lumiracoxib   Click here for help

GtoPdb Ligand ID: 2897

Synonyms: Prexige®
Approved drug PDB Ligand Immunopharmacology Ligand
lumiracoxib is an approved drug
Compound class: Synthetic organic
Comment: Lumiracoxib is a carboxylic acid, selective COX-2 inhibitor, non-steroidal anti-inflammatory (NSAID) drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 49.33
Molecular weight 293.06
XLogP 3.88
No. Lipinski's rules broken 0
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Canonical SMILES OC(=O)Cc1cc(C)ccc1Nc1c(F)cccc1Cl
Isomeric SMILES OC(=O)Cc1cc(C)ccc1Nc1c(F)cccc1Cl
InChI InChI=1S/C15H13ClFNO2/c1-9-5-6-13(10(7-9)8-14(19)20)18-15-11(16)3-2-4-12(15)17/h2-7,18H,8H2,1H3,(H,19,20)
No information available.
Summary of Clinical Use Click here for help
A non-steroidal anti-inflammatory drug that has been used in the treatment of osteoarthritis. Withdrawn from use in the EU, Canada, Australia, and New Zealand, lumiracoxib is still used clinically in several countries in Central and South America.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Inhibitor of COX-2, leading to the inhibition of prostaglandin synthesis.