LH   Click here for help

GtoPdb Ligand ID: 1159

Synonyms: luteinising hormone | luteinizing hormone
Approved drug
LH is an approved drug (FDA (2004))
Comment: The approved drug lutropin alfa (INN) is the recombinant form of human LH and is composed of two subunits (α = 92 amino acids, β = 121 amino acids).
Species: Human
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Summary of Clinical Use Click here for help
Used for female fertility treatment, fulfilling the same actions as endogenous pituitary luteinizing hormone. Normally used in combination with follicle stimulating hormone.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Binding to the LH receptor signals through the adenylate cylcase pathway leading to increased steroid hormone production and follicle maturation.