lumiracoxib [Ligand Id: 2897] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL404108 (Lumiracoxib, Prexige, COX-189)
  • COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
  • This target only has 0 pki data point
  • 0
1 CHEMBL404108_lig_chart_1 Cyclooxygenase-1 Human
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2 CHEMBL404108_lig_chart_2 Cyclooxygenase-2 HumanMouse
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL Inhibition of COX1 B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2007) 50: 1425-1441 [PMID:17341061]
ChEMBL Inhibition of COX1 B 8.15 pIC50 7 nM IC50 J. Med. Chem. (2012) 55: 2932-2942 [PMID:22236250]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
GtoPdb - - 6.49 pKi 320 nM Ki J Biol Chem (2007) 282: 16379-90 [PMID:17434872]
ChEMBL Inhibition of human COX2 preincubated before addition of [1-14C]arachidonic acid B 6.49 pKi 320 nM Ki J. Biol. Chem. (2007) 282: 16379-16390 [PMID:17434872]
ChEMBL Inhibition of COX2 B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2012) 55: 2932-2942 [PMID:22236250]
ChEMBL Inhibition of human COX2 mediated PGE2 production in human whole blood B 6.85 pIC50 140 nM IC50 J. Biol. Chem. (2007) 282: 16379-16390 [PMID:17434872]
ChEMBL Inhibition of COX2 (unknown origin) B 6.85 pIC50 140 nM IC50 MedChemComm (2015) 6: 2081-2123
ChEMBL Inhibition of human COX2 mediated PGE2 production in IL-1-beta-induced human dermal fibroblast cells B 6.89 pIC50 130 nM IC50 J. Biol. Chem. (2007) 282: 16379-16390 [PMID:17434872]
ChEMBL Inhibition of human COX2 for 17 mins pre-incubated before addition of [1-14C]arachidonic acid B 6.97 pIC50 107 nM IC50 J. Biol. Chem. (2007) 282: 16379-16390 [PMID:17434872]
ChEMBL Inhibition of COX-2 (unknown origin) B 7.22 pIC50 60 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 1516-1520 [PMID:26898334]
ChEMBL Inhibition of COX2 B 8.15 pIC50 7 nM IC50 J. Med. Chem. (2007) 50: 1425-1441 [PMID:17341061]
COX-2 /Cyclooxygenase-2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769]
ChEMBL Inhibition of purified mouse COX-2 assessed as inhibition of PGE2-G/PGD2-G formation preincubated for 3 mins before 2-AG substrate addition measured after 30 seconds by LC-MS-MS method B 7.4 pIC50 40 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 5860-5864 [PMID:24060487]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]