Synonyms: Arakoda® | etaquine | Krintafel® | WR238605
tafenoquine is an approved drug (FDA (2018))
Compound class:
Synthetic organic
Comment: Tafenoquine is an 8-aminoquinoline derivative that has potent antimalarial activity and is a synthetic analogue of primaquine.
The INN record for tafenoquine indicates that it is a racemic mixture. We show the chemical structure without stereochemistry to represent the mixture. The non-isomeric structure is also represented in the PubChem and ChEMBL entries listed in the links table below, while the two enantiomers forming the racemate are represented by PubChem CID 76969187 and PubChem CID 76969188. The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. |
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Bioactivity Comments |
The interaction table below provides data from an evaluation of the antimalarial (asexual blood stage) activity of tafenoquine, using a panel of P. falciparum strains and field isolates, with the results for strains W2 and D6 provided in the table (average IC50 for panel = 436nM). |
Whole organism assay data | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click on species/strain names for details | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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