- Guide to PHARMACOLOGY
Synonyms: compound 7 [PMID: 22172702]
Compound class: Synthetic organic
Comment: Ro3280 is a potent and selective inhibitor of Polo-like kinase 1 (PLK1) with antitumour activity in vivo (xenografts) .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Inhibits proliferation of NCI-H82 human lung small cell carcinoma cells with an EC50 of 6nM .
Binding constant data for additional kinases (part of an Ambit selectivity screen at 1μM Ro3280) are available in Table 4 of reference .
|Selectivity at enzymes|
|Key to terms and symbols||Click column headers to sort|