PF‐06526290   Click here for help

GtoPdb Ligand ID: 9980

Synonyms: PF06526290
Compound class: Synthetic organic
Comment: PF‐06526290 can exhibit both enhancement and inhibition of Nav channel function.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 128.02
Molecular weight 402.08
XLogP 1.85
No. Lipinski's rules broken 0
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Canonical SMILES O=C(Nc1nccs1)Nc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)C
Isomeric SMILES O=C(Nc1nccs1)Nc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)C
InChI InChI=1S/C18H18N4O3S2/c1-22(13-14-5-3-2-4-6-14)27(24,25)16-9-7-15(8-10-16)20-17(23)21-18-19-11-12-26-18/h2-12H,13H2,1H3,(H2,19,20,21,23)
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Nav1.7 Hs Gating inhibitor Inhibition 9.6 pEC50 - 1
pEC50 9.6 (EC50 2.7x10-10 M) [1]
Nav1.3 Hs Gating inhibitor Inhibition 9.0 pEC50 - 1
pEC50 9.0 (EC50 1.1x10-9 M) [1]