IL-22   Click here for help

GtoPdb Ligand ID: 4988

Synonyms: cytokine Zcyto18 | interleukin-22
Immunopharmacology Ligand
Comment: IL-22 is an IL-10 superfamily type II cytokine which plays a key role during inflammatory responses.
Species: Human
Natural/Endogenous Targets
Target
Interleukin-22α1/10β heteromer
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-22α1/10β heteromer Ligand is endogenous in the given species Hs Agonist Agonist - - -
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
fezakinumab Peptide Primary target of this compound Hs Antibody Binding 10.3 pKd - 1
pKd 10.3 (Kd 5.4x10-11 M) [1]
Description: Binding in an ELISA using immobilized human IL-22
Targets where the ligand is described in the comment field
Target Comment