ChEMBL ligand: CHEMBL2392553
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] There should be some charts here, you may need to enable JavaScript!
FER tyrosine kinase in Human [GtoPdb: 2022] [UniProtKB: P16591] There should be some charts here, you may need to enable JavaScript!
TTK protein kinase in Human [GtoPdb: 2264] [UniProtKB: P33981] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
GtoPdb	Ambit selectivity screen at 1μM Ro3280.	-	10.05	pKd	0.09	nM	Kd	Bioorg Med Chem Lett (2012) 22: 1247-50 [PMID:22172702]
ChEMBL	Inhibition of PLK1 (unknown origin) using biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay	B	8.4	pIC50	4	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 3662-3666 [PMID:23664874]
GtoPdb	In a biochemical enzymatic assay.	-	8.52	pIC50	3	nM	IC50	Bioorg Med Chem Lett (2012) 22: 1247-50 [PMID:22172702]
FER tyrosine kinase in Human [GtoPdb: 2022] [UniProtKB: P16591]
GtoPdb	Ambit selectivity screen at 1μM Ro3280.	-	7.28	pKd	53	nM	Kd	Bioorg Med Chem Lett (2012) 22: 1247-50 [PMID:22172702]
TTK protein kinase in Human [GtoPdb: 2264] [UniProtKB: P33981]
GtoPdb	Ambit selectivity screen at 1μM Ro3280.	-	7.29	pKd	51	nM	Kd	Bioorg Med Chem Lett (2012) 22: 1247-50 [PMID:22172702]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]