagonistic activity against beta-2 adrenergic receptor on isolated guinea pig tracheal strips	F	4.5	pKd	31622.78	nM	Kd	J. Med. Chem. (1985) 28: 153-160 [PMID:2857200]
ChEMBL	Antagonist activity against beta-2 adrenergic receptor in isolated guinea pig trachea	F	4.5	pKd	31622.78	nM	Kd	J. Med. Chem. (1987) 30: 616-622 [PMID:2882026]
ChEMBL	Antagonist activity at beta2 adrenoceptor in guinea pig trachea assessed as inhibition of isoproterenol-induced response after 20 mins	B	5.2	pKd	6309.57	nM	Kd	J. Med. Chem. (1978) 21: 1081-1084 [PMID:31474]
ChEMBL	In vitro beta-2 adrenergic receptor activity was determined by measuring inhibition of the isoproterenol induced relaxation in isolated guinea pig tracheal chains contracted with PGF2-alpha	B	5.35	pKd	4466.84	nM	Kd	J. Med. Chem. (1983) 26: 950-957 [PMID:6134834]
ChEMBL	Ability to block Beta-2 adrenergic receptor in guinea pig trachea preparation	B	5.8	pKd	1584.89	nM	Kd	J. Med. Chem. (1982) 25: 1408-1412 [PMID:6130154]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]