IL-17A   Click here for help

GtoPdb Ligand ID: 4982

Synonyms: CTLA-8 | interleukin-17 alpha
Immunopharmacology Ligand
Comment: Forms homodimeric ligand IL-17A, or heterodimeric IL-17A/IL-17F.
Species: Human
No information available.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The IL-17A/IL-17R pathway appears to be central in the pathogenesis of psoriasis and other immune-mediated diseases, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and multiple sclerosis [12,17]. IL-17A is a proinflammatory cytokine and is the primary effector of type 17 helper T (Th17) cells [13-14]. IL-17A is also secreted by γδ T cells [5-6], neutrophils, and mast cells [11] found in psoriatic lesions. IL-17A stimulates keratinocytes to secrete chemokines and other proinflammatory mediators that recruit additional inflammatory cells, including neutrophils, Th17 cells, dendritic cells, and innate lymphoid cells [9,12].